Browsing by Author "Prado Martínez, Javier, 1987-"

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  • Ancient gene flow from early modern humans into Eastern Neanderthals
    Kuhlwilm, Martin; Prado Martínez, Javier, 1987-; Lalueza Fox, Carles, 1965-; Marquès i Bonet, Tomàs, 1975-; Castellano Hereza, Sergi (Nature Research, 2016)
    It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together ...
  • Characterization of nuclear mitochondrial insertions in the whole genomes of primates
    Dayama, Gargi; Zhou, Weichen; Prado Martínez, Javier, 1987-; Marquès i Bonet, Tomàs, 1975-; Mills, Ryan E. (Oxford University Press, 2020)
    The transfer and integration of whole and partial mitochondrial genomes into the nuclear genomes of eukaryotes is an ongoing process that has facilitated the transfer of genes and contributed to the evolution of various ...
  • Chimpanzee genomic diversity reveals ancient admixture with bonobos
    de Manuel, Marc; Kuhlwilm, Martin; Sousa, Victor C.; Prado Martínez, Javier, 1987-; Hernández Rodríguez, Jéssica, 1983-; Dupanloup, Isabelle; Lao Grueso, Oscar, 1976-; Heredia Genestar, José María, 1985-; Kuderna, Lukas F.K.; Casals López, Ferran; Angedakin, Samuel; Arandjelovic, Mimi; Boesch, Christophe; Kühl, Hjalmar S.; Vigilant, Linda; Navarro i Cuartiellas, Arcadi, 1969-; Excoffier, Laurent; Marquès i Bonet, Tomàs, 1975- (American Association for the Advancement of Science (AAAS), 2016)
    Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that ...
  • Demographic history of the genus Pan inferred from whole mitochondrial genome reconstructions
    Lobón, Irene; Tucci, Serena; de Manuel, Marc; Ghirotto, Silvia; Benazzo, Andrea; Prado Martínez, Javier, 1987-; Lorente-Galdós, Belén, 1981-; Nam, Kiwoong; Dabad, Marc; Hernández Rodríguez, Jéssica, 1983-; Comas, David, 1969-; Navarro i Cuartiellas, Arcadi, 1969-; Schierup, Mikkel H.; Andrés Morán, Aida, 1976-; Barbujani, Guido; Hvilsom, Christina; Marquès i Bonet, Tomàs, 1975- (Oxford University Press, 2016)
    The genus Pan is the closest genus to our own and it includes two species, Pan paniscus (bonobos) and Pan troglodytes (chimpanzees). The later is constituted by four subspecies, all highly endangered. The study of the Pan ...
  • Dynamics of DNA methylation in recent human and great ape evolution
    Hernando Herráez, Irene, 1985-; Prado Martínez, Javier, 1987-; Garg, Paras; Fernández Callejo, Marcos; Heyn, Holger; Hvilsom, Christina; Navarro i Cuartiellas, Arcadi, 1969-; Esteller, Manel; Sharp, Andrew J.; Marquès i Bonet, Tomàs, 1975- (Public Library of Science (PLoS), 2013)
    DNA methylation is an epigenetic modification involved in regulatory processes such as cell differentiation during development, X-chromosome inactivation, genomic imprinting and susceptibility to complex disease. However, ...
  • Especial Innovación tecnológica, una asignatura pendiente
    Ellacuria, J.; Mínguez, N.; Prado Martínez, Javier, 1987-; Soler, J. L. (Quark, 1999-01-14)
  • Evolution and diversity of copy number variation in the great ape lineage
    Sudmant, Peter H.; Huddleston, John; Catacchio, Claudia R.; Malig, Maika; Hillier, LeDeana W.; Baker, Carl; Mohajeri, Kiana; Kondova, Ivanela; Bontrop, Ronald E.; Persengiev, Stephan; Antonacci, Francesca; Ventura, Mario; Prado Martínez, Javier, 1987-; Marquès i Bonet, Tomàs, 1975-; Eichler, Evan E.; Project Great Ape Genome (Cold Spring Harbor Laboratory Press (CSHL Press), 2013)
    Copy number variation (CNV) contributes to disease and has restructured the genomes of great apes. The diversity and rate of this process, however, have not been extensively explored among great ape lineages. We analyzed ...
  • Gene fusions derived by transcriptional readthrough are driven by segmental duplication in human
    McCartney, Ann M.; Hyland, Edel M.; Cormican, Paul; Moran, Raymond J.; Webb, Andrew E.; Lee, Kate D.; Hernández Rodríguez, Jéssica, 1983-; Prado Martínez, Javier, 1987-; Creevey, Christopher J.; Aspden, Julie L.; McInerney, James O.; Marquès i Bonet, Tomàs, 1975-; O'Connell, Mary J. (Oxford University Press, 2019)
    Gene fusion occurs when two or more individual genes with independent open reading frames becoming juxtaposed under the same open reading frame creating a new fused gene. A small number of gene fusions described in detail ...
  • Genetic load of loss-of-function polymorphic variants in great apes
    de Valles-Ibáñez, Guillem; Hernández Rodríguez, Jéssica, 1983-; Prado Martínez, Javier, 1987-; Luisi, Pierre, 1985-; Marquès i Bonet, Tomàs, 1975-; Casals López, Ferran (Oxford University Press, 2016)
    Loss of function (LoF) genetic variants are predicted to disrupt gene function, and are therefore expected to substantially reduce individual's viability. Knowing the genetic burden of LoF variants in endangered species ...
