Browsing by Author "Pons Espinal, Meritxell, 1986-"

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  • Environmental enrichment induces epigenomic and genome organization changes relevant for cognition
    Espeso Gil, Sergio, 1985-; Holik, Aliaksei Z.; Bonnin, Sarah; Jhanwar, Shalu, 1986-; Chandrasekaran, Sandhya; Pique Regi, Roger; Albaigès-Ràfols, Júlia; Maher, Michael; Permanyer, Jon; Irimia, Manuel; Friedländer, Marc R.; Pons Espinal, Meritxell, 1986-; Akbarian, Schahram; Dierssen, Mara; Maass, Philipp G.; Hor, Charlotte N.; Ossowski, Stephan (Frontiers, 2021)
    In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the ...
  • Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns
    Sánchez Mut, Jose V.; Heyn, Holger; Vidal, Enrique; Moran, Sebastian; Sayols, Sergi; Delgado Morales, Raul; Schultz, Matthew D.; Ansoleaga, Belén; García Esparcia, Paula; Pons Espinal, Meritxell, 1986-; Martínez de Lagran, Maía; Dopazo, Jose M.; Rábano, Alberto; Ávila, Jesús; Dierssen, Mara; Lott, Ira T.; Ferrer, Isidre; Ecker, Joseph R.; Esteller, Manel (Nature Publishing Group, 2016)
    Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared ...
  • Parkinson's disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration
    Carola, Giulia; Malagarriga, Daniel; Calatayud, Carles; Pons Espinal, Meritxell, 1986-; Blasco Agell, Lucas; Richaud Patin, Yvonne; Fernández Carasa, Irene; Baruffi, Valentina; Beltramone, Santiago; Molina, Emilio; Dell'Era, Patrizia; Toledo Aral, Juan J.; Tolosa, Eduard; Muotri, Alysson R.; García Ojalvo, Jordi; Soriano Fradera, Jordi; Raya Chamorro, Ángel; Consiglio, Antonella (Nature Research, 2021)
    A deeper understanding of early disease mechanisms occurring in Parkinson's disease (PD) is needed to reveal restorative targets. Here we report that human induced pluripotent stem cell (iPSC)-derived dopaminergic neurons ...
  • Patient-specific iPSC-derived astrocytes contribute to non-cell-autonomous neurodegeneration in Parkinson's disease
    di Domenico, Angelique; Carola, Giulia; Calatayud, Carles; Pons Espinal, Meritxell, 1986-; Muñoz, Juan Pablo; Richaud Patin, Yvonne; Fernández Carasa, Irene; Gut, Marta; Faella, Armida; Parameswaran, Janani, 1990-; Soriano, Jordi; Ferrer, Isidre; Tolosa, Eduard; Zorzano, Antonio; Cuervo, Ana Maria; Raya Chamorro, Ángel; Consiglio, Antonella (Elsevier, 2019)
    Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell-autonomous contribution, in particular of astrocytes, ...
  • Role of DYRK1A in hippocampal neuroplasticity : implications for Down syndrome
    Pons Espinal, Meritxell, 1986- (Universitat Pompeu Fabra, 2013-10-18)
    Synaptic connections in the brain respond throughout their lives to the activity of incoming neurons, adjusting their biological properties to increment activity-dependent changes. Hippocampal neuronal plasticity disruptions ...