Browsing by Author "Pastore, Annalisa"

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  • Aggregation is a context-dependent constraint on protein evolution
    Monti, Michele; Armaos, Alexandros, 1989-; Fantini, Marco; Pastore, Annalisa; Tartaglia, Gian Gaetano (Frontiers, 2021)
    Solubility is a requirement for many cellular processes. Loss of solubility and aggregation can lead to the partial or complete abrogation of protein function. Thus, understanding the relationship between protein evolution ...
  • Homage to Chris Dobson
    Baum, Jean; Chiti, Fabrizio; de Simone, Alfonso; Knowles, Tuomas P.J.; Kumita, Janet R.; Radford, Sheena E.; Robinson, Carol V.; Salvatella, Xavier; Valelli, Karen; Vendruscolo, Michele; Pastore, Annalisa; Tartaglia, Gian Gaetano (Frontiers, 2019)
  • RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43
    Zacco, Elsa; Graña-Montes, Ricardo; Martin, Stephen R.; Sanchez de Groot, Natalia; Alfano, Caterina; Tartaglia, Gian Gaetano; Pastore, Annalisa (Elsevier, 2019)
    Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are incurable motor neuron diseases associated with muscle weakness, paralysis and respiratory failure. Accumulation of TAR DNA-binding protein 43 (TDP-43) ...
  • RNA as the stone guest of protein aggregation
    Louka, Alexandra; Zacco, Elsa; Temussi, Piero Andrea; Tartaglia, Gian Gaetano; Pastore, Annalisa (Oxford University Press, 2020)
    The study of prions as infectious aggregates dates several decades. From its original formulation, the definition of a prion has progressively changed to the point that many aggregation-prone proteins are now considered ...