Browsing by Author "Pineda, Estela"

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  • A comparison of RNA-Seq results from paired formalin-fixed paraffin-embedded and fresh-frozen glioblastoma tissue samples
    Esteve-Codina, Anna; Arpí Llucià, Oriol; Martínez-García, Maria; Pineda, Estela; Mallo, Mar; Gut, Marta; Carrato, Cristina; Rovira Guerín, Ana; Lopez, Raquel; Tortosa, Avelina; Dabad, Marc; del Barco, Sonia; Heath, Simon; Bagué, Silvia; Ribalta, Teresa; Alameda Quitllet, Francisco; de la Iglesia, Nuria; Balaña, Carmen; GLIOCAT Group (Public Library of Science (PLoS), 2017)
    The molecular classification of glioblastoma (GBM) based on gene expression might better explain outcome and response to treatment than clinical factors. Whole transcriptome sequencing using next-generation sequencing ...
  • In silico validation of RNA-Seq results can identify gene fusions with oncogenic potential in glioblastoma
    Hernandez, Ainhoa; Muñoz-Mármol, Ana M.; Esteve-Codina, Anna; Alameda Quitllet, Francisco; Carrato, Cristina; Pineda, Estela; Arpí Llucià, Oriol; Martinez-García, Maria; Mallo, Mar; Gut, Marta; Barco Berrón, Sonia del; Gallego, Oscar; Dabad, Marc; Mesia, Carlos; Bellosillo Paricio, Beatriz; Domenech, Marta; Vidal, Noemí; Aldecoa, Iban; Iglesia, Nuria de la; Balana, Carmen (Nature Research, 2022)
    RNA-Sequencing (RNA-Seq) can identify gene fusions in tumors, but not all these fusions have functional consequences. Using multiple data bases, we have performed an in silico analysis of fusions detected by RNA-Seq in ...
  • Preclinical studies with glioblastoma brain organoid co-cultures show efficient 5-ALA photodynamic therapy
    Pedrosa, Leire; Bedia, Carmen; Diao, Diouldé; Mosteiro, Alejandra; Ferrés, Abel; Stanzani, Elisabetta; Martínez-Soler, Fina; Tortosa, Avelina; Pineda, Estela; Aldecoa, Iban; Centellas, Marc; Muñoz-Tudurí, Marta; Sevilla, Ana; Sierra, Àngels; González Sánchez, José Juan (MDPI, 2023)
    Background: The high recurrence of glioblastoma (GB) that occurs adjacent to the resection cavity within two years of diagnosis urges an improvement of therapies oriented to GB local control. Photodynamic therapy (PDT) has ...
  • Safety and efficacy of crizotinib in combination with temozolomide and radiotherapy in patients with newly diagnosed glioblastoma: phase Ib GEINO 1402 trial
    Martínez-García, Maria; Velasco, Guillermo; Pineda, Estela; Gil-Gil, Miguel J.; Alameda Quitllet, Francisco; Capellades Font, Jaume; Martín-Soberón, Mari Cruz; López-Valero, Israel; Tovar Ambel, Elena; Foro Arnalot, Palmira; Taus García, Álvaro; Arumí Uría, Montserrat; Hernández-Laín, Aurelio; Sepúlveda-Sánchez, Juan Manuel (MDPI, 2022)
    Background: MET-signaling and midkine (ALK ligand) promote glioma cell maintenance and resistance against anticancer therapies. ALK and c-MET inhibition with crizotinib have a preclinical therapeutic rationale to be tested ...
  • Texture analysis of the apparent diffusion coefficient focused on contrast-enhancing Lesions in predicting survival for Bevacizumab-Treated patients with recurrent glioblastoma
    López-Rueda, Antonio; Puig, Josep; Thió-Henestrosa, Santiago; Moreno-Negrete, Javier Luis; Zwanzger, Christian; Pujol, Teresa; Aldecoa, Iban; Pineda, Estela; Valduvieco, Izaskun; González, José Juan; Oleaga, Laura (MDPI, 2023)
    Purpose: Glioblastoma often recurs after treatment. Bevacizumab increases progression-free survival in some patients with recurrent glioblastoma. Identifying pretreatment predictors of survival can help clinical decision ...
  • The C250T mutation of TERTp might grant a better prognosis to glioblastoma by exerting less biological effect on telomeres and chromosomes than the C228T mutation
    Gorria, Teresa; Crous-Bou, Marta; Pineda, Estela; Hernandez, Ainhoa; Domenech, Marta; Sanz, Carolina; Jares, Pedro; Muñoz Mármol, Ana María; Arpí Llucià, Oriol; Meléndez, Bárbara; Gut, Marta; Esteve, Anna; Esteve-Codina, Anna; Parra Farré, Genís; Alameda Quitllet, Francisco; Carrato, Cristina; Aldecoa, Iban; Mallo, Mar; Iglesia, Nuria de la; Balana, Carmen (MDPI, 2024)
    The aim of this study was to determine how TERTp mutations impact glioblastoma prognosis. Materials and methods: TERTp mutations were assessed in a retrospective cohort of 258 uniformly treated glioblastoma patients. ...

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