Browsing by Author "Pérez Ortín, José E."

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  • Comparison of Xrn1 and Rat1 5' → 3' exoribonucleases in budding yeast supports the specific role of Xrn1 in cotranslational mRNA decay
    Pérez Ortín, José E.; Jordán Pla, Antonio; Zang, Yujie; Moreno García, Jorge; Bassot, Claudio; Barba Aliaga, Marina; Campos Mata, Leire de, 1991-; Choder, Mordechai; Díez Antón, Juana, 1962-; Piazza, Ilaria; Pelechano, Vicent; García Martínez, José (Wiley, 2024)
    The yeast Saccharomyces cerevisiae and most eukaryotes carry two 5' → 3' exoribonuclease paralogs. In yeast, they are called Xrn1, which shuttles between the nucleus and the cytoplasm, and executes major cytoplasmic messenger ...
  • The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins
    Blasco-Moreno, Bernat; de Campos-Mata, Leire; Böttcher, René; García Martínez, José; Jungfleisch, Jennifer, 1986-; Nedialkova, Danny D.; Chattopadhyay, Shiladitya; Gas, María-Eugenia; Oliva Miguel, Baldomero; Pérez Ortín, José E.; Leidel, Sebastian; Choder, Mordechai; Díez Antón, Juana, 1962- (Nature Research, 2019)
    The highly conserved 5’–3’ exonuclease Xrn1 regulates gene expression in eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay. By integrating transcriptome-wide analyses of translation with biochemical ...
  • Topoisomerase II regulates yeast genes with singular chromatin architectures
    Nikolaou, Christoforos; Bermúdez, Ignacio; Manichanh, Chaysavanh; García Martínez, José; Guigó Serra, Roderic; Pérez Ortín, José E.; Roca, Joaquim (Oxford University Press, 2013)
    Eukaryotic topoisomerase II (topo II) is the essential decatenase of newly replicated chromosomes and the main relaxase of nucleosomal DNA. Apart from these general tasks, topo II participates in more specialized functions. ...

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