Browsing by Author "Picón-Pagès, Pol"

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  • A genome-wide functional screen identifies enhancer and protective genes for amyloid beta-peptide toxicity
    Picón-Pagès, Pol; Bosch Morató, Mònica, 1986-; Subirana, Laia; Rubio-Moscardó, Francisca; Guivernau Almazán, Biuse, 1988-; Fanlo-Ucar, Hugo; Zeylan, Melisa Ece; Senyuz, Simge; Herrera-Fernández, Víctor; Vicente García, Rubén, 1978-; Fernández-Fernández, José Manuel, 1967-; García Ojalvo, Jordi; Gursoy, Attila; Keskin, Ozlem; Oliva Miguel, Baldomero; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Muñoz López, Francisco José, 1964- (MDPI, 2023)
    Alzheimer's disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent AD. To identify novel molecular players in Aβ toxicity, we carried ...
  • Amyloid beta-peptide increases BACE1 translation through the phosphorylation of the eukaryotic initiation factor-2 α
    Picón-Pagès, Pol; Gutiérrez, Daniela A.; Barranco Almohalla, Alejandro; Crepin, Giulia; Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Guix Ràfols, Francesc Xavier; Menéndez, Silvia; Arumí Uría, Montserrat; Vicente García, Rubén, 1978-; Álvarez, Alejandra R.; Muñoz López, Francisco José, 1964- (Hindawi, 2020)
    Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity ...
  • Amyloid β-peptide causes the permanent activation of CaMKIIα through its oxidation
    Picón-Pagès, Pol; Fanlo-Ucar, Hugo; Herrera-Fernández, Víctor; Ausellé Bosch, Sira; Galera López, Lorena, 1993-; Gutiérrez, Daniela A.; Ozaita Mintegui, Andrés, 1969-; Álvarez, Alejandra R.; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (MDPI, 2022)
    Alzheimer's disease (AD) is characterised by the presence of extracellular amyloid plaques in the brain. They are composed of aggregated amyloid beta-peptide (Aβ) misfolded into beta-sheets which are the cause of the AD ...
  • Differential regulation of insulin signalling by monomeric and oligomeric amyloid beta-peptide
    Molina Fernández, Rubén; Picón-Pagès, Pol; Barranco Almohalla, Alejandro; Crepin, Giulia; Herrera-Fernández, Víctor; García-Elías, Anna; Fanlo-Ucar, Hugo; Fernàndez Busquets, Xavier; García Ojalvo, Jordi; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Oxford University Press, 2022)
    Alzheimer's disease and Type 2 diabetes are pathological processes associated to ageing. Moreover, there are evidences supporting a mechanistic link between Alzheimer's disease and insulin resistance (one of the first ...
  • Functions and dysfunctions of nitric oxide in brain
    Picón-Pagès, Pol; Garcia Buendia, Joan; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood flow and also has important roles in intracellular signaling in neurons from the regulation of the neuronal metabolic status to ...
  • Human albumin impairs amyloid β-peptide fibrillation through its C-terminus: from docking modeling to protection against neurotoxicity in alzheimer's disease
    Picón-Pagès, Pol; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Garcia-Buendia, Joan; Gutierrez, Daniela; Valle, Javier; Gómez-Casuso, Carmen E.S.; Sidelkivska, Valeriya; Alvarez, Alejandra; Perálvarez Marín, Alex; Suades, Albert; Fernàndez Busquets, Xavier; Andreu Martínez, David; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate ...
  • Mitostasis, calcium and free radicals in health, aging and neurodegeneration
    Godoy Zeballos, Juan Alejandro, 1959-; Rios, Juvenal A.; Picón-Pagès, Pol; Herrera-Fernández, Víctor; Swaby, Bronte; Crepin, Giulia; Vicente García, Rubén, 1978-; Fernández-Fernández, José Manuel, 1967-; Muñoz López, Francisco José, 1964- (MDPI, 2021)
    Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic plasticity. Their functional integrity is ...
  • Nigella and milk thistle seed oils: potential cytoprotective effects against 7β-hydroxycholesterol-induced toxicity on SH-SY5Y cells
    Hammouda, Souha; Ghzaiel, Imen; Picón-Pagès, Pol; Meddeb, Wiem; Khamlaoui, Wided; Hammami, Sonia; Muñoz López, Francisco José, 1964-; Hammami, Mohamed; Zarrouk, Amira (MDPI, 2021)
    Oxysterols are assumed to be the driving force behind numerous neurodegenerative diseases. In this work, we aimed to study the ability of 7β-hydroxycholesterol (7β-OHC) to trigger oxidative stress and cell death in human ...