Browsing by Author "Peiró Sales, Sandra"

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  • Altered oncomodules underlie chromatin regulatory factors driver mutations.
    Frigola, Joan; Iturbide Martínez de Albéniz, Ane, 1989-; López Bigas, Núria; Peiró Sales, Sandra; González-Pérez, Abel (Impact Journals, 2016)
    Chromatin regulatory factors (CRFs), are known to be involved in tumorigenesis in several cancer types. Nevertheless, the molecular mechanisms through which driver alterations of CRFs cause tumorigenesis remain unknown. ...
  • Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity
    Torcal Garcia, Guillem, 1991-; Kowenz-Leutz, Elisabeth; Tian, Tian V.; Klonizakis, Antonios; Lerner, Jonathan; Andrés Aguayo, Luisa de; Sapozhnikova, Valeriia; Berenguer, Clara; Plana Carmona, Marcos, 1993-; Vila-Casadesús, Maria; Bulteau, Romain; Francesconi, Mirko; Peiró Sales, Sandra; Mertins, Philipp; Zaret, Kenneth S.; Leutz, Achim; Graf, T. (Thomas) (eLife, 2023)
    Here, we describe how the speed of C/EBPα-induced B cell to macrophage transdifferentiation (BMT) can be regulated, using both mouse and human models. The identification of a mutant of C/EBPα (C/EBPαR35A) that greatly ...
  • Characterization of snail1 and pten transcriptional regulation by snail1: New insights into epithelial-to-mesenchymal transition and cell resistance to apoptosis
    Escrivà Izquierdo, María (Universitat Pompeu Fabra, 2008-06-20)
    The product of the snail1 gene (SNAIL1) is a transcriptional repressor required for triggering the epithelial-to-mesenchymal transition (EMT). SNAIL1 transcription is induced when epithelial cells are forced to acquire a ...
  • Chromatin reorganization during epithelial-to-mesenchymal transition : a role for euchromatin lamin B1 domains
    Pascual-Reguant, Laura (Universitat Pompeu Fabra, 2019-02-01)
    Les làmines nuclears (A/C i B) són els majors constituents de la làmina nuclear (NL). Els estructuralment conservats dominis associats a les làmines (LADs) estan formats per regions genòmiques que contacten amb la NL. Tot ...
  • H3K4ox a new epigenetic mark : characterization of H3K4ox as a new epigenetic mark and its role in chomatin condensation
    Cebrià i Costa, Joan Pau, 1989- (Universitat Pompeu Fabra, 2017-06-29)
    L’oxidació de la histona 3 en la lisina 4 (H3K4ox) per acció de la lysil oxidase-like 2 (LOXL2) genera una nova modificació de la H3 amb una funció desconeguda. En aquesta tesi, hem determinat tant en línies cel·lulars com ...
  • Heterochromatin dynamics during epithelial-to-mesenchymal transition
    Millanes Romero, Alba, 1986- (Universitat Pompeu Fabra, 2014-01-21)
    Although heterochromatin is enriched with repressive traits, it is actively transcribed, giving rise to large amounts of non-coding RNAs. These transcripts are responsible for the formation and maintenance of heterochromatin, ...
  • Identification of new LOXL2 substrates : a role for lysine oxidation in embryonic stem cell differentiation
    Iturbide Martínez de Albéniz, Ane, 1989- (Universitat Pompeu Fabra, 2017-11-20)
    Protein function is often regulated and controlled by posttranslational modifications, such as oxidation. Although oxidation has been mainly considered to be uncontrolled and nonenzymatic, many enzymatic oxidations occur ...
  • Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
    Pascual-Reguant, Laura; Blanco, Enrique; Galan Martínez, Silvia, 1992-; Le Dily, François; Cuartero, Yasmina; Serra Bardenys, Gemma, 1992-; Di Carlo, Valerio; Iturbide Martínez de Albéniz, Ane, 1989-; Cebrià i Costa, Joan Pau, 1989-; Nonell Mazelón, Lara; García de Herreros, Antonio; Di Croce, Luciano; Marti-Renom, Marc A.; Peiró Sales, Sandra (Nature Publishing Group, 2018)
    Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, ...
  • LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation
    Iturbide Martínez de Albéniz, Ane, 1989-; Pascual-Reguant, Laura; Fargas Madriles, Laura, 1989-; Cebrià i Costa, Joan Pau, 1989-; Alsina i Español, Berta; García de Herreros, Antonio; Peiró Sales, Sandra (Elsevier, 2015)
    Protein function is often regulated and controlled by posttranslational modifications, such as oxidation. Although oxidation has been mainly considered to be uncontrolled and nonenzymatic, many enzymatic oxidations occur ...
  • LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells
    Cebrià i Costa, Joan Pau, 1989-; Pascual-Reguant, Laura; Gonzalez-Perez, Abel; Serra Bardenys, Gemma, 1992-; Querol, J.; Cosín, M.; Verde, Gaetano; Cigliano, Riccardo Aiese; Sanseverino, Walter; Segura-Bayona, Sandra; Iturbide Martínez de Albéniz, Ane, 1989-; Andreu Martínez, David; Nuciforo, Paolo G.; Bernado-Morales, C.; Rodilla, Verónica; Arribas, Joaquín; Yélamos López, José; García de Herreros, Antonio; Stracker, Travis; Peiró Sales, Sandra (Nature Research, 2020)
    Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) ...
  • Lysyl oxidase-like 2 deaminates lysine 4 in histone H3
    Herranz Martín, Nicolás; Dave, Natàlia; Millanes Romero, Alba, 1986-; Morey Ramonell, Lluís; Díaz, Víctor M.; Lórenz Fonfria, Víctor; Gutiérrez Gallego, Ricardo, 1968-; Jerónimo, Celia; Di Croce, Luciano; García de Herreros, Antonio; Peiró Sales, Sandra (American Society for Cell Biology, 2012)
    Methylation of lysine 4 (K4) within histone H3 has been linked to active transcription and is removed by LSD1 and the JmjC domain-containing proteins by amino-oxidation or hydroxylation, respectively. Here, we describe the ...
  • New insights in the epigenetic control of EMT
    Herranz Martín, Nicolás (Universitat Pompeu Fabra, 2011-09-23)
    The epithelial to mesenchymal transition (EMT) is a highly conserved cellular program that allows well-­‐differentiated epithelial cells to convert to motile mesenchymal cells. EMT is critical for appropriate embryogenes ...
  • New insights into the role of oxidized histone H3 in heterochromatin
    Serra Bardenys, Gemma (Universitat Pompeu Fabra, 2020-01-07)
    Oxidation of histone H3 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) is important in triple-negative breast cancer (TNBC) cells to generate compacted heterochromatin regions. However, the molecular mechanisms by which it ...
  • Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition
    Millanes Romero, Alba, 1986-; Herranz Martín, Nicolás; Perrera, Valentina; Iturbide Martínez de Albéniz, Ane, 1989-; Loubat Casanovas, Jordina, 1982-; Jenuwein, Thomas; García de Herreros, Antonio; Peiró Sales, Sandra (Elsevier, 2013)
    Although heterochromatin is enriched with repressive traits, it is also actively transcribed, giving rise to large amounts of noncoding RNAs. Although these RNAs are responsible for the formation and maintenance of ...
  • Snail1 transcription factor controls telomere transcription and integrity
    Mazzolini, Rocco; Gonzàlez Busqué, Núria, 1980-; Garcia-Garijo, Andrea; Millanes Romero, Alba, 1986-; Peiró Sales, Sandra; Smith, Susan; García de Herreros, Antonio; Canudas i Puig, Sílvia (Oxford University Press, 2018)
    Besides controlling epithelial-to-mesenchymal transition (EMT) and cell invasion, the Snail1 transcriptional factor also provides cells with cancer stem cell features. Since telomere maintenance is essential for stemness, ...
  • Splicing of a non-coding antisense transcript controls LEF1 gene expression.
    Beltran, Manuel; Aparicio i Prat, Estel, 1986-; Mazzolini, Rocco; Millanes Romero, Alba, 1986-; Massó, Pere; Jenner, Richard G.; Díaz, Víctor M.; Peiró Sales, Sandra; García de Herreros, Antonio (Oxford University Press, 2015)
    In this report we have analyzed the role of antisense transcription in the control of LEF1 transcription factor expression. A natural antisense transcript (NAT) is transcribed from a promoter present in the first intron ...
  • Unliganded progesterone receptor governs estrogen receptor gene expression by regulating DNA methylation in breast cancer cells
    Verde, Gaetano; De Llobet, Lara Isabel; Wright, Roni H.G.; Quilez Oliete, Javier; Peiró Sales, Sandra; Le Dily, François; Beato, Miguel (MDPI, 2018)
    Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the estrogen and progesterone receptors (ER and PR, respectively). Although much is known about ERα gene (ESR1) regulation ...