Browsing by Author "Pérez Vilaró, Gemma, 1985-"

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  • CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome
    Jungfleisch, Jennifer, 1986-; Böttcher, René; Talló Parra, Marc, 1992-; Pérez Vilaró, Gemma, 1985-; Merits, Andres; Novoa, Eva Maria; Díez Antón, Juana, 1962- (Nature Research, 2022)
    Ample evidence indicates that codon usage bias regulates gene expression. How viruses, such as the emerging mosquito-borne Chikungunya virus (CHIKV), express their genomes at high levels despite an enrichment in rare codons ...
  • Hepatitis C virus infection inhibits P-body granule formation in human livers
    Pérez Vilaró, Gemma, 1985-; Fernández-Carrillo, Carlos; Mensa, Laura; Miquel, Rosa; Sanjuan, Xavier; Forns, Xavier; Pérez del Pulgar, Sofía; Díez Antón, Juana, 1962- (Elsevier, 2015)
    BACKGROUND & AIMS: Decoding the myriad of interactions that hepatitis C virus (HCV) establishes with infected cells is mandatory to obtain a complete understanding of HCV biology and its associated pathogenesis. We and ...
  • Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells
    Chen, Tzu-Chun; Talló Parra, Marc, 1992-; Cao, Qian M.; Kadener, Sebastian; Böttcher, René; Pérez Vilaró, Gemma, 1985-; Boonchuen, Pakpoom; Somboonwiwat, Kunlaya; Díez Antón, Juana, 1962-; Sarnow, Peter (Public Library of Science (PLoS), 2020)
    Viruses subvert macromolecular pathways in infected host cells to aid in viral gene amplification or to counteract innate immune responses. Roles for host-encoded, noncoding RNAs, including microRNAs, have been found to ...
  • Low zinc levels at admission associates with poor clinical outcomes in SARS-CoV-2 infection
    Vogel-González, Marina; Talló Parra, Marc, 1992-; Herrera-Fernández, Víctor; Pérez Vilaró, Gemma, 1985-; Chillón, Miguel; Nogués Solan, Francesc Xavier; Gómez-Zorrilla, Silvia; López Montesinos, Inmaculada; Arnau-Barrés, Isabel; Sorli Redó, M. Luisa; Horcajada Gallego, Juan Pablo; García-Giralt, Natalia; Pascual Santos, Julio; Díez Antón, Juana, 1962-; Vicente García, Rubén, 1978-; Güerri Fernández, Roberto (MDPI, 2021)
    Background: Zinc is an essential micronutrient that impacts host-pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc ...
  • Oligonucleotide-lipid conjugates forming G-quadruplex structures are potent and pangenotypic hepatitis C virus entry inhibitors in vitro and ex vivo
    Koutsoudakis, George; Paris de León, Alexia; Herrera, Carolina; Dorner, Marcus; Pérez Vilaró, Gemma, 1985-; Lyonnais, Sébastien; Grijalvo, Santiago; Eritja, Ramon; Meyerhans, Andreas; Mirambeau, Gilles; Díez Antón, Juana, 1962- (American Society for Microbiology, 2017)
    A hepatitis C virus (HCV) epidemic affecting HIV-infected men who have sex with men (MSM) is expanding worldwide. In spite of the improved cure rates obtained with the new direct-acting antiviral drug (DAA) combinations, ...
  • Pan-genotypic hepatitis C virus inhibition by natural products derived from the wild Egyptian artichoke
    Elsebai, Mahmoud Fahmi; Koutsoudakis, George; Saludes, Verónica; Pérez Vilaró, Gemma, 1985-; Turpeinen, Ari; Mattila, Sampo; Pirttilä, Anna Maria; Fontaine, Fabien; Mehiri, Mohamed; Meyerhans, Andreas; Díez Antón, Juana, 1962- (American Society for Microbiology, 2016)
    Hepatitis C virus (HCV) infection is the leading cause of chronic liver diseases. Water extracts of the leaves of the wild Egyptian artichoke (WEA) [Cynara cardunculus L. var. sylvestris (Lam.) Fiori] have been used for ...
  • Soraphen A: a broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity
    Koutsoudakis, George; Romero-Brey, Inés; Berger, Carola; Pérez Vilaró, Gemma, 1985-; Monteiro Perin, Paula; Vondran, Florian Wolfgang Rudolf; Kalesse, Markus; Harmrolfs, Kirsten; Müller, Rolf; Martínez, Javier P.; Pietschmann, Thomas; Bartenschlager, Ralf; Brönstrup, Mark; Meyerhans, Andreas; Díez Antón, Juana, 1962- (Elsevier, 2015)
    BACKGROUND & AIMS: Soraphen A (SorA) is a myxobacterial metabolite that inhibits the acetyl-CoA carboxylase, a key enzyme in lipid biosynthesis. We have previously identified SorA to efficiently inhibit the human ...
  • Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity
    Doñate-Macián, Pau; Duarte, Yorley; Rubio Moscardo, Fanny; Pérez Vilaró, Gemma, 1985-; Canan, Jonathan; Díez Antón, Juana, 1962-; González Nilo, Fernando; Valverde, M. A. (Miguel Ángel), 1963- (Wiley, 2022)
    Background and purpose: The transient receptor potential vanilloid 4 (TRPV4) cation channel participates in multiple physiological processes and is also at the core of different diseases, making this channel an interesting ...
  • The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity
    Doñate-Macián, Pau; Jungfleisch, Jennifer, 1986-; Pérez Vilaró, Gemma, 1985-; Rubio Moscardó, Fanny; Perálvarez Marín, Alex; Díez Antón, Juana, 1962-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2018)
    Ion channels are well placed to transduce environmental cues into signals used by cells to generate a wide range of responses, but little is known about their role in the regulation of RNA metabolism. Here we show that the ...

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