Browsing by Author "Pastor, Antonio"

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  • A lower olfactory capacity is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body Mass index in women.
    Pastor, Antonio; Fernández Aranda, Fernando; Fitó Colomer, Montserrat; Jiménez Murcia, Susana; Botella, Cristina; Fernández Real, Jose M.; Frühbeck, Gema; Tinahones Madueño, Francisco José; Fagundo, Ana B.; Rodríguez Rodríguez, Juan Francisco; Agüera, Zaida; Langohr, Klaus; Casanueva, Felipe F.; Torre Fornell, Rafael de la (Public Library of Science , 2016)
    The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in ...
  • Acetaminophen-induced liver injury alters the Acyl ethanolamine-based anti-inflammatory signaling system in liver
    Rivera, Patricia; Pastor, Antonio; Arrabal, Sergio; Decara, Juan M.; Vargas, Antonio; Sánchez-Marín, Laura; Pavón, Francisco Javier; Serrano, Antonia; Bautista, Dolores; Boronat Rigol, Anna, 1990-; Torre Fornell, Rafael de la; Baixeras, Elena; Lucena, Maria Isabel; Rodríguez de Fonseca, Fernando; Suárez, Juan (Frontiers, 2017)
    Protective mechanisms against drug-induced liver injury are actively being searched to identify new therapeutic targets. Among them, the anti-inflammatory N-acyl ethanolamide (NAE)-peroxisome proliferators activated receptor ...
  • Analysis of free hydroxytyrosol in human plasma following the administration of olive oil.
    Pastor, Antonio; Rodríguez-Morató, Jose, 1987-; Olesti Muñoz, Eulàlia, 1991-; Pujadas Bastardes, Mitona; Pérez Mañá, Clara; Khymenets, Olha, 1974-; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Solà, Rosa; Motilva, Maria-José; Farré Albaladejo, Magí; Torre Fornell, Rafael de la (Elsevier, 2016)
    Hydroxytyrosol (HT) from olive oil, a potent bioactive molecule with health benefits, has a poor bioavailability, its free form (free HT) being undetectable so far. This fact leads to the controversy whether attained HT ...
  • Application of the athlete biological passport approach to the detection of growth hormone doping
    Equey, Tristan; Pastor, Antonio; Torre Fornell, Rafael de la; Thomas, Andreas; Giraud, Sylvain; Thevis, Mario; Kuuranne, Tiia; Baume, Norbert; Barroso, Osquel; Aikin, Reid (Oxford University Press, 2022)
    Context: because of its anabolic and lipolytic properties, growth hormone (GH) use is prohibited in sport. Two methods based on population-derived decision limits are currently used to detect human GH (hGH) abuse: the hGH ...
  • Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity
    Baenas, Isabel; Miranda-Olivos, Romina; Granero, Roser; Solé Morata, Neus, 1988-; Sánchez, Isabel; Pastor, Antonio; Pino-Gutiérrez, Amparo del; Codina, Ester; Tinahones Madueño, Francisco José; Fernández-Formoso, José A.; Vilarrasa, Nuria; Guerrero-Pérez, Fernando; Lopez-Urdiales, Rafael; Virgili, Núria; Soriano-Mas, Carles; Jiménez Murcia, Susana; Torre Fornell, Rafael de la; Fernández Aranda, Fernando (Cambridge University Press, 2023)
    Background: Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food and energy metabolism. Aberrant functioning of the endocannabinoid system has been observed ...
  • Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome
    Navarro Romero, Alba, 1990-; Galera López, Lorena, 1993-; Ortiz Romero, Paula, 1994-; Llorente-Ovejero, Alberto; Los Reyes-Ramírez, Lucía de; Bengoetxea de Tena, Iker; Garcia-Elias Heras, Anna; Mas-Stachurska, Aleksandra; Reixachs i Solé, Marina; Pastor, Antonio; Torre Fornell, Rafael de la; Maldonado, Rafael, 1961-; Benito Villabriga, Begoña; Eyras Jiménez, Eduardo; Rodríguez-Puertas, Rafael; Campuzano Uceda, María Victoria; Ozaita Mintegui, Andrés, 1969- (eLife, 2022)
    Williams-Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular ...
  • Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome
    Navarro-Romero, Alba; Vázquez-Oliver, Anna; Gomis González, Maria, 1988-; Garzón-Montesinos, Carlos; Falcón-Moya, Rafael; Pastor, Antonio; Martín García, Elena, 1975-; Pizarro Lozano, Mª Nieves; Busquets Garcia, Arnau, 1985-; Revest, Jean-Michel; Piazza, Pier Vincenzo; Bosch, Fatima; Dierssen, Mara; Torre Fornell, Rafael de la; Rodríguez-Moreno, Antonio; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)
    Intellectual disability is the most limiting hallmark of Down syndrome, for which there is no gold-standard clinical treatment yet. The endocannabinoid system is a widespread neuromodulatory system involved in multiple ...
