Browsing by Author "Peiró Sales, Sandra"

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  • Frigola, Joan; Iturbide Martínez de Albéniz, Ane, 1989-; López Bigas, Núria; Peiró Sales, Sandra; González-Pérez, Abel (Impact Journals, 2016)
    Chromatin regulatory factors (CRFs), are known to be involved in tumorigenesis in several cancer types. Nevertheless, the molecular mechanisms through which driver alterations of CRFs cause tumorigenesis remain unknown. ...
  • Escrivà Izquierdo, María (Universitat Pompeu Fabra, 2008-06-20)
    The product of the snail1 gene (SNAIL1) is a transcriptional repressor required for triggering the epithelial-to-mesenchymal transition (EMT). SNAIL1 transcription is induced when epithelial cells are forced to acquire a ...
  • Pascual-Reguant, Laura, 1990- (Universitat Pompeu Fabra, 2018-11-23)
    Les làmines nuclears (A/C i B) són els majors constituents de la làmina nuclear (NL). Els estructuralment conservats dominis associats a les làmines (LADs) estan formats per regions genòmiques que contacten amb la NL. Tot ...
  • Cebrià i Costa, Joan Pau, 1989- (Universitat Pompeu Fabra, 2017-06-29)
    L’oxidació de la histona 3 en la lisina 4 (H3K4ox) per acció de la lysil oxidase-like 2 (LOXL2) genera una nova modificació de la H3 amb una funció desconeguda. En aquesta tesi, hem determinat tant en línies cel·lulars com ...
  • Millanes Romero, Alba, 1986- (Universitat Pompeu Fabra, 2014-01-21)
    Although heterochromatin is enriched with repressive traits, it is actively transcribed, giving rise to large amounts of non-coding RNAs. These transcripts are responsible for the formation and maintenance of heterochromatin, ...
  • Iturbide Martínez de Albéniz, Ane, 1989- (Universitat Pompeu Fabra, 2016-03-15)
    Protein function is often regulated and controlled by posttranslational modifications, such as oxidation. Although oxidation has been mainly considered to be uncontrolled and nonenzymatic, many enzymatic oxidations occur ...
  • Pascual-Reguant, Laura; Blanco, Enrique; Galan, Silvia; Le Dily, François; Cuartero, Yasmina; Serra-Bardenys, Gemma; Di Carlio, Valerio; Iturbide Martínez de Albéniz, Ane, 1989-; Cebrià i Costa, Joan Pau, 1989-; Nonell Mazelón, Lara; García de Herreros, Antonio; Di Croce, Luciano; Marti-Renom, Marc A.; Peiró Sales, Sandra (Nature Publishing Group, 2018)
    Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, ...
  • Iturbide Martínez de Albéniz, Ane, 1989-; Pascual-Reguant, Laura; Fargas Madriles, Laura, 1989-; Cebrià i Costa, Joan Pau, 1989-; Alsina i Español, Berta; García de Herreros, Antonio; Peiró Sales, Sandra (Elsevier, 2015)
    Protein function is often regulated and controlled by posttranslational modifications, such as oxidation. Although oxidation has been mainly considered to be uncontrolled and nonenzymatic, many enzymatic oxidations occur ...
  • Herranz Martín, Nicolás; Dave, Natàlia; Millanes Romero, Alba, 1986-; Morey Ramonell, Lluís; Díaz, Víctor M.; Lórenz Fonfria, Víctor; Gutiérrez Gallego, Ricardo, 1968-; Jerónimo, Celia; Di Croce, Luciano; García de Herreros, Antonio; Peiró Sales, Sandra (American Society for Cell Biology, 2012)
    Methylation of lysine 4 (K4) within histone H3 has been linked to active transcription and is removed by LSD1 and the JmjC domain-containing proteins by amino-oxidation or hydroxylation, respectively. Here, we describe the ...
  • Herranz Martín, Nicolás (Universitat Pompeu Fabra, 2011-09-23)
    The epithelial to mesenchymal transition (EMT) is a highly conserved cellular program that allows well-­‐differentiated epithelial cells to convert to motile mesenchymal cells. EMT is critical for appropriate embryogenes ...
  • Serra Bardenys, Gemma, 1992- (Universitat Pompeu Fabra, 2019-12-12)
    Oxidation of histone H3 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) is important in triple-negative breast cancer (TNBC) cells to generate compacted heterochromatin regions. However, the molecular mechanisms by which it ...
  • Millanes Romero, Alba, 1986-; Herranz Martín, Nicolás; Perrera, Valentina; Iturbide Martínez de Albéniz, Ane, 1989-; Loubat Casanovas, Jordina, 1982-; Jenuwein, Thomas; García de Herreros, Antonio; Peiró Sales, Sandra (Elsevier, 2013)
    Although heterochromatin is enriched with repressive traits, it is also actively transcribed, giving rise to large amounts of noncoding RNAs. Although these RNAs are responsible for the formation and maintenance of ...
  • Mazzolini, Rocco; Gonzàlez Busqué, Núria, 1980-; Garcia-Garijo, Andrea; Millanes Romero, Alba, 1986-; Peiró Sales, Sandra; Smith, Susan; García de Herreros, Antonio; Canudas i Puig, Sílvia (Oxford University Press, 2018)
    Besides controlling epithelial-to-mesenchymal transition (EMT) and cell invasion, the Snail1 transcriptional factor also provides cells with cancer stem cell features. Since telomere maintenance is essential for stemness, ...
  • Beltran, Manuel; Aparicio i Prat, Estel, 1986-; Mazzolini, Rocco; Millanes Romero, Alba, 1986-; Massó, Pere; Jenner, Richard G.; Díaz, Víctor M.; Peiró Sales, Sandra; García de Herreros, Antonio (Oxford University Press, 2015)
    In this report we have analyzed the role of antisense transcription in the control of LEF1 transcription factor expression. A natural antisense transcript (NAT) is transcribed from a promoter present in the first intron ...
  • Verde, Gaetano; De Llobet, Lara Isabel; Wright, Roni H.G.; Quilez Oliete, Javier; Peiró Sales, Sandra; Le Dily, François; Beato, Miguel (MDPI, 2018)
    Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the estrogen and progesterone receptors (ER and PR, respectively). Although much is known about ERα gene (ESR1) regulation ...