Browsing by Author "Palau González, Vanesa"

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  • ADAM17 inhibition may exert a protective effect on COVID-19
    Palau González, Vanesa; Riera, Marta; Soler, María José (Oxford University Press, 2020)
  • Both specific endothelial and proximal tubular Adam17 deletion protect against diabetic nephropathy
    Palau González, Vanesa; Nugraha, Bramasta; Benito, David; Pascual Santos, Julio; Emmert, Maximilian Y.; Hoerstrup, Simon P.; Riera, Marta; Soler, María José (MDPI, 2021)
    ADAM17 is a disintegrin and metalloproteinase capable of cleaving the ectodomains of a diverse variety of molecules including TNF-α, TGF-α, L-selectin, and ACE2. We have previously demonstrated that renal ADAM17 is upregulated ...
  • Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse
    Roca-Ho, Heleia; Riera Oliva, Marta; Palau González, Vanesa; Pascual Santos, Julio; Soler, María José (MDPI, 2017)
    Renin angiotensin system (RAS) is known to play a key role in several diseases such as diabetes, and renal and cardiovascular pathologies. Its blockade has been demonstrated to delay chronic kidney disease progression and ...
  • Endothelial ADAM17 expression in the progression of kidney injury in an obese mouse model of pre-diabetes
    Palau González, Vanesa; Jarrín, Josué; Villanueva, Sofia; Benito, David; Márquez, Eva; Rodríguez, Eva; Soler, María José; Oliveras, Anna; Gimeno, Javier; Sans Atxer, Laia; Crespo Barrio, Marta; Pascual Santos, Julio; Barrios Barrera, Clara; Riera Oliva, Marta (MDPI, 2021)
    Disintegrin and metalloproteinase domain 17 (ADAM17) activates inflammatory and fibrotic processes through the shedding of various molecules such as Tumor Necrosis Factor-α (TNF-α) or Transforming Growht Factor-α (TGF-α). ...
  • Redefining the role of ADAM17 in renal proximal tubular cells and its implications in an obese mouse model of pre-diabetes
    Palau González, Vanesa; Villanueva, Sofia; Jarrín, Josué; Benito, David; Márquez, Eva; Rodríguez, Eva; Soler, María José; Oliveras, Anna; Gimeno Beltran, Javier; Sans Atxer, Laia; Crespo Barrio, Marta; Pascual Santos, Julio; Barrios Barrera, Clara; Riera Oliva, Marta (MDPI, 2021)
    Acute and chronic kidney lesions induce an increase in A Disintegrin And Metalloproteinase domain 17 (ADAM17) that cleaves several transmembrane proteins related to inflammatory and fibrotic pathways. Our group has ...
  • Role of ADAM17 in kidney disease
    Palau González, Vanesa; Pascual Santos, Julio; Soler, María José; Riera Oliva, Marta (American Physiological Society, 2019)
    It is known that the renin-angiotensin system plays a major role in the pathophysiology of cardiovascular disease and renal injury. Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG ...
  • SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients
    Gutiérrez-Chamorro, Lucía; Riveira Muñoz, Eva; Barrios Barrera, Clara; Palau González, Vanesa; Nevot, Maria; Pedreño-López, Sònia; Senserrich, Jordi; Massanella Luna, Marta, 1983-; Clotet, Bonaventura; Cabrera, Cecilia; Mitjà, Oriol; Crespo Barrio, Marta; Pascual Santos, Julio; Riera, Marta; Ballana Guix, Ester (MDPI, 2021)
    Angiotensin converting enzyme 2 (ACE2) is a host ectopeptidase and the receptor for the SARS-CoV-2 virus, albeit virus-ACE2 interaction goes far beyond viral entry into target cells. Controversial data exists linking viral ...
  • The GenoDiabMar registry: A collaborative research platform of type 2 diabetes patients
    Sierra, Adriana; Otero, Sol; Rodríguez, Eva; Faura, Anna; Vera, María; Riera, Marta; Palau González, Vanesa; Duran Jordà, Xavier, 1974-; Costa-Garrido, Anna; Sans Atxer, Laia; Márquez, Eva; Poposki, Vladimir; Franch-Nadal, Josep; Mundet-Tudurí, Xavier; Oliveras, Anna; Crespo Barrio, Marta; Pascual Santos, Julio; Barrios Barrera, Clara (MDPI, 2022)
    The GenoDiabMar registry is a prospective study that aims to provide data on demographic, biochemical, and clinical changes in type 2 diabetic (T2D) patients attending real medical outpatient consultations. This registry ...