Browsing by Author "Ramaekers, Johannes G."

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  • Acute effects of 2C-E in humans: an observational study
    Papaseit Fontanet, Esther; Olesti Muñoz, Eulàlia, 1991-; Pérez Mañá, Clara; Torrens, Marta; Grifell Guardia, Marc; Ventura, Mireia; Pozo Mendoza, Óscar J., 1975-; de Sousa Fernandes Perna, Elizabeth B.; Ramaekers, Johannes G.; Torre Fornell, Rafael de la; Farré Albaladejo, Magí (Frontiers, 2020)
    2,5-Dimethoxy-4-ethylphenethylamine (2C-E) is psychedelic phenylethylamine, with a chemical structure similar to mescaline, used as new psychoactive substance (NPS). It inhibits norepinephrine and serotonin uptake and, ...
  • Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter
    Kuypers, Kim PC; Torre Fornell, Rafael de la; Farré, Magí; Xicota Vila, Laura, 1987-; de Sousa Fernandes Perna, Elizabeth B.; Theunissen, Eef Lien; Ramaekers, Johannes G. (Nature Publishing Group, 2018)
    MDMA exerts its main effects via the serotonergic system and the serotonin transporter. The gene coding for this transporter determines the expression rate of the transporter. Previously it was shown that healthy individuals ...
  • Inhibition of MDMA-induced increase in cortisol does not prevent acute impairment of verbal memory
    Kuypers, Kim PC; Torre Fornell, Rafael de la; Farré Albaladejo, Magí; Pujadas Bastardes, Mitona; Ramaekers, Johannes G. (Wiley, 2013)
    BACKGROUND: Ecstasy use is commonly linked with memory deficits in abstinent ecstasy users. Similar impairments are being found during ecstasy intoxication after single doses of ± 3,4 metylenedioxymethamphetamine (MDMA). ...
  • MDMA-induced dissociative state not mediated by the 5-HT2A receptor
    Puxty, Drew J.; Ramaekers, Johannes G.; Torre Fornell, Rafael de la; Farré Albaladejo, Magí; Pizarro Lozano, Mª Nieves; Pujadas, Mitona; Kuypers, Kim PC (Frontiers, 2017)
    Previous research has shown that a single dose of MDMA induce a dissociative state, by elevating feelings of depersonalization and derealization. Typically, it is assumed that action on the 5-HT2A receptor is the mechanism ...
  • MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor
    Kuypers, Kim PC; Torre Fornell, Rafael de la; Farré Albaladejo, Magí; Pizarro Lozano, Mª Nieves; Xicota Vila, Laura, 1987-; Ramaekers, Johannes G. (Springer, 2018)
    BACKGROUND: MDMA has been shown to induce feelings of sociability, a positive emotional bias and enhanced empathy. While previous research has used only visual emotional stimuli, communication entails more than that single ...
  • Mephedrone and alcohol interactions in humans
    Papaseit Fontanet, Esther; Pérez Mañá, Clara; de Sousa Fernandes Perna, Elizabeth B.; Olesti Muñoz, Eulàlia, 1991-; Mateus Rodriguez, Julian Andrés; Kuypers, Kim PC; Theunissen, Eef Lien; Fonseca Casals, Francina, 1972-; Torrens, Marta; Ramaekers, Johannes G.; Torre Fornell, Rafael de la; Farré Albaladejo, Magí (Frontiers, 2020)
    Mephedrone (4-MMC, mephedrone) is a synthetic cathinone derivative included in the class of new psychoactive substances. It is commonly used simultaneously with alcohol (ethanol). The aim of the present study was to evaluate ...
  • Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience
    Madrid-Gambin, Francisco; Gómez-Gómez, Àlex; Busquets Garcia, Arnau, 1985-; Haro, Noemí; Marco Sola, Santiago; Mason, Natasha L.; Reckweg, Johannes T.; Mallaroni, Pablo; Kloft, Lilian; van Oorsouw, Kim; Toennes, Stefan W.; Torre Fornell, Rafael de la; Ramaekers, Johannes G.; Pozo Mendoza, Óscar J., 1975- (Elsevier, 2022)
    There has been a renewed interest in the potential use of psychedelics for the treatment of psychiatric conditions. Nevertheless, little is known about the mechanism of action and molecular pathways influenced by ayahuasca ...