  • Great ape genetic diversity and population history
    Prado Martínez, Javier, 1987-; Lorente-Galdós, Belén, 1981-; Santpere Baró, Gabriel, 1981-; Casals López, Ferran; Laayouni, Hafid, 1968-; Hernández Rodríguez, Jéssica, 1983-; Hernando Herráez, Irene, 1985-; Pybus Oliveras, Marc, 1985-; Petit, Natalia; Fernández Callejo, Marcos; Dabad, Marc; Carvalho, Tiago Loureiro de, 1987-; Melé Messeguer, Marta, 1982-; Comas, David, 1969-; Navarro i Cuartiellas, Arcadi, 1969-; Bertranpetit, Jaume, 1952-; Marquès i Bonet, Tomàs, 1975- (Nature Publishing Group, 2013)
    Most great ape genetic variation remains uncharacterized1, 2; however, its study is critical for understanding population history3, 4, 5, 6, recombination7, selection8 and susceptibility to disease9, 10. Here we sequence ...
  • Great ape genomics : diversity and evolution
    Prado Martínez, Javier, 1987- (Universitat Pompeu Fabra, 2015-02-27)
    Els grans simis són els nostres parents evolutius més propers i com a tals són la millor eina per entendre els nostres orígens més recents. Mitjançant la genòmica comparativa ara podem estudiar en profunditat aquesta ...
  • Labyrinthopeptins exert broad-spectrum antiviral activity through lipid-binding-mediated virolysis
    Prochnow, Hans; Prado Martínez, Javier, 1987-; Meyerhans, Andreas; Brönstrup, Mark (American Society for Microbiology, 2020)
    To counteract the serious health threat posed by known and novel viral pathogens, drugs that target a variety of viruses through a common mechanism have attracted recent attention due to their potential in treating ...
  • Morphometric, behavioral, and genomic evidence for a new orangutan species
    Nater, Alexander; Mattle-Greminger, Maja P.; Nurcahyo, Anton; Novak, Matthew G.; de Manuel, Marc; Desai, Tariq; Groves, Colin; Pybus Oliveras, Marc, 1985-; Sonay, Tugce Bilgin; Roos, Christian; Lameira, Adriano R.; Wich, Serge A.; Askew, James; Davila-Ross, Marina; Fredriksson, Gabriella; de Valles-Ibáñez, Guillem; Casals López, Ferran; Prado Martínez, Javier, 1987-; Goossens, Benoit; Verschoor, Ernst J.; Warren, Kristin S.; Singleton, Ian; Marques, David A.; Pamungkas, Joko; Perwitasari-Farajallah, Dyah; Rianti, Puji; Tuuga, Augustine; Gut, Ivo Glynne; Gut, Marta; Orozco-terWengel, Pablo; Van Schaik, Carel P.; Bertranpetit, Jaume, 1952-; Anisimova, Maria; Scally, Aylwyn; Marquès i Bonet, Tomàs, 1975-; Meijaard, Erik; Krützen, Michael (Elsevier, 2017)
    Six extant species of non-human great apes are currently recognized: Sumatran and Bornean orangutans, eastern and western gorillas, and chimpanzees and bonobos [1]. However, large gaps remain in our knowledge of fine-scale ...
  • Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding
    Xue, Yali; Prado Martínez, Javier, 1987-; de Manuel, Marc; Hernández Rodríguez, Jéssica, 1983-; Lobón, Irene; Marquès i Bonet, Tomàs, 1975-; Scally, Aylwyn (American Association for the Advancement of Science (AAAS), 2015)
    Mountain gorillas are an endangered great ape subspecies and a prominent focus for conservation, yet we know little about their genomic diversity and evolutionary past. We sequenced whole genomes from multiple wild individuals ...
  • The genome sequencing of an albino Western lowland gorilla reveals inbreeding in the wild
    Prado Martínez, Javier, 1987-; Hernando Herráez, Irene, 1985-; Lorente-Galdós, Belén, 1981-; Dabad, Marc; Ramírez, Oscar; Baeza Delgado, Carlos; Morcillo Suárez, Carlos, 1969-; Alkan, Can; Hormozdiari, Fereydoun; Raineri, Emanuele; Estellé, Jordi; Fernández Callejo, Marcos; Vallès, Mònica; Ritscher, Lars; Schöneberg, Torsten; Calle Mustienes, Elisa de la; Casillas, Sònia; Rubio Acero, Raquel; Melé Messeguer, Marta, 1982-; Engelken, Johannes; Cáceres Aguilar, Mario; Gómez Skarmeta, José Luis; Gut, Marta; Bertranpetit, Jaume, 1952-; Gut, Ivo Glynne; Abelló, Teresa; Eichler, Evan E.; Mingarro, Ismael; Lalueza Fox, Carles, 1965-; Navarro i Cuartiellas, Arcadi, 1969-; Marquès i Bonet, Tomàs, 1975- (BioMed Central, 2013)
    BACKGROUND: The only known albino gorilla, named Snowflake, was a male wild born individual from Equatorial Guinea who lived at the Barcelona Zoo for almost 40 years. He was diagnosed with non-syndromic oculocutaneous ...
  • The interplay between DNA methylation and sequence divergence in recent human evolution
    Hernando Herráez, Irene, 1985-; Heyn, Holger; Fernández Callejo, Marcos; Vidal, Enrique; Fernández Bellon, Hugo; Prado Martínez, Javier, 1987-; Sharp, Andrew J.; Esteller, Manel; Marquès i Bonet, Tomàs, 1975- (Oxford University Press, 2015)
    Despite the increasing knowledge about DNA methylation, the understanding of human epigenome evolution is in its infancy. Using whole genome bisulfite sequencing we identified hundreds of differentially methylated regions ...