Browsing by Author "PRACTICAL Consortium"

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  • Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan
    Hollis, Ben; Day, Felix R.; Busch, Alexander S.; Thompson, Deborah J.; Soares, Ana Luiza G.; Timmers, Paul R.H.J.; Kwong, Alex; Easton, Doug F.; Joshi, Peter K.; Timpson, Nicholas J.; PRACTICAL Consortium; 23andMe Research Team; Ong, Ken K.; Perry, John R. B. (Nature Research, 2020)
    The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait ...
  • Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
    Huynh-Le, Minh Phuong; Kogevinas, Manolis; PRACTICAL Consortium (Nature Research, 2021)
    Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and ...