Browsing by Author "Pagès Pinós, Amadís"

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  • A chromatin code for alternative splicing involving a putative association between CTCF and HP1alpha proteins
    Agirre Ortiz de Guzmán, Eneritz, 1983-; Bellora Pereyra, Nicolás; Alló, Mariano; Pagès Pinós, Amadís; Bertucci, Paola; Kornblihtt, Alberto R.; Eyras Jiménez, Eduardo (BioMed Central, 2015)
    BACKGROUND: Alternative splicing is primarily controlled by the activity of splicing factors and by the elongation of the RNA polymerase II (RNAPII). Recent experiments have suggested a new complex network of splicing ...
  • A semi-supervised approach uncovers thousands of intragenic enhancers differentially activated in human cells
    González-Vallinas Rostes, Juan, 1983-; Pagès Pinós, Amadís; Singh, Babita, 1986-; Eyras Jiménez, Eduardo (BioMed Central, 2015)
    Background. Transcriptional enhancers are generally known to regulate gene transcription from afar. Their activation involves a series of changes in chromatin marks and recruitment of protein factors. These enhancers may ...
  • Computational tools for the study of RNA processing and function
    Pagès Pinós, Amadís (Universitat Pompeu Fabra, 2018-06-26)
    El processament de les cadenes d’àcids ribonucleics (ARN) és un mecanisme mol·lecular crucial gràcies al qual els precursors delsARN missatgers es converteixen en ARN missatgers madurs. L’exemple més notable és l’anomenat ...
  • Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks
    Sebestyén, Endre; Singh, Babita, 1986-; Miñana Gómez, Belén; Pagès Pinós, Amadís; Mateo, Francesc; Pujana, Miguel Angel; Valcárcel, J. (Juan); Eyras Jiménez, Eduardo (Cold Spring Harbor Laboratory Press (CSHL Press), 2016)
    Alternative splicing is regulated by multiple RNA-binding proteins and influences the expression of most eukaryotic genes. However, the role of this process in human disease, and particularly in cancer, is only starting ...
  • Leveraging transcript quantification for fast computation of alternative splicing profiles
    Alamancos, Gael P.; Pagès Pinós, Amadís; Trincado Alonso, Juan Luis, 1987-; Bellora Pereyra, Nicolás; Eyras Jiménez, Eduardo (Cambridge University Press, 2015)
    Alternative splicing plays an essential role in many cellular processes and bears major relevance in the understanding of multiple diseases, including cancer. High-throughput RNA sequencing allows genome-wide analyses of ...
  • Predictive models of gene regulation from high-throughput epigenomics data
    Althammer, Sonja Daniela; Pagès Pinós, Amadís; Eyras Jiménez, Eduardo (Hindawi, 2012)
    The epigenetic regulation of gene expression involves multiple factors. The synergistic or antagonistic action of these factors has suggested the existence of an epigenetic code for gene regulation. Highthroughput sequencing ...
  • The 5' untranslated region of the serotonin receptor 2C pre-mRNA generates miRNAs and is expressed in non-neuronal cells
    Zhang, Zhaiyi; Falaleeva, Marina; Agranat-Tamir, Lily; Pagès Pinós, Amadís; Eyras Jiménez, Eduardo; Sperling, Joseph; Sperling, Ruth; Stamm, Stefan (Springer Verlag, 2013)
    The serotonin receptor 2C (HTR2C) gene encodes a G protein-coupled receptor that is exclusively expressed in neurons. Here, we report that the 5' untranslated region of the receptor pre-mRNA as well as its hosted miRNAs ...
  • The discovery potential of RNA processing profiles
    Pagès Pinós, Amadís; Dotu, Ivan; Pallarès Albanell, Joan; Martí Puig, Eulàlia; Guigó Serra, Roderic; Eyras Jiménez, Eduardo (Oxford University Press, 2018)
    Small non-coding RNAs (sncRNAs) are highly abundant molecules that regulate essential cellular processes and are classified according to sequence and structure. Here we argue that read profiles from size-selected RNA ...
  • The prognostic potential of alternative transcript isoforms across human tumors
    Trincado Alonso, Juan Luis, 1987-; Sebestyén, Endre; Pagès Pinós, Amadís; Eyras Jiménez, Eduardo (BioMed Central, 2016)
    Background: Phenotypic changes during cancer progression are associated with alterations in gene expression, which can be exploited to build molecular signatures for tumor stage identification and prognosis. However, it ...

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