Browsing by Author "Perálvarez Marín, Alex"

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  • A TRPV2 interactome-based signature for prognosis in glioblastoma patients
    Doñate-Macián, Pau; Gómez, Antonio; Dégano, Irene R.; Perálvarez Marín, Alex (Impact Journal, 2018)
    Proteomics aids to the discovery and expansion of protein-protein interaction networks, which are key to understand molecular mechanisms in physiology and physiopathology, but also to infer protein function in a ...
  • Amyloid-β peptide nitrotyrosination stabilizes oligomers and enhances NMDAR-mediated toxicity
    Guivernau Almazán, Biuse, 1988-; Bonet Martínez, Jaume, 1982-; Valls Comamala, Victòria, 1987-; Bosch Morató, Mònica, 1986-; Godoy Zeballos, Juan Alejandro, 1959-; Inestrosa, Nibaldo C.; Perálvarez Marín, Alex; Fernández-Busquets, Xavier; Andreu Martínez, David; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Society for Neuroscience, 2016)
    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the pathological aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can switch from helicoidal to β-sheet conformation, promoting its ...
  • Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
    Gallego-Villarejo, Lucía; Wallin, Cecilia; Król, Sylwia; Enrich-Bengoa, Jennifer; Suades, Albert; Aguilella-Arzo, Marcel; Gomara, Maria J.; Haro, Isabel; Wärmlander, Sebastian; Muñoz López, Francisco José, 1964-; Gräslund, Astrid; Perálvarez Marín, Alex (Elsevier, 2022)
    Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer's disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since ...
  • Deciphering the genetic crosstalk between microglia and oligodendrocyte precursor cells during demyelination and remyelination using transcriptomic data
    Enrich-Bengoa, Jennifer; Manich, Gemma; Dégano, Irene R.; Perálvarez Marín, Alex (MDPI, 2022)
    Demyelinating disorders show impaired remyelination due to failure in the differentiation of oligodendrocyte progenitor cells (OPCs) into mature myelin-forming oligodendrocytes, a process driven by microglia-OPC crosstalk. ...
  • Human albumin impairs amyloid β-peptide fibrillation through its C-terminus: from docking modeling to protection against neurotoxicity in alzheimer's disease
    Picón-Pagès, Pol; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Garcia-Buendia, Joan; Gutierrez, Daniela; Valle, Javier; Gómez-Casuso, Carmen E.S.; Sidelkivska, Valeriya; Alvarez, Alejandra; Perálvarez Marín, Alex; Suades, Albert; Fernàndez Busquets, Xavier; Andreu Martínez, David; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate ...
  • Peptide assembly on the membrane determines the HIV-1 inhibitory activity of dual-targeting fusion inhibitor peptides
    Gomara, Maria J.; Pérez, Yolanda; Martínez, Javier P.; Barnadas Rodríguez, Ramón; Schultz, Anke; von Briesen, Hagen; Perálvarez Marín, Alex; Meyerhans, Andreas; Haro, Isabel (Nature Research, 2019)
    Novel strategies in the design of HIV-1 fusion/entry inhibitors are based on the construction of dual-targeting fusion proteins and peptides with synergistic antiviral effects. In this work we describe the design of ...
  • Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel
    Berna Erro, Alejandro; Izquierdo Serra, Mercè; Sepúlveda, Romina V.; Rubio Moscardó, Fanny; Doñate-Macián, Pau; Serra Pascual, Selma A., 1981-; Carrillo García, Julia, 1993-; Perálvarez Marín, Alex; González Nilo, Fernando; Fernández-Fernández, José Manuel, 1967-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2017)
    TRPV4 cation channel activation by cytochrome P450-mediated derivatives of arachidonic acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major mechanisms of endothelium-derived vasodilatation. Besides, TRPV4 ...
  • The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers
    Valls Comamala, Victòria, 1987-; Guivernau Almazán, Biuse, 1988-; Bonet Martínez, Jaume, 1982-; Puig, Marta; Perálvarez Marín, Alex; Palomer, Ernest; Fernàndez Busquets, Xavier; Altafaj, Xavier; Tajes Orduña, Marta; Puig Pijoan, Albert; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Impact Journals, 2017)
    The amyloid beta-peptide (Aβ) plays a leading role in Alzheimer's disease (AD) physiopathology. Even though monomeric forms of Aβ are harmless to cells, Aβ can aggregate into β-sheet oligomers and fibrils, which are both ...
  • The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity
    Doñate-Macián, Pau; Jungfleisch, Jennifer, 1986-; Pérez Vilaró, Gemma, 1985-; Rubio Moscardó, Fanny; Perálvarez Marín, Alex; Díez Antón, Juana, 1962-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2018)
    Ion channels are well placed to transduce environmental cues into signals used by cells to generate a wide range of responses, but little is known about their role in the regulation of RNA metabolism. Here we show that the ...
  • Trafficking of stretch-regulated TRPV2 and TRPV4 channels inferred through interactomics
    Doñate-Macián, Pau; Enrich-Bengoa, Jennifer; Dégano, Irene R.; Quintana, David G.; Perálvarez Marín, Alex (MDPI, 2019)
    Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo- and ...

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