Browsing by Author "Pascual Guàrdia, Sergi, 1979-"

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  • A detailed analysis of possible efficacy signals of NTHi-Mcat vaccine against severe COPD exacerbations in a previously reported randomised phase 2b trial
    Arora, Ashwani K.; Chinsky, Kenneth; Keller, Claus; Mayers, Irvin; Pascual Guàrdia, Sergi, 1979-; Pérez Vera, Mercè; Lambert, Christophe; Lombardi, Stefano; Rondini, Simona; Tian, Suan; Ulloa-Montoya, Fernando; Moraschini, Luca; Casula, Daniela; NTHi-Mcat-002 study group (Elsevier, 2022)
    Background: An investigational vaccine containing non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) surface proteins did not show vaccine efficacy (VE) against combined moderate and severe ...
  • Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients
    Pascual Guàrdia, Sergi, 1979-; Ataya Fernández, Michelle, 1993-; Ramírez Martínez, Isabel; Yélamos López, José; Chalela Rengifo, Roberto José, 1985-; Bellido, Salomé; López-Botet, Miguel; Gea Guiral, Joaquim (BioMed Central, 2020)
    Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive disorder with a heterogeneous presentation and frequent systemic manifestations. Several aspects like persistence in smoking habit, ...
  • Add-on inhaled budesonide in the treatment of hospitalised patients with COVID-19: a randomised clinical trial
    Agustí, Alvar; Pascual Guàrdia, Sergi, 1979-; Faner, Rosa (European Respiratory Society, 2022)
  • Aspiration risk factors, microbiology, and empiric antibiotics for patients hospitalized with community-acquired pneumonia
    Marin Corral, Judith; Pascual Guàrdia, Sergi, 1979-; Amati, Francesco; Aliberti, Stefano; Masclans Enviz, Joan Ramon; Soni, Nilam J.; Rodríguez, Alejandro; Sibila, Oriol; Sanz, Francisco; Sotgiu, Giovanni; Anzueto, Antonio; Dimakou, Katerina; Petrino, Roberta; van de Garde, Ewoudt; Restrepo, Marcos I.; GLIMP investigators (Elsevier, 2021)
    Background: Aspiration community-acquired pneumonia (ACAP) and community-acquired pneumonia (CAP) in patients with aspiration risk factors (AspRFs) are infections associated with anaerobes, but limited evidence suggests ...
  • Bispectral index in hypercapnic encephalopathy associated with COPD exacerbation: a pilot study
    Chalela Rengifo, Roberto José, 1985-; Gallart Gallego, Lluís; Pascual Guàrdia, Sergi, 1979-; Sancho Muñoz, Antonio; Gea Guiral, Joaquim; Orozco Levi, Mauricio (DOVE Medical Press, 2018)
    Background: Hypercapnic encephalopathy is relatively frequent in severe exacerbations of COPD (ECOPDs), with its intensity usually being evaluated through clinical scales. Bispectral index (BIS) is a relatively new technique, ...
  • Consensus on the Management of the COPD Patient in the COVID-19 Setting: COPD Forum Working Group
    Calle Rubio, Myriam; López-Campos, José Luis; Izquierdo Alonso, José Luis; Martínez Pitarch, Dolores; Iriberri Pascual, Milagros; Alcázar Navarrete, Bernardino; Valle Falcones, Manuel; Avilés Inglés, María Jesús; Cabrera López, Carlos; Álvarez Martínez, Carlos José; Ortega Ruiz, Francisco; Golpe, Rafael; Fuster Gomila, Antònia; Pascual Guàrdia, Sergi, 1979-; Riesco Miranda, Juan Antonio; Peces-Barba, Germán; García-Río, Francisco; Martínez Muñiz, Manuel Ángel; Cosío, Borja G. (Elsevier, 2022)
  • Differences in micro-RNA expression profile between vastus lateralis samples and myotubes in COPD cachexia
    Barreiro Portela, Esther; Sancho Muñoz, Antonio; Puig Vilanova, Ester, 1987-; Salazar Degracia, Anna; Pascual Guàrdia, Sergi, 1979-; Casadevall Fusté, Carme; Gea Guiral, Joaquim (American Physiological Society, 2019)
    Quadriceps muscle weakness and wasting are common comorbidities in chronic obstructive pulmonary disease (COPD). Micro-RNA expression upregulation may favor muscle mass growth and differentiation. We hypothesized that the ...
