Browsing by Author "Pasquali, Lorenzo"

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  • Colli, Maikel Luis; Ramos-Rodríguez, Mireia; Raurell Vila, Helena; Pasquali, Lorenzo; Eizirik, Décio L. (Nature Research, 2020)
    Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. We ...
  • Bueno-Costa, Alberto; Piñeyro, David; Soler, Marta; Javierre, Biola M.; Raurell Vila, Helena; Subirana-Granés, Marc; Pasquali, Lorenzo; Martinez-Climent, Jose A.; Esteller, Manel (Nature Research, 2020)
  • Fontcuberta-PiSunyer, Marta; García-Alamán, Ainhoa; Prades, Èlia; Téllez, Noèlia; Alves-Figueiredo, Hugo; Ramos-Rodríguez, Mireia; Enrich, Carlos; Fernandez-Ruiz, Rebeca; Cervantes, Sara; Clua, Laura; Ramón-Azcón, Javier; Broca, Christophe; Wojtusciszyn, Anne; Montserrat Pulido, Núria; Pasquali, Lorenzo; Novials, Anna; Servitja, Joan-Marc; Vidal Alaball, Josep; Gomis, Ramon; Gasa, Rosa (Nature Research, 2023)
    Direct lineage reprogramming of one somatic cell into another without transitioning through a progenitor stage has emerged as a strategy to generate clinically relevant cell types. One cell type of interest is the pancreatic ...
  • Arroyo, Noelia; Villamayor, Laura; Díaz, Irene; Carmona, Rita; Ramos-Rodríguez, Mireia; Muñoz-Chápuli, Ramón; Pasquali, Lorenzo; Toscano, Miguel G.; Martín, Franz; Cano, David A.; Rojas, Anabel (American Society for Clinical Investigation, 2021)
    In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either ...
  • Corujo, David; Malinverni, Roberto; Carrillo-Reixach, Juan; Meers, Oliver; Garcia-Jaraquemada, Arce; Le Pannérer, Marguerite-Marie, 1990-; Valero, Vanesa; Pérez, Ainhoa; Del Río-Álvarez, Álvaro; Royo, Laura; Pérez-González, Beatriz; Raurell Vila, Helena; Acemel, Rafael D.; Santos-Pereira, José M.; Gómez Skarmeta, José Luis; Pasquali, Lorenzo; Manyé, Josep; Armengol, Carolina; Buschbeck, Marcus (Elsevier, 2022)
    MacroH2A histone variants have a function in gene regulation that is poorly understood at the molecular level. We report that macroH2A1.2 and macroH2A2 modulate the transcriptional ground state of cancer cells and how they ...
  • Sarkar, Soumyadeep; Ramos-Rodríguez, Mireia; Juan-Mateu, Jonàs; Pasquali, Lorenzo; Nakayasu, Ernesto S. (BioMed Central, 2024)
    Background: Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream ...
  • Ramos-Rodríguez, Mireia; Raurell Vila, Helena; Colli, Maikel Luis; Alvelos, Maria Inês; Subirana-Granés, Marc; Juan-Mateu, Jonàs; Norris, Richard; Turatsinze, Jean-Valery; Nakayasu, Ernesto S.; Webb-Robertson, Bobbie-Jo M.; Inshaw, Jamie R. J.; Marchetti, Piero; Piemonti, Lorenzo; Esteller, Manel; Todd, John A.; Metz, Thomas O.; Eizirik, Décio L.; Pasquali, Lorenzo (Nature Research, 2019)
    The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show that exposure to proinflammatory cytokines reveals a ...
  • Mularoni, Loris; Ramos-Rodríguez, Mireia; Pasquali, Lorenzo (Frontiers, 2017)
    The pancreatic islet is a highly specialized tissue embedded in the exocrine pancreas whose primary function is that of controlling glucose homeostasis. Thus, understanding the transcriptional control of islet-cell may ...
  • Ramos-Rodríguez, Mireia; Pérez-González, Beatriz; Pasquali, Lorenzo (Springer, 2021)
    Purpose of review: Type 1 diabetes (T1D) develops as a consequence of a combination of genetic predisposition and environmental factors. Combined, these events trigger an autoimmune disease that results in progressive loss ...
  • Ramos-Rodríguez, Mireia; Subirana-Granés, Marc; Pasquali, Lorenzo (Oxford University Press, 2021)
    Motivation: UMI-4C, a technique that combines chromosome conformation capture (4C) and unique molecular identifiers (UMI), is widely used to profile and quantitatively compare targeted chromosomal contact profiles. The ...

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