Browsing by Author "Pardo Lozano, Ricardo"

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  • Clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"): the influence of gender and genetics (CYP2D6, COMT, 5-HTT)
    Pardo Lozano, Ricardo; Farré Albaladejo, Magí; Yubero Lahoz, Samanta, 1985-; O'Mathuna, Brian; Torrens, Marta; Mustata, Cristina; Pérez Mañá, Clara; Langohr, Klaus; Cuyàs, Elisabet; Carbó Banús, Marcel·lí; Torre Fornell, Rafael de la (Public Library of Science (PLoS), 2012)
    The synthetic psychostimulant MDMA (±3,4-methylenedioxymethamphetamine, ecstasy) acts as an indirect serotonin, dopamine, and norepinephrine agonist and as a mechanism-based inhibitor of the cytochrome P-450 2D6 (CYP2D6). ...
  • MDMA, methamphetamine, and CYP2D6 pharmacogenetics: what is clinically relevant?
    Torre Fornell, Rafael de la; Yubero Lahoz, Samanta, 1985-; Pardo Lozano, Ricardo; Farré Albaladejo, Magí (Frontiers, 2012)
    In vitro human studies show that the metabolism of most amphetamine-like psychostimulants is regulated by the polymorphic cytochrome P450 isozyme CYP2D6. Two compounds, methamphetamine and 3,4-methylenedioxymethamphetamine ...