Carter, Jason A.; Strömich, Léonie; Peacey, Matthew; Chapin, Sarah R.; Velten, Lars; Steinmetz, Lars M.; Brors, Benedikt; Pinto, Sheena; Meyer, Hannah V.
(Nature Research, 2022)
The induction of central T cell tolerance in the thymus depends on the presentation of peripheral self-epitopes by medullary thymic epithelial cells (mTECs). This promiscuous gene expression (pGE) drives mTEC transcriptomic ...