Browsing by Author "Rajewsky, Nicolaus"

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  • Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians
    Solana, Jordi; Irimia, Manuel; Ayoub, Salah; Rodriguez Orejuela, Marta; Zywitza, Vera; Jens, Marvin; Tapial Rodríguez, Javier, 1990-; Ray, Debashish; Morris, Quaid; Hughes, Timothy R.; Blencowe, Benjamin J.; Rajewsky, Nicolaus (eLife, 2016)
    In contrast to transcriptional regulation, the function of alternative splicing (AS) in stem cells is poorly understood. In mammals, MBNL proteins negatively regulate an exon program specific of embryonic stem cells; ...
  • LifeTime and improving European healthcare through cell-based interceptive medicine
    Rajewsky, Nicolaus; Bertero, Michela G.; Martí Renom, Marc A.; LifeTime Community (Nature Research, 2020)
    LifeTime aims to track, understand and target human cells during the onset and progression of complex diseases and their response to therapy at single-cell resolution. This mission will be implemented through the development ...
  • MicroRNAs are deeply linked to the emergence of the complex octopus brain
    Zolotarov, Grygoriy; Fromm, Bastian; Legnini, Ivano; Ayoub, Salah; Polese, Gianluca; Maselli, Valeria; Chabot, Peter J.; Vinther, Jakob; Styfhals, Ruth; Seuntjens, Eve; Di Cosmo, Anna; Peterson, Kevin J.; Rajewsky, Nicolaus (American Association for the Advancement of Science (AAAS), 2022)
    Soft-bodied cephalopods such as octopuses are exceptionally intelligent invertebrates with a highly complex nervous system that evolved independently from vertebrates. Because of elevated RNA editing in their nervous ...