Browsing by Author "Piñero González, Janet, 1977-"

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  • Gall, Louis; Jardí Pujol, Ferran; Lammens, Lieve; Piñero González, Janet, 1977-; Souza, Terezinha; Rodrigues, Daniela; Jennen, Danyel; de Kok, Theo M.; Coyle, Luke; Chung, Seung-Wook; Ferreira, Sofia; Jo, Heeseung; Beattie, Kylie A.; Kelly, Colette; Duckworth, Carrie A.; Pritchard, Mark; Pin, Carmen (Wiley, 2023)
    We have built a quantitative systems toxicology modeling framework focused on the early prediction of oncotherapeutic-induced clinical intestinal adverse effects. The model describes stem and progenitor cell dynamics in ...
  • Gomez-Rubio, P.; Piñero González, Janet, 1977-; Ilzarbe Sánchez, Lucas; Iglesias Coma, Mar; Poves Prim, José Ignacio; Real, Francisco X.; PanGenEU Study Investigators (Oxford University Press, 2017)
    BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed in late adulthood; therefore, many patients suffer or have suffered from other diseases. Identifying disease patterns associated with PDAC risk may ...
  • Aguirre Plans, Joaquim, 1993-; Piñero González, Janet, 1977-; Souza, Terezinha; Callegaro, Giulia; Kunnen, Steven J.; Sanz, Ferran; Fernández Fuentes, Narcís; Furlong, Laura I., 1971-; Guney, Emre; Oliva Miguel, Baldomero (BioMed Central, 2021)
    Background: Drug-induced liver injury (DILI) is an adverse reaction caused by the intake of drugs of common use that produces liver damage. The impact of DILI is estimated to affect around 20 in 100,000 inhabitants worldwide ...
  • Bauer-Mehren, Anna; van Mulligen, Erik M.; Avillach, Paul; Carrascosa Baena, María Carmen, 1972-; García Serna, Ricard; Piñero González, Janet, 1977-; Singh, Barat; Lopes, Pedro; Oliveira, José Luis; Diallo, Gayo; Ahlberg Helgee, Ernst; Boyer, Scott; Mestres i López, Jordi; Sanz, Ferran; Kors, Jan A.; Furlong, Laura I., 1971- (Public Library of Science (PLoS), 2012)
    Drug safety issues pose serious health threats to the population and constitute a major cause of mortality worldwide. Due to the prominent implications to both public health and the pharmaceutical industry, it is of great ...
  • Pérez-Granado, Judith; Piñero González, Janet, 1977-; Furlong, Laura I., 1971- (Frontiers, 2022)
    Our knowledge of complex disorders has increased in the last years thanks to the identification of genetic variants (GVs) significantly associated with disease phenotypes by genome-wide association studies (GWAS). However, ...
  • Del Toro, N.; Piñero González, Janet, 1977-; Furlong, Laura I., 1971-; Porras, P.; IMEx Consortium Curators (Nature Research, 2019)
    The current wealth of genomic variation data identified at nucleotide level presents the challenge of understanding by which mechanisms amino acid variation affects cellular processes. These effects may manifest as distinct ...
  • Martín Sánchez, Ana; Piñero González, Janet, 1977-; Nonell Mazelón, Lara; Arnal, Magdalena; Ribe, Elena; Nevado-Holgado, Alejo J.; Lovestone, Simon; Sanz, Ferran; Furlong, Laura I., 1971-; Valverde, Olga (BioMed Central, 2021)
    Background: Major depression (MD) is the most prevalent psychiatric disease in the population and is considered a prodromal stage of the Alzheimer's disease (AD). Despite both diseases having a robust genetic component, ...
  • Queralt Rosinach, Núria; Piñero González, Janet, 1977-; Bravo Serrano, Àlex, 1984-; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press , 2016)
    MOTIVATION: DisGeNET-RDF makes available knowledge on the genetic basis of human diseases in the Semantic Web. Gene-disease associations (GDAs) and their provenance metadata are published as human-readable and machine-processable ...
  • Piñero González, Janet, 1977-; Bravo Serrano, Àlex, 1984-; Queralt Rosinach, Núria; Gutiérrez Sacristán, Alba; Déu Pons, Jordi; Centeno, Emilio; García-García, Javier, 1982-; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press, 2017)
    The information about the genetic basis of human diseases lies at the heart of precision medicine and drug discovery. However, to realize its full potential to support these goals, several problems, such as fragmentation, ...
