Browsing by Author "Plass Pórtulas, Mireya, 1982-"

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  • Comparative analysis of splicing in eukaryotes
    Plass Pórtulas, Mireya, 1982- (Universitat Pompeu Fabra, 2011-07-12)
    L’splicing és el mecanisme pel qual els introns són eliminats del pre-mRNA per generar un trànscrit madur. Aquest procés és dut a terme per un complex macromolecular anomenat spliceosoma i requereix el reconeixement dels ...
  • Deciphering 3'ss selection in the yeast genome reveals an RNA thermosensor that mediates alternative splicing
    Meyer, Markus; Plass Pórtulas, Mireya, 1982-; Pérez Valle, Jorge; Eyras Jiménez, Eduardo; Vilardell, Josep (Elsevier, 2011)
    Poor understanding of the spliceosomal mechanisms to select intronic 3' ends (3'ss) is a major obstacle to deciphering eukaryotic genomes. Here, we discern the rules for global 3'ss selection in yeast. We show that, in ...
  • DGCR8 HITS-CLIP reveals novel functions for the Microprocessor
    Macias, Sara; Plass Pórtulas, Mireya, 1982-; Stajuda, Agata; Michlewski, Gracjan; Eyras Jiménez, Eduardo; Cáceres, Javier F. (Nature Research, 2012)
    The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as the endonuclease. Using high-throughput sequencing and cross-linking ...
  • Differentiated evolutionary rates in alternative exons and the implications for splicing regulation
    Plass Pórtulas, Mireya, 1982-; Eyras Jiménez, Eduardo (BioMed Central, 2006)
    Background: Alternatively spliced exons play an important role in the diversification of gene function in most metazoans and are highly regulated by conserved motifs in exons and introns. Two contradicting properties have ...
  • Drosha regulates gene expression independently of RNA cleavage function
    Gromak, Natalia; Dienstbier, Martin; Macias, Sara; Plass Pórtulas, Mireya, 1982-; Eyras Jiménez, Eduardo; Cáceres, Javier F.; Proudfoot, Nicholas J. (Elsevier, 2013)
    Drosha is the main RNase III-like enzyme involved in the process of microRNA (miRNA) biogenesis in the nucleus. Using whole-genome ChIP-on-chip analysis, we demonstrate that, in addition to miRNA sequences, Drosha specifically ...
  • RNA secondary structure mediates alternative 3'ss selection in Saccharomyces cerevisiae
    Plass Pórtulas, Mireya, 1982-; Codony Servat, Carles; Ferreira, Pedro G.; Vilardell, Josep; Eyras Jiménez, Eduardo (Cold Spring Harbor Laboratory Press (CSHL Press) -- RNA, 2012)
    Alternative splicing is the mechanism by which different combinations of exons in the pre-mRNA give rise to distinct mature mRNAs. This process is mediated by splicing factors that bind the pre-mRNA and affect the recognition ...
  • The Microprocessor controls the activity of mammalian retrotransposons
    Heras, Sara R.; Macias, Sara; Plass Pórtulas, Mireya, 1982-; Fernandez, Noemí; Cano Ferrer, David; Eyras Jiménez, Eduardo; Garcia Perez, José L.; Cáceres, Javier F. (Nature Research, 2013)
    More than half of the human genome is made of transposable elements whose ongoing mobilization is a driving force in genetic diversity; however, little is known about how the host regulates their activity. Here, we show ...
  • The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians
    Spruce, Thomas; Plass Pórtulas, Mireya, 1982-; Gohr, André; Ray, Debashish; Martínez de Lagrán Cabredo, María; Rot, Gregor; Nóvoa, Ana; Burguera, Demián; Permanyer, Jon; Miret-Cuesta, Marta; Zheng, Hong; Swanson, Maurice S.; Morris, Quaid; Mallo, Moises; Dierssen, Mara; Hughes, Timothy R.; Pernaute, Barbara; Irimia, Manuel (Public Library of Science (PLoS), 2022)
    Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that Mbnl3 has undergone a striking process ...