Browsing by Author "Peligero Cruz, Cristina, 1986-"

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  • A new model for the estimation of cell proliferation dynamics using CFSE data
    Banks, H. Thomas; Sutton, Karyn L.; Thompson, W. Clayton; Bocharov, Gennady A.; Doumic, Marie; Schenkel, Tim; Argilaguet Marqués, Jordi, 1977-; Giest, Sandra; Peligero Cruz, Cristina, 1986-; Meyerhans, Andreas (Elsevier, 2011)
    CFSE analysis of a proliferating cell population is a popular tool for the study of cell division and divisionlinked changes in cell behavior. Recently Banks et al. (2011), Luzyanina et al. (2009), Luzyanina et al. (2007), ...
  • A novel statistical analysis and interpretation of flow cytometry data
    Banks, H. Thomas; Kapraun, Dustin F.; Thompson, W. Clayton; Peligero Cruz, Cristina, 1986-; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Taylor & Francis (Routledge), 2013)
    A recently developed class of models incorporating the cyton model of population generation structure into a conservation-based model of intracellular label dynamics is reviewed. Statistical aspects of the data collection ...
  • Analysis of variability in estimates of cell proliferation parameters for cyton-based models using CFSE-based flow cytometry data
    Banks, H. Thomas; Kapraun, Dustin F.; Link, Kathryn; Thompson, W. Clayton; Peligero Cruz, Cristina, 1986-; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (De Gruyter, 2015)
    In this article we assess variability in cell proliferation dynamics observed for CD4+ and CD8+ T cells collected from two healthy donors. We review a recently developed class of models that incorporates the so-called ...
  • Calcineurin and mTOR inhibitors have opposing effects on regulatory T cells while reducing regulatory B cell populations in kidney transplant recipients.
    Latorre, Irene; Esteve-Solé, Ana; Redondo Pachón, María Dolores; Giest, Sandra; Argilaguet Marqués, Jordi, 1977-; Álvarez, Sara; Peligero Cruz, Cristina, 1986-; Forstmann, Isabelle; Crespo Barrio, Marta; Pascual Santos, Julio; Meyerhans, Andreas (Elsevier, 2016)
    BACKGROUND: Regulatory B (Breg) and T (Treg) cells represent a biomarker for tolerance in transplant patients. Despite the importance of Treg and Breg in transplantation and the suggested crosstalk between both suppressive ...
  • Evaluating the importance of mitotic asymmetry in cyton-based models for FSE-based flow cytometry data
    Banks, H. Thomas; Kapraun, Dustin F.; Peligero Cruz, Cristina, 1986-; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Academic Publications, 2015)
    We carry out computational inverse problem investigations to determine the importance of allowing for unequal label allocation to daughter cells during mitosis. Parameter estimations are performed using previously developed ...
  • IL18 signaling promotes homing of mature Tregs into the thymus
    Peligero Cruz, Cristina, 1986-; Givony, Tal; Sebé-Pedrós, Arnau; Dobeš, Jan; Kadouri, Noam; Nevo, Shir; Roncato, Francesco; Alon, Ronen; Goldfarb, Yael; Abramson, Jakub (eLife, 2020)
    Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance of immune homeostasis. Most Tregs develop in the thymus and are then released into the immune periphery. However, some Tregs ...
  • PD-L1 blockade differentially impacts regulatory T cells from HIV-infected individuals depending on plasma viremia
    Peligero Cruz, Cristina, 1986-; Argilaguet Marqués, Jordi, 1977-; Güerri Fernández, Roberto; Torres, Berta; Ligero, Carmen; Colomer, Pilar; Plana, Montserrat; Knobel Freud, Hernando; García, Felipe; Meyerhans, Andreas (Public Library of Science (PLoS), 2015)
    Blocking the PD-1/PD-L1 pathway has emerged as a potential therapy to restore impaired immune responses in human immunodeficiency virus (HIV)-infected individuals. Most reports have studied the impact of the PD-L1 blockade ...
  • Prediction of PD-L1 inhibition effects for HIV-infected individuals
    Zheltkova, Valerya; Argilaguet Marqués, Jordi, 1977-; Peligero Cruz, Cristina, 1986-; Bocharov, Gennady A.; Meyerhans, Andreas (Public Library of Science (PLoS), 2019)
    The novel therapies with immune checkpoint inhibitors hold great promises for patients with chronic virus infections and cancers. This is based mainly on the partial reversal of the exhausted phenotype of antigen-specific ...
  • Systems analysis reveals complex biological processes during virus infection fate decisions
    Argilaguet Marqués, Jordi, 1977-; Pedragosa Marín, Mireia, 1988-; Esteve-Codina, Anna; Riera Domínguez, María Graciela, 1987-; Vidal Barba, Enric; Peligero Cruz, Cristina, 1986-; Casella, Valentina, 1991-; Andreu Martínez, David; Kaisho, Tsuneyasu; Bocharov, Gennady A.; Ludewig, Burkhard; Heath, Simon; Meyerhans, Andreas (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)
    The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune ...

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