Browsing by Author "Pérez Mañá, Clara"

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  • A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure
    Poyatos, Lourdes; Papaseit Fontanet, Esther; Olesti Muñoz, Eulàlia, 1991-; Pérez Mañá, Clara; Ventura, Mireia; Carbón Mallol, Xoán; Grifell Guardia, Marc; Fonseca Casals, Francina, 1972-; Torrens, Marta; Torre Fornell, Rafael de la; Farré Albaladejo, Magí (MDPI, 2021)
    Considered the β-keto analogue of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), 3,4-Methylenedioxymethcathinone (methylone) is a synthetic cathinone. Over the years, methylone has been used as a substitute for ...
  • Abuse potential of cathinones in humans: a systematic review
    Poyatos, Lourdes; Torres, Adrián; Papaseit Fontanet, Esther; Pérez Mañá, Clara; Hladun, Olga; Núñez-Montero, Melani; de la Rosa, Georgina; Torrens, Marta; Fuster, Daniel; Muga, Roberto; Farré Albaladejo, Magí (MDPI, 2022)
    Introduction and objective: assessing the abuse potential of new substances with central nervous system activity is essential for preventing possible risks of misuse and addiction. The same methodology is recommended for ...
  • Acute effects of 2C-E in humans: an observational study
    Papaseit Fontanet, Esther; Olesti Muñoz, Eulàlia, 1991-; Pérez Mañá, Clara; Torrens, Marta; Grifell Guardia, Marc; Ventura, Mireia; Pozo Mendoza, Óscar J., 1975-; de Sousa Fernandes Perna, Elizabeth B.; Ramaekers, Johannes G.; Torre Fornell, Rafael de la; Farré Albaladejo, Magí (Frontiers, 2020)
    2,5-Dimethoxy-4-ethylphenethylamine (2C-E) is psychedelic phenylethylamine, with a chemical structure similar to mescaline, used as new psychoactive substance (NPS). It inhibits norepinephrine and serotonin uptake and, ...
  • Acute pharmacological effects of 2C-B in humans: An observational study
    Papaseit Fontanet, Esther; Farré Albaladejo, Magí; Pérez Mañá, Clara; Torrens, Marta; Ventura, Mireia; Pujadas, Mitona; Torre Fornell, Rafael de la; González, Débora (Frontiers, 2018)
    2,5-dimethoxy-4-bromophenethylamine (2C-B) is a psychedelic phenylethylamine derivative, structurally similar to mescaline. It is a serotonin 5-hydroxytryptamine-2A (5-HT2A), 5-hydroxytryptamine-2B (5-HT2B), and ...
  • Acute pharmacological effects of oral and intranasal mephedrone: an observational study in humans
    Papaseit Fontanet, Esther; Olesti Muñoz, Eulàlia, 1991-; Pérez Mañá, Clara; Torrens, Marta; Fonseca Casals, Francina, 1972-; Grifell Guardia, Marc; Ventura, Mireia; Torre Fornell, Rafael de la; Farré Albaladejo, Magí (MDPI, 2021)
    Mephedrone (4-methylmethcathinone) is a synthetic cathinone with psychostimulant properties which remains one of the most popular new psychoactive substances (NPS). It is frequently used orally and/or intranasally. To date, ...
  • Additional studies on triamcinolone acetonide use and misuse in sports: elimination profile after intranasal and high-dose intramuscular administrations
    Coll Camenforte, Sergi, 1991-; Monfort Mercader, Núria, 1983-; Alechaga, Élida; Matabosch Geronès, Xavier; Pérez Mañá, Clara; Ventura Alemany, Rosa (Elsevier, 2019)
    Triamcinolone acetonide (TA) is a glucocorticoid (GC) widely used in sports medicine. GCs are prohibited in sports competitions by oral, intramuscular (IM), intravenous and rectal administrations, and they are allowed by ...
  • Analysis of free hydroxytyrosol in human plasma following the administration of olive oil.
    Pastor, Antonio; Rodríguez-Morató, Jose, 1987-; Olesti Muñoz, Eulàlia, 1991-; Pujadas Bastardes, Mitona; Pérez Mañá, Clara; Khymenets, Olha, 1974-; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Solà, Rosa; Motilva, Maria-José; Farré Albaladejo, Magí; Torre Fornell, Rafael de la (Elsevier, 2016)
    Hydroxytyrosol (HT) from olive oil, a potent bioactive molecule with health benefits, has a poor bioavailability, its free form (free HT) being undetectable so far. This fact leads to the controversy whether attained HT ...
