Browsing by Author "Perdiguero, Eusebio, 1968-"

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  • 3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice
    Guerrero, Ana; Innes, Andrew J.; Roux, Pierre-François; Buisman, Sonja C.; Jung, Johannes; Ortet Cortada, Laura; Moiseeva, Victoria, 1992-; Wagner, Verena; Robinson, Lucas; Ausema, Albertina; Potapova, Anna; Perdiguero, Eusebio, 1968-; Weersing, Ellen; Aarts, Marieke; Martin, Nadine; Wuestefeld, Torsten; Muñoz Cánoves, Pura, 1962-; Haan, Gerald de; Bischof, Oliver; Gil, Jesús (Nature Research, 2022)
    Cellular senescence is a stable type of cell cycle arrest triggered by different stresses. As such, senescence drives age-related diseases and curbs cellular replicative potential. Here, we show that 3-deazaadenosine (3DA), ...
  • Aberrant repair and fibrosis development in skeletal muscle
    Mann, Christopher J.; Perdiguero, Eusebio, 1968-; Kharraz, Yacine; Aguilar, Susana; Pessina, Patrizia; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2011)
    The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells and resident stem ...
  • Aged stem cells reprogram their daily rhythmic functions to adapt to stress
    Solanas, Guiomar; Oliveira Peixoto, Francisca; Perdiguero, Eusebio, 1968-; Jardí, Mercè; Ruiz Bonilla, Vanesa, 1979-; Datta, Debayan; Symeonidi, Aikaterini; Castellanos, Andrés; Welz, Patrick-Simon; Martín Caballero, Juan; Sassone-Corsi, Paolo; Muñoz Cánoves, Pura, 1962-; Aznar Benitah, Salvador (Elsevier, 2017)
    Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain behaviorally circadian and that their ...
  • Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscles
    Sreenivasan, Krishnamoorthy; Ianni, Alessandro; Künne, Carsten; Strilic, Boris; Günther, Stefan; Perdiguero, Eusebio, 1968-; Krüger, Marcus; Spuler, Simone; Offermanns, Stefan; Gómez del Arco, Pablo; Redondo, Juan Miguel; Muñoz Cánoves, Pura, 1962-; Kim, Johnny; Braun, Thomas (Elsevier, 2020)
    Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore ...
  • Cellular senescence in skeletal muscle regeneration, ageing and disease
    Moiseeva, Victoria, 1992- (Universitat Pompeu Fabra, 2022-07-25)
    Este proyecto se centra en el papel de las células senescentes durante la regeneración muscular desde varios ángulos. Para llevarlo a cabo, hemos desarrollado una técnica novedosa para poder aislar células senescentes ...
  • CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration
    Sreenivasan, Krishnamoorthy; Rodríguez de la Rosa, Alejandra; Kim, Johnny; Mesquita, Diana; Segalés Dalmau, Jessica; Gómez del Arco, Pablo; Espejo, Isabel; Ianni, Alessandro; Di Croce, Luciano; Relaix, Frederic; Redondo, Juan Miguel; Braun, Thomas; Serrano Sánchez, Antonio L.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Elsevier, 2021)
    Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is ...
  • Chromatin-wide and transcriptome profiling integration uncovers p38α MAPK as a global regulator of skeletal muscle differentiation
    Segalés Dalmau, Jessica; Islam, Abul, 1978-; Kumar, Roshan; Liu, Qi-Cai; Sousa-Victor, Pedro; Dilworth, F. Jeffrey; Ballestar, Esteban; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2016)
    Background: Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although ...
  • Cilia control fat deposition during tissue repair
    Perdiguero, Eusebio, 1968-; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Elsevier, 2017)
    Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the ...
  • Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle
    Iavarone, Francescopaolo; Guardiola, Ombretta; Scagliola, Alessandra; Andolfi, Gennaro; Esposito, Federica; Serrano Sánchez, Antonio L.; Perdiguero, Eusebio, 1968-; Brunelli, Silvia; Muñoz Cánoves, Pura, 1962-; Minchiotti, Gabriella (EMBO Press, 2020)
    Macrophages are characterized by a high plasticity in response to changes in tissue microenvironment, which allows them to acquire different phenotypes and to exert essential functions in complex processes, such as tissue ...
  • Fibrogenic cell plasticity blunts tissue regeneration and aggravates muscular dystrophy
    Pessina, Patrizia; Kharraz, Yacine; Jardí, Mercè; Fukada, So-ichiro; Serrano, Antonio L.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Elsevier, 2015)
    Preservation of cell identity is necessary for homeostasis of most adult tissues. This process is challenged every time a tissue undergoes regeneration after stress or injury. In the lethal Duchenne muscular dystrophy ...