  • Piñero González, Janet, 1977-; Queralt Rosinach, Núria; Bravo Serrano, Àlex, 1984-; Déu Pons, Jordi; Bauer-Mehren, Anna; Baron, Martin; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press, 2015)
    DisGeNET is a comprehensive discovery platform designed to address a variety of questions concerning the genetic underpinning of human diseases. DisGeNET contains over 380,000 associations between >16,000 genes and 13,000 ...
  • Souza, Terezinha; Panuwat, Trairatphisan; Piñero González, Janet, 1977-; Furlong, Laura I., 1971-; Saez-Rodriguez, Julio; Kleinjans, Jos C.; Jennen, Danyel (Frontiers, 2018)
    In toxicogenomics, functional annotation is an important step to gain additional insights into genes with aberrant expression that drive pathophysiological mechanisms. Nevertheless, there exists a gap on annotation of these ...
  • Bravo Serrano, Àlex, 1984-; Piñero González, Janet, 1977-; Queralt Rosinach, Núria; Rautschka, Michael; Furlong, Laura I., 1971- (BioMed Central, 2015)
    BACKGROUND: Current biomedical research needs to leverage and exploit the large amount of information reported in scientific publications. Automated text mining approaches, in particular those aimed at finding relationships ...
  • Pérez-Granado, Judith; Piñero González, Janet, 1977-; Medina-Rivera, Alejandra; Furlong, Laura I., 1971- (MDPI, 2022)
    Understanding the molecular basis of major depression is critical for identifying new potential biomarkers and drug targets to alleviate its burden on society. Leveraging available GWAS data and functional genomic tools ...
  • Rubio Pérez, Carlota, 1990-; Güney, Emre, 1983-; Aguilar, Daniel; Piñero González, Janet, 1977-; García-García, Javier, 1982-; Iadarola, Barbara; Sanz, Ferran; Fernández Fuentes, Narcís; Furlong, Laura I., 1971-; Oliva Miguel, Baldomero (Nature Publishing Group, 2017)
    Understanding relationships between diseases, such as comorbidities, has important socio-economic implications, ranging from clinical study design to health care planning. Most studies characterize disease comorbidity using ...
  • Piñero González, Janet, 1977-; Rodriguez Fraga, Pablo S.; Valls-Margarit, Jordi; Ronzano, Francesco; Accuosto, Pablo; Lambea Jane, Ricard; Sanz, Ferran; Furlong, Laura I., 1971- (Elsevier, 2023)
    The use of molecular biomarkers to support disease diagnosis, monitor its progression, and guide drug treatment has gained traction in the last decades. While only a dozen biomarkers have been approved for their exploitation ...
  • Aguirre Plans, Joaquim, 1993-; Piñero González, Janet, 1977-; Sanz, Ferran; Furlong, Laura I., 1971-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero; Guney, Emre (Elsevier, 2019)
    The genetic basis of complex diseases involves alterations on multiple genes. Unraveling the interplay between these genetic factors is key to the discovery of new biomarkers and treatments. In 2014, we introduced GUILDify, ...
  • Callegaro, Giulia; Schimming, Johannes P.; Piñero González, Janet, 1977-; Kunnen, Steven J.; Wijaya, Lukas; Trairatphisan, Panuwat; van den Berk, Linda; Beetsma, Kim; Furlong, Laura I.; Sutherland, Jeffrey J.; Mollon, Jennifer; Stevens, James L.; van de Water, Bob (Elsevier, 2023)
    Animal testing is the current standard for drug and chemicals safety assessment, but hazards translation to human is uncertain. Human in vitro models can address the species translation but might not replicate in vivo ...
  • Piñero González, Janet, 1977-; Furlong, Laura I., 1971-; Sanz, Ferran (Elsevier, 2018)
    The use and utility of computational models in drug development has significantly grown in the last decades, fostered by the availability of high throughput datasets and new data analysis strategies. These in silico ...
  • Berenstein, Ariel José; Piñero González, Janet, 1977-; Furlong, Laura I., 1971-; Chernomoretz, Ariel (Public Library of Science, 2015)
    BACKGROUND: Cluster-based descriptions of biological networks have received much attention in recent years fostered by accumulated evidence of the existence of meaningful correlations between topological network clusters ...
  • Grosdidier, Solène; Ferrer, Antoni-Lluc, 1942-; Faner, Rosa; Piñero González, Janet, 1977-; Roca, Josep; García Cosio, Borja; Agustí, Alvar; Gea Guiral, Joaquim; Sanz, Ferran; Furlong, Laura I., 1971- (BioMed Central, 2014)
    Background: Patients with chronic obstructive pulmonary disease (COPD) often suffer concomitant disorders that worsen significantly their health status and vital prognosis. The pathogenic mechanisms underlying COPD ...

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