  • Antidepressant drugs and COVID-19: A review of basic and clinical evidence
    Mas, Marta; García-Vicente, Juan Antonio; Estrada-Gelonch, Anaïs; Pérez Mañá, Clara; Papaseit Fontanet, Esther; Torrens, Marta; Farré Albaladejo, Magí (MDPI, 2022)
    The COVID-19 pandemic has encouraged the repurposing of existing drugs as a shorter development strategy in order to support clinicians with this difficult therapeutic dilemma. There is evidence to support the theory that ...
  • BDNF and cortisol in the diagnosis of cocaine-induced depression
    Fonseca Casals, Francina, 1972-; Mestre-Pintó, Juan Ignacio; Rodríguez-Minguela, Rocío; Papaseit Fontanet, Esther; Pérez Mañá, Clara; Langohr, Klaus; Barbuti, Margherita; Farré Albaladejo, Magí; Torrens, Marta; Neurodep Group (Frontiers, 2022)
    Background: Major depressive disorder (MDD) and cocaine use disorder (CUD) are related with disability and high mortality rates. The assessment and treatment of psychiatric comorbidity is challenging due to its high ...
  • Budesonide use and misuse in sports: elimination profiles of budesonide and metabolites after intranasal, high-dose inhaled and oral administrations
    Coll Camenforte, Sergi, 1991-; Monfort Mercader, Núria, 1983-; Matabosch Geronès, Xavier; Papakonstantinou, Katerina; Pérez Mañá, Clara; Mateus Rodriguez, Julian Andrés; Ventura Alemany, Rosa (Wiley, 2020)
    Budesonide (BUD) is a glucocorticoid (GC) widely used in therapeutics. In sports, the World Anti-doping Agency (WADA) controls the use of GCs, and WADA-accredited laboratories use a reporting level of 30 ng/mL for ...
  • Cannabinoids: from pot to lab
    Papaseit Fontanet, Esther; Pérez Mañá, Clara; Pérez-Acevedo, Ana Pilar; Hladun, Olga; Torres-Moreno, Mari Carmen; Muga, Roberto; Torrens, Marta; Farré Albaladejo, Magí (Ivyspring International Publisher, 2018)
    Cannabis is becoming increasingly present in our society. In recent years, the line between the natural (cannabis) and the synthetic (synthetic cannabinoids), the recreational (cannabis) and the medical (pharmaceutical ...
  • Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans: a randomized, controlled trial
    Boronat Rigol, Anna, 1990-; Mateus Rodriguez, Julian Andrés; Soldevila-Domenech, Natalia; Guerra, Mercè; Rodríguez-Morató, Jose, 1987-; Varon, Carlota; Muñoz Aguayo, Daniel; Barbosa, Francina; Morales, Juan Carlos; Gaedigk, Andreas; Langohr, Klaus; Covas Planells, Maria Isabel; Pérez Mañá, Clara; Fitó Colomer, Montserrat; Tyndale, Rachel F.; Torre Fornell, Rafael de la (Elsevier, 2019)
    Introduction: The simple phenol hydroxytyrosol (OHTyr) has been associated with the beneficial health effects of extra virgin olive oil. Pre-clinical studies have identified Tyr hydroxylation, mediated by cytochrome P450 ...
  • Clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"): the influence of gender and genetics (CYP2D6, COMT, 5-HTT)
    Pardo Lozano, Ricardo; Farré Albaladejo, Magí; Yubero Lahoz, Samanta, 1985-; O'Mathuna, Brian; Torrens, Marta; Mustata, Cristina; Pérez Mañá, Clara; Langohr, Klaus; Cuyàs, Elisabet; Carbó Banús, Marcel·lí; Torre Fornell, Rafael de la (Public Library of Science (PLoS), 2012)
    The synthetic psychostimulant MDMA (±3,4-methylenedioxymethamphetamine, ecstasy) acts as an indirect serotonin, dopamine, and norepinephrine agonist and as a mechanism-based inhibitor of the cytochrome P-450 2D6 (CYP2D6). ...
  • CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol.
    Rodríguez-Morató, Jose, 1987-; Robledo, Patricia, 1958-; Tanner, Julie-Anne; Boronat Rigol, Anna, 1990-; Pérez Mañá, Clara; Oliver Chen, CY; Tyndale, Rachel F.; Torre Fornell, Rafael de la (Elsevier, 2016)
    The dietary phenol tyrosol has been reported to be endogenously transformed into hydroxytyrosol, a potent antioxidant with multiple health benefits. In this work, we evaluated whether tyrosine hydroxylase (TH) and cytochrome ...
  • Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans
    Boronat Rigol, Anna, 1990-; Mateus Rodriguez, Julian Andrés; Soldevila-Domenech, Natalia; Guerra Albà, Mercè; Rodríguez-Morató, Jose, 1987-; Varon, Carlota; Muñoz, Daniel; Barbosa, Francina; Morales, Juan Carlos; Gaedigk, Andreas; Langohr, Klaus; Covas Planells, Maria Isabel; Pérez Mañá, Clara; Fitó Colomer, Montserrat; Tyndale, Rachel F.; Torre Fornell, Rafael de la (Elsevier, 2019)
    Here we present new and original data on the endogenous conversion of tyrosol (Tyr) into hydroxytyrosol (OHTyr) in humans and its effects on the cardiovascular system. A randomized, crossover, controlled clinical trial was ...
  • Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS.
    Matabosch Geronès, Xavier; Pozo Mendoza, Óscar J., 1975-; Pérez Mañá, Clara; Papaseit Fontanet, Esther; Segura Noguera, Jordi; Ventura Alemany, Rosa (Wiley, 2015)
    Glucocorticosteroids are prohibited in sports when used by systemic administrations (e.g. oral), whereas they are allowed using other administration ways. Strategies to discriminate between administrations routes have to ...
  • Detection of growth hormone releasing peptides in serum by a Competitive receptor binding assay
    Ferro, P.; Krotov, G.; Zvereva, I.; Pérez Mañá, Clara; Mateus Rodriguez, Julian Andrés; Segura, Joan (Elsevier, 2017)
    The use of small peptides for medical purposes has gained great importance in the last decade. Among these molecules are the growth hormone releasing peptides (GHRPs). These substances are highly sought by cheating athletes ...
  • Dose-response pharmacological study of mephedrone and its metabolites: pharmacokinetics, serotoninergic effects, and impact of CYP2D6 genetic variation
    Olesti Muñoz, Eulàlia, 1991-; Farré Albaladejo, Magí; Carbó Banús, Marcel·lí; Papaseit Fontanet, Esther; Pérez Mañá, Clara; Torrens, Marta; Yubero Lahoz, Samanta, 1985-; Pujadas Bastardes, Mitona; Pozo Mendoza, Óscar J., 1975-; Torre Fornell, Rafael de la (Wiley, 2019)
    Mephedrone (MEPH), the most widely consumed synthetic cathinone, has been associated with acute toxicity episodes. The aim of this report was to study its metabolic disposition and the impact of genetic variation of CYP2D6 ...
  • Drug Interactions With New Synthetic Opioids
    Pérez Mañá, Clara; Papaseit Fontanet, Esther; Fonseca Casals, Francina, 1972-; Farré Martínez, Adriana; Torrens, Marta; Farré Albaladejo, Magí (Frontiers, 2018)
    Fentanyl, fentanyl analogs, and other new synthetic opioids (NSO) have burst onto the illegal drug market as new psychoactive substances (NPS). They are often sold as heroin to unsuspecting users and produce euphoria through ...
  • Effects of mixing energy drinks with alcohol on driving-related skills
    Pérez Mañá, Clara; Mateus Rodriguez, Julian Andrés; Díaz-Pellicer, Patricia; Díaz-Baggerman, Ariadna; Pérez, Marta; Pujadas Bastardes, Mitona; Fonseca Casals, Francina, 1972-; Papaseit Fontanet, Esther; Pujol, Jesús; Langohr, Klaus; Torre Fornell, Rafael de la (Oxford University Press, 2022)
    Background: Energy drinks (EDs) reduce sleepiness and fatigue and improve driving performance whereas alcohol does just the opposite. Although it is a trendy combination among young people, the effects of alcohol mixed ...

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