  • CB1 cannabinoid receptors mediate cognitive deficits and structural plasticity changes during nicotine withdrawal
    Saravia Santos, Rocio, 1988-; Flores de los Heros, África, 1985-; Plaza-Zabala, Ainhoa, 1982-; Busquets Garcia, Arnau, 1985-; Pastor, Antonio; Torre Fornell, Rafael de la; Di Marzo, Vicenzo; Marsicano, Giovanni; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2017)
    BACKGROUND: Tobacco withdrawal is associated with deficits in cognitive function, including attention, working memory, and episodic memory. Understanding the neurobiological mechanisms involved in these effects is crucial ...
  • Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors.
    Viñals Álvarez, Xavier, 1985-; Moreno, Estefanía; Lanfumey, Laurence; Cordomí, Arnau; Pastor, Antonio; Torre Fornell, Rafael de la; Gasperini, Paola; Navarro, Gemma; Howell, Lesley A.; Pardo, Leonardo; Lluís, Carmen; Canela, Enric I.; McCormick, Peter J.; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958- (Public Library of Science, 2015)
    Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of ...
  • Comorbilidad psiquiátrica y valores plasmáticos de 2-acilgliceroles en consumidores de alcohol en tratamiento ambulatorio. Análisis de las diferencias de género
    García Marchena, Nuria; Araos, Pedro; Pavón, Francisco Javier; Ponce, Guillermo; Pedraz, María; Serrano, Antonia; Arias, Francisco; Romero Sanchiz, Pablo; Suárez, Juan; Pastor, Antonio; Torre Fornell, Rafael de la; Torrens, Marta; Rubio, Gabriel; Rodríguez de Fonseca, Fernando (Sociedad Científica Española de Estudios sobre el Alcohol, el Alcoholismo y las otras Toxicomanías, 2017)
    La adicción al alcohol se asocia con una elevada comorbilidad psiquiátrica que complica el tratamiento, siendo necesaria una fenotipación clínica objetiva de estos pacientes para optimizar la atención y mejorar el pronóstico. ...
  • Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response
    Fonseca Casals, Francina, 1972-; Torre Fornell, Rafael de la; Díaz, Laura; Pastor, Antonio; Cuyàs, Elisabet; Pizarro Lozano, Mª Nieves; Khymenets, Olha, 1974-; Farré Albaladejo, Magí; Torrens, Marta (Public Library of Science (PLoS), 2011)
    Although the efficacy of methadone maintenance treatment (MMT) in opioid dependence disorder has been well established, the influence of methadone pharmacokinetics in dose requirement and clinical outcome remains controversial. ...
  • Determination of oleanolic acid in human plasma and its association with olive oil intake in healthy Spanish adults within the EPIC Spain cohort study
    Buckland, Genevieve; Pastor, Antonio; Lujan Barroso, Leila; González Svatetz, Carlos Alberto; Travier, Noemie; Amiano, Pilar; Huerta, José María; Agudo Trigueros, Antonio; Navarro, Carmen; Chirlaque, María Dolores; Sánchez, María José; Rodríguez Barranco, Miguel; Barricarte, Aurelio; Ardanaz Aicua, Eva; Dorronsoro, Miren; Molinuevo, Amaia; Quirós, José Ramón; Torre Fornell, Rafael de la (Wiley-Blackwell, 2017)
    SCOPE: Oleanolic acid (OA) is an important triterpenic compound found in olive oil, however little is known about its concentrations in human plasma. We aimed to determine plasma OA levels in a healthy Spanish population ...
  • Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
    Miranda-Olivos, Romina; Baenas, Isabel; Steward, Trevor; Granero, Roser; Pastor, Antonio; Sánchez, Isabel; Juaneda-Seguí, Asier; Pino-Gutiérrez, Amparo del; Fernández-Formoso, José A.; Vilarrasa, Nuria; Guerrero-Pérez, Fernando; Virgili, Núria; López-Urdiales, Rafael; Jiménez Murcia, Susana; Torre Fornell, Rafael de la; Soriano Mas, Carles; Fernández Aranda, Fernando (Nature Research, 2023)
    Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens ...