  • Efficacy of FF/UMEC/VI compared with FF/VI and UMEC/VI in patients with COPD: subgroup analysis of the Spain cohort in IMPACT
    Marín, José María; Mateos, Luis; Roldán, Juan; Echave-Sustaeta, José M.; Pascual Guàrdia, Sergi, 1979-; Pardo, María V.; Velasco, Beatriz; Jones, C. Elaine; Kilbride, Sally; Lipson, David A. (SAGE Publications, 2020)
    Objectives: The IMPACT trial has compared the benefit in the reduction of moderate/severe exacerbations of single inhaler triple therapy (SITT) with fluticasone furoate (FF)/umeclidinium (UMEC)/vilanterol (VI) versus dual ...
  • EGFR and KRAS mutations in the non-tumoral lung. Prognosis in patients with adenocarcinoma
    Chalela Rengifo, Roberto José, 1985-; Bellosillo Paricio, Beatriz; Curull Serrano, Víctor; Longarón Rozalen, Raquel; Pascual Guàrdia, Sergi, 1979-; Badenes Bonet, Diana, 1987-; Arriola Aperribay, Edurne; Sánchez-Font, Albert; Pijuan Andujar, Lara; Gea Guiral, Joaquim (MDPI, 2019)
    Tumor recurrence is frequent and survival rates remain extremely low in lung adenocarcinoma (ADC). We hypothesize that carcinogenic factors will promote loco-regional modifications not only in the future tumor, but throughout ...
  • Hospital admissions and mortality in patients with COPD exacerbations and vertebral body compression fractures
    Pascual Guàrdia, Sergi, 1979-; Badenes Bonet, Diana, 1987-; Martín-Ontiyuelo, Clara; Zuccarino, Flavio; Marín Corral, Judith; Rodríguez, Alejandro; Barreiro Portela, Esther; Gea Guiral, Joaquim (Dove Medical Press, 2017)
    BACKGROUND: Vertebral compression fractures (VCF) are common in COPD patients, with osteoporosis being the main cause. The clinical impact of VCF derives mostly from both pain and chest deformity, which may lead to ventilatory ...
  • Impact of COVID-19 on hospital admissions and healthcare quality indicators in non-COVID patients: a retrospective study of the first COVID-19 year in a university hospital in Spain
    Domingo, Laia; Comas Serrano, Mercè; Jansana Riera, Anna; Louro, Javier; Tizón-Marcos, Helena; Cos, Maria Lourdes; Roquer, Jaume; Chillarón Jordan, Juan José; Cirera Lorenzo, Isabel; Pascual Guàrdia, Sergi, 1979-; Sala, Maria; Castells, Xavier (MDPI, 2022)
    Few studies have assessed the impact of the COVID-19 pandemic on non-COVID diseases and healthcare quality. We aimed to evaluate changes in rates of hospitalisations, complications, in-hospital mortality, and readmissions ...
  • Influence of COPD systemic environment on the myogenic function of muscle precursor cells in vitro
    Casadevall Fusté, Carme; Sancho Muñoz, Antonio; Vicente, Ignacio; Pascual Guàrdia, Sergi, 1979-; Admetlló Papiol, Mireia; Gea Guiral, Joaquim (BioMed Central, 2022)
    Background: Loss of muscle mass and function are well-recognized systemic manifestations of chronic obstructive pulmonary disease (COPD). Acute exacerbations, in turn, significantly contribute to upgrade these systemic ...