  • Infiltrating myeloid cells and angiogenesis during skeletal muscle regeneration : role of p38γ/δ MAPKs in macrophage-phenotype acquisition
    Martínez García, Antonio, 1992- (Universitat Pompeu Fabra, 2019-12-09)
    I joined the lab of Dra. Pura Muñoz to study the capacity of self-repair of skeletal muscle after an acute injury. During this process many different cell types interact to coordinate and regulate muscle repair. During ...
  • Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
    Hong, Xiaotong; Isern, Joan; Campanario, Silvia; Perdiguero, Eusebio, 1968-; Ramírez Pardo, Ignacio; Segalés Dalmau, Jessica; Hernansanz-Agustín, Pablo; Curtabbi, Andrea; Deryagin, Oleg; Pollán, Angela; González-Reyes, José A.; Villalba, José M.; Sandri, Marco; Serrano Sánchez, Antonio L.; Enríquez, José Antonio; Muñoz Cánoves, Pura, 1962- (Elsevier, 2022)
    Skeletal muscle regeneration depends on the correct expansion of resident quiescent stem cells (satellite cells), a process that becomes less efficient with aging. Here, we show that mitochondrial dynamics are essential ...
  • Musculoskeletal senescence: a moving target ready to be eliminated
    Baar, Marjolein P.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962-; de Keizer, Peter LJ (Elsevier, 2018)
    Aging is the prime risk factor for the broad-based development of diseases. Frailty is a phenotypical hallmark of aging and is often used to assess whether the predicted benefits of a therapy outweigh the risks for older ...
  • p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair
    Perdiguero, Eusebio, 1968-; Sousa-Victor, Pedro; Ruiz Bonilla, Vanesa, 1979-; Jardí, Mercè; Caelles Franch, Carme; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Rockefeller University Press, 2011)
    Repair of damaged tissue requires the coordinated action of inflammatory and tissue-specific cells to restore homeostasis, but the underlying regulatory mechanisms are poorly understood. In this paper, we report new roles ...
  • PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy
    Ardite, Esther; Perdiguero, Eusebio, 1968-; Vidal Iglesias, Berta; Gutarra, Susana; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Rockefeller University Press, 2012)
    There is a widespread awareness that the wealth of preclinical toxicity data that the pharmaceutical industry has generated in recent decades is not exploited as efficiently as it could be. Enhanced data availability for ...
  • Regulation of muscle stem cell functions: a focus on the p38 MAPK signaling pathway
    Segalés Dalmau, Jessica; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Frontiers, 2016)
    Formation of skeletal muscle fibers (myogenesis) during development and after tissue injury in the adult constitutes an excellent paradigm to investigate the mechanisms whereby environmental cues control gene expression ...
  • Rejuvenating stem cells to restore muscle regeneration in aging [version 1; referees: 3 approved]
    Bengal, Eyal; Perdiguero, Eusebio, 1968-; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (F1000Research, 2017)
    Adult muscle stem cells, originally called satellite cells, are essential for muscle repair and regeneration throughout life. Besides a gradual loss of mass and function, muscle aging is characterized by a decline in the ...
  • Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
    Moiseeva, Victoria, 1992-; Cisneros, Andrés; Sica, Valentina; Deryagin, Oleg; Andrés, Eva; Segalés Dalmau, Jessica; Ortet Cortada, Laura; Lukesova, Vera; Serrano Sánchez, Antonio L.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Nature Research, 2023)
    Tissue regeneration requires coordination between resident stem cells and local niche cells1,2. Here we identify that senescent cells are integral components of the skeletal muscle regenerative niche that repress regeneration ...
  • Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
    Segalés Dalmau, Jessica; Perdiguero, Eusebio, 1968-; Serrano, Antonio L.; Sousa-Victor, Pedro; Ortet Cortada, Laura; Jardí, Mercè; Budanov, Andrei V.; García-Prat, Laura, 1987-; Sandri, Marco; Thomson, David M.; Karin, Michael; Hee Lee, Jun; Muñoz Cánoves, Pura, 1962- (Nature Research, 2020)
    A unique property of skeletal muscle is its ability to adapt its mass to changes in activity. Inactivity, as in disuse or aging, causes atrophy, the loss of muscle mass and strength, leading to physical incapacity and poor ...
  • The chromatin remodeling complex Chd4/NuRD controls striated muscle identity and metabolic homeostasis
    Gómez-Del Arco, Pablo; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962-; Redondo, Juan Miguel (Elsevier, 2016)
    Heart muscle maintains blood circulation, while skeletal muscle powers skeletal movement. Despite having similar myofibrilar sarcomeric structures, these striated muscles differentially express specific sarcomere components ...