  • Metabolomics predicts the pharmacological profile of new psychoactive substances
    Olesti Muñoz, Eulàlia, 1991-; De Toma, Ilario; Ramaekers, Johannes G.; Brunt, Tibor M.; Carbó Banús, Marcel·lí; Fernández-Avilés, Cristina; Robledo, Patricia, 1958-; Farré Albaladejo, Magí; Dierssen, Mara; Pozo Mendoza, Óscar J., 1975-; Torre Fornell, Rafael de la (SAGE Publications, 2019)
    BACKGROUND: The unprecedented proliferation of new psychoactive substances (NPS) threatens public health and challenges drug policy. Information on NPS pharmacology and toxicity is, in most cases, unavailable or very limited ...
  • No evidence that MDMA-induced enhancement of emotional empathy is related to peripheral oxytocin levels or 5-HT1a receptor activation
    Kuypers, Kim PC; Torre Fornell, Rafael de la; Farré Albaladejo, Magí; Yubero Lahoz, Samanta, 1985-; Dziobek, Isabel; Van Den Bos, Wouter; Ramaekers, Johannes G. (Public Library of Science (PLoS), 2014)
    The present study aimed at investigating the effect of MDMA on measures of empathy and social interaction, and the roles of oxytocin and the 5-HT1A receptor in these effects. The design was placebo-controlled within-subject ...
  • Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication
    Haijen, Eline; Farré Albaladejo, Magí; Torre Fornell, Rafael de la; Pastor, Antonio; Olesti Muñoz, Eulàlia, 1991-; Pizarro Lozano, Mª Nieves; Ramaekers, Johannes G.; Kuypers, Kim PC (Springer, 2018)
    BACKGROUND: Preclinical data have suggested involvement of the endocannabinoid (eCB) system in MDMA-induced memory impairment. Clinical research has shown that blockade of the 5-HT2 receptor nulls memory impairment during ...
  • Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses
    McCulloch, Drummond E-Wen; Moos Knudsen, Gitte; Streeter Barrett, Frederick; Doss, Manoj K.; Carhart-Harris, Robin Lester; Rosas, Fernando E.; Deco, Gustavo; Kringelbach, Morten L.; Preller, Katrin H.; Ramaekers, Johannes G.; Mason, Natasha L.; Müller, Felix; MacDonald Fisher, Patrick (Elsevier, 2022)
    Clinical research into serotonergic psychedelics is expanding rapidly, showing promising efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs-fMRI) is a commonly used strategy to identify ...
  • Psychopathological symptoms associated with synthetic cannabinoid use: a comparison with natural cannabis
    Mensen, Vincent T.; Vreeker, Annabel; Nordgren, Johan; Atkinson, Amanda; Torre Fornell, Rafael de la; Farré Albaladejo, Magí; Ramaekers, Johannes G.; Brunt, Tibor M. (SpringerOpen, 2019)
    Background: Synthetic cannabinoids (SCs) are a class of new psychoactive substances that have been rapidly evolving around the world throughout recent years. Many different synthetic cannabinoid analogues are on the consumer ...
  • Quantification of endogenous neurotransmitters and related compounds by liquid chromatography coupled to tandem mass spectrometry
    Olesti Muñoz, Eulàlia, 1991-; Rodríguez-Morató, Jose, 1987-; Gomez-Gomez, Àlex; Ramaekers, Johannes G.; Torre Fornell, Rafael de la; Pozo Mendoza, Óscar J., 1975- (Elsevier, 2019)
    Neurotransmitters are signaling molecules, playing key roles in neuronal communications in the brain. Drug induced changes in neurotransmitters and other brain metabolite concentration may be used to characterize drugs ...