  • Maternal separation increases alcohol-drinking behaviour and reduces endocannabinoid levels in the mouse striatum and prefrontal cortex
    Portero Tresserra, Marta; Gracia Rubio, Irene, 1986-; Cantacorps Centellas, Lídia, 1991-; Pozo Mendoza, Óscar J., 1975-; Gomez-Gomez, Àlex; Pastor, Antonio; López Arnau, Raúl; Torre Fornell, Rafael de la; Valverde Granados, Olga (Elsevier, 2018)
    Childhood adversity is associated with an increased risk of mood, anxiety and substance use disorders. Maternal separation is a reliable rodent model of early life adversity that leads to depression-like symptoms, which ...
  • Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol
    Rodríguez-Morató, Jose, 1987-; Boronat Rigol, Anna, 1990-; Kotronoulas, Aristotelis; Pujadas Bastardes, Mitona; Pastor, Antonio; Olesti Muñoz, Eulàlia, 1991-; Pérez Mañá, Clara; Khymenets, Olha, 1974-; Fitó Colomer, Montserrat; Farré Albaladejo, Magí; Torre Fornell, Rafael de la (Taylor & Francis, 2016)
    Hydroxytyrosol and tyrosol are dietary phenolic compounds present in virgin olive oil and wine. Both compounds are also endogenously synthesized in our body as byproducts of dopamine and tyramine metabolisms, respectively. ...
  • Moderate-vigorous physical activity across body mass index in females: moderating effect of endocannabinoids and temperament
    Fernández Aranda, Fernando; Sauchelli, Sarah; Pastor, Antonio; González, Marcela L.; Torre Fornell, Rafael de la; Granero, Roser; Jiménez Murcia, Susana; Baños, Rosa M.; Botella, Cristina; Fernández Real, Jose M.; Fernández García, José C.; Frühbeck, Gema; Gómez Ambrosi, Javier; Rodríguez, Roser; Tinahones Madueño, Francisco José; Arcelus, Jon; Fagundo, Ana B.; Agüera, Zaida; Miró, Jordi; Casanueva, Felipe F. (Public Library of Science (PLoS), 2014)
    Background: Endocannabinoids and temperament traits have been linked to both physical activity and body mass index (BMI) however no study has explored how these factors interact in females. The aims of this cross-sectional ...
  • Modulation of Higher-Order Olfaction Components on Executive Functions in Humans.
    Fagundo, Ana B.; Jiménez Murcia, Susana; Giner Bartolomé, Cristina; Anisul Islam, Mohammed; Torre Fornell, Rafael de la; Pastor, Antonio; Casanueva, Felipe F.; Crujeiras, Ana B.; Granero, Roser; Baños, Rosa M.; Botella, Cristina; Fernández Real, Jose M.; Frühbeck, Gema; Gómez Ambrosi, Javier; Menchón, José M.; Tinahones Madueño, Francisco José; Fernández Aranda, Fernando (Public Library of Science, 2015)
    The prefrontal (PFC) and orbitofrontal cortex (OFC) appear to be associated with both executive functions and olfaction. However, there is little data relating olfactory processing and executive functions in humans. The ...
  • Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans
    Fagundo, Ana B.; Torre Fornell, Rafael de la; Jiménez Murcia, Susana; Agüera, Zaida; Pastor, Antonio; Casanueva, Felipe F.; Granero, Roser; Baños, Rosa M.; Botella, Cristina; de Pino Gutiárrez, Amparo; Fernández Real, Jose M.; Fernández García, José C.; Frühbeck, Gema; Gómez Ambrosi, Javier; Menchón, José M.; Moragrega, Inés; Rodríguez, Roser; Tárrega, Salomé; Tinahones Madueño, Francisco José; Fernández Aranda, Fernando (Public Library of Science (PLoS), 2013)
    Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) ...
  • Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2
    Martínez-Torres, Sara; Cutando Ruiz, Laura, 1985-; Pastor, Antonio; Kato, Ako; Sakimura, Kenji; Torre Fornell, Rafael de la; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Kano, Masanobu; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)
    Monoacylglycerol lipase (MAGL) is the main enzyme implicated in the degradation of the most abundant endocannabinoid in the brain, 2-arachidonoylglycerol (2-AG), producing arachidonic acid (AA) and glycerol. MAGL pharmacological ...
  • Non-linear formation of EtG and FAEEs after controlled administration of low to moderate doses of ethanol
    Pérez Mañá, Clara; Farré Albaladejo, Magí; Pastor, Antonio; Fonseca Casals, Francina, 1972-; Torrens, Marta; Menoyo Colomer, Esther; Pujadas Bastardes, Mitona; Frias, Silvia; Langohr, Klaus; Torre Fornell, Rafael de la (Oxford University Press, 2017)
    AIMS: Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) are non-oxidative metabolites of alcohol that can be detected in conventional and non-conventional biological matrices for longer periods than alcohol. The ...

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