Browsing by Author "Pineda, Silvia"

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  • Genetic variation in the TP53 pathway and bladder cancer risk: a comprehensive analysis
    Pineda, Silvia; Milne, Roger L.; Calle, M. Luz; Rothman, Nathaniel; López De Maturana, Evangelina; Herranz, Jesús; Kogevinas, Manolis; Chanock, Stephen J.; Tardón, Adonina; Márquez, Mirari; Guey, Lin T.; García Closas, Montserrat; Lloreta Trull, Josep, 1958-; Baum, Erin; González Neira, Anna; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Silverman, Debra T.; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2014)
    Introduction: Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer genetic susceptibility. However, variants in other ...
  • Immunohistochemistry-based taxonomical classification of bladder cancer predicts response to neoadjuvant chemotherapy
    Font, Albert; Doménech, Montserrat; Benítez, Raquel; Rava, Marta; Marqués, Miriam; Ramírez, José L.; Pineda, Silvia; Domínguez Rodríguez, Miriam; Gago, José L.; Badal, Josep; Carrato, Cristina; López, Héctor; Quer, Ariadna; Castellano, Daniel; Malats i Riera, Núria; Real, Francisco X. (MDPI, 2020)
    Background: Platinum-based neoadjuvant chemotherapy (NAC) increases the survival of patients with organ-confined urothelial bladder cancer (UBC). In retrospective studies, patients with basal/squamous (BASQ)-like tumors ...
  • Integration Analysis of Three Omics Data Using Penalized Regression Methods: An Application to Bladder Cancer.
    Pineda, Silvia; Real, Francisco X.; Kogevinas, Manolis; Carrato, Alfredo; Chanock, Stephen J.; Malats i Riera, Núria; Van Steen, Kristel (Public Library of Science, 2015)
    Omics data integration is becoming necessary to investigate the genomic mechanisms involved in complex diseases. During the integration process, many challenges arise such as data heterogeneity, the smaller number of ...