  • Metabolic signatures associated with severity in hospitalized COVID-19 patients
    Marín Corral, Judith; Rodríguez-Morató, Jose, 1987-; Gómez-Gómez, Àlex; Pascual Guàrdia, Sergi, 1979-; Muñoz-Bermúdez, Rosana; Salazar Degracia, Anna; Pérez-Terán, Purificación; Restrepo, Marcos I.; Khymenets, Olha, 1974-; Haro, Noemí; Masclans Enviz, Joan Ramon; Pozo Mendoza, Óscar J., 1975- (MDPI, 2021)
    The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association with disease severity is crucial to understand COVID-19 ...
  • Phenotypic characterisation of early COPD: a prospective case-control study
    Cosío, Borja G.; Pascual Guàrdia, Sergi, 1979-; Borràs Santos, Alícia; Gea Guiral, Joaquim; García Aymerich, Judith; Faner, Rosa (European Respiratory Society, 2020)
    The phenotypic characteristics of chronic obstructive pulmonary disease (COPD) in individuals younger than 50 years of age (early COPD) are not well defined. This prospective, multicentre, case-control study sought to ...
  • Relationship between the respiratory microbiome and the severity of airflow limitation, history of exacerbations and circulating eosinophils in COPD patients
    Millares, Laura; Pascual Guàrdia, Sergi, 1979-; Montón, Concepción; García-Nuñez, Marian; Lalmolda, Cristina; Faner, Rosa; Casadevall Fusté, Carme; Setó, Laia; Capilla, Silvia; Moreno, Amàlia; Castro-Acosta, Ady Angélica; Alvarez-Martinez, Carlos José; Sibila, Oriol; Peces-Barba, Germán; Cosio, Borja G.; Agustí, Alvar; Gea Guiral, Joaquim; Monsó, Eduard (BioMed Central, 2019)
    Background: The respiratory microbiome is altered in COPD patients but its relationship with core components of the disease, such as the severity of airflow limitation, the frequency of exacerbations or the circulating ...
  • Structural differences in the diaphragm of patients following controlled vs assisted and spontaneous mechanical ventilation
    Marin Corral, Judith; Dot Jordana, Irene, 1982-; Boguñá, Marián; Cecchini Rosell, Lluís; Zapatero, Ana; Gracia Arnillas, María Pilar; Pascual Guàrdia, Sergi, 1979-; Vilà Vilardell, Clara; Castellví, A.; Pérez-Terán, Purificación; Gea Guiral, Joaquim; Masclans Enviz, Joan Ramon (Springer, 2019)
    Purpose: Ventilator-induced diaphragm dysfunction or damage (VIDD) is highly prevalent in patients under mechanical ventilation (MV), but its analysis is limited by the difficulty of obtaining histological samples. In this ...
  • Telomere length but not mitochondrial DNA copy number is altered in both young and old COPD
    Casas-Recasens, Sandra; Mendoza, Nuria; López-Giraldo, Alejandra; Garcia, Tamara; Cosio, Borja G.; Pascual Guàrdia, Sergi, 1979-; Acosta-Castro, Ady; Borrás Santos, Alícia, 1974-; Gea Guiral, Joaquim; Garrabou, Glòria; Agustí, Alvar; Faner, Rosa (Frontiers, 2021)
    Accelerated ageing is implicated in the pathogenesis of respiratory diseases as chronic obstructive pulmonary disease (COPD), but recent evidence indicates that the COPD can have roots early in life. Here we hypothesise ...
  • The phosphodiesterase-4 inhibitor roflumilast reverts proteolysis in skeletal muscle cells of patients with COPD cachexia
    Barreiro Portela, Esther; Puig Vilanova, Ester, 1987-; Salazar Degracia, Anna; Pascual Guàrdia, Sergi, 1979-; Casadevall Fusté, Carme; Gea Guiral, Joaquim (American Physiological Society, 2018)
    Peripheral muscle weakness and mass loss are characteristic features in severe chronic obstructive pulmonary disease (COPD). We hypothesized that the phosphodiesterase (PDE)-4 inhibitor roflumilast-induced cAMP may ameliorate ...