Browsing by Author "Orozco, Modesto"

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  • Vidal Ocabo, Enrique; Sayols, Sergi; Moran, Sebastian; Guillaumet-Adkins, Amy; Schroeder, Michael Philipp, 1986-; Royo, Romina; Orozco, Modesto; Gut, Marta; Gut, Ivo Glynne; López Bigas, Núria; Heyn, Holger; Esteller, Manel (Nature Publishing Group, 2017)
    Although single base-pair resolution DNA methylation landscapes for embryonic and different somatic cell types provided important insights into epigenetic dynamics and cell-type specificity, such comprehensive profiling ...
  • Escobedo, Albert; Piccirillo, Jonathan; Aranda, Juan; Diercks, Tammo; Mateos, Borja; Garcia-Cabau, Carla; Sánchez-Navarro, Macarena; Topal, Busra; Biesaga, Mateusz; Staby, Lasse; Kragelund, Birthe B.; García, Jesús; Millet, Oscar; Orozco, Modesto; Coles, Murray; Crehuet, Ramon; Salvatella, Xavier (Nature Research, 2022)
    The binding of intrinsically disordered proteins to globular ones can require the folding of motifs into α-helices. These interactions offer opportunities for therapeutic intervention but their modulation with small molecules ...
  • Kuzmanic, Antonija; Sutto, Ludovico; Saladino, Giorgio; Nebreda, Ángel R.; Gervasio, Francesco L.; Orozco, Modesto (eLife, 2017)
    p38α is a Ser/Thr protein kinase involved in a variety of cellular processes and pathological conditions, which makes it a promising pharmacological target. Although the activity of the enzyme is highly regulated, its ...
  • Porrini, Massimiliano; Rosu, Frédéric; Rabin, Clémence; Darré, Leonardo; Gómez, Hansel; Orozco, Modesto; Gabelica, Valérie (American Chemical Society (ACS), 2017)
    We report on the fate of nucleic acids conformation in the gas phase as sampled using native mass spectrometry coupled to ion mobility spectrometry. On the basis of several successful reports for proteins and their complexes, ...
  • Espinosa Angarica, Vladimir; Orozco, Modesto; Sancho, Javier (Oxford University Press, 2016)
    Familial hypercholesterolemia (FH), a genetic disorder with a prevalence of 0.2%, represents a high-risk factor to develop cardiovascular and cerebrovascular diseases. The majority and most severe FH cases are associated ...
  • Buitrago, Diana; Labrador, Mireia; Arcon, Juan Pablo; Lema, Rafael; Flores, Oscar; Esteve-Codina, Anna; Blanc, Julie; Villegas, Núria; Bellido, David; Gut, Marta; Dans, Pablo D.; Heath, Simon; Gut, Ivo Glynne; Brun-Heath, Isabelle; Orozco, Modesto (Nature Research, 2021)
    Determining the effect of DNA methylation on chromatin structure and function in higher organisms is challenging due to the extreme complexity of epigenetic regulation. We studied a simpler model system, budding yeast, ...
  • Deniz, Özgen; Flores, Oscar; Aldea, Martí; Soler López, Montserrat; Orozco, Modesto (Nature Publishing Group, 2016)
    Nucleosomes provide additional regulatory mechanisms to transcription and DNA replication by mediating the access of proteins to DNA. During the cell cycle chromatin undergoes several conformational changes, however the ...
  • Buitrago, Diana; Codó, Laia; Illa, Ricard; Jorge, Pau de; Battistini, Federica; Flores, Oscar; Bayarri, Genis; Royo, Romina; Pino, Marc del; Heath, Simon; Hospital, Adam; Gelpí, Josep Lluís; Brun-Heath, Isabelle; Orozco, Modesto (Oxford University Press, 2019)
    We present Nucleosome Dynamics, a suite of programs integrated into a virtual research environment and created to define nucleosome architecture and dynamics from noisy experimental data. The package allows both the ...
  • López Ferrando, Víctor; Gazzo, Andrea M.; Cruz, Xavier de la; Orozco, Modesto; Gelpí, Josep Lluís (Oxford University Press, 2017)
    We present here a full update of the PMut predictor, active since 2005 and with a large acceptance in the field of predicting Mendelian pathological mutations. PMut internal engine has been renewed, and converted into a ...
  • Saint-Léger, Adélaïde; Bello, Carla, 1990-; Dans, Pablo D.; Gabriel Torres, Adrian; Novoa, Eva Maria; Camacho, Noelia; Orozco, Modesto; Kondrashov, Fyodor A., 1979-; Ribas de Pouplana, Lluís (American Association for the Advancement of Science (AAAS), 2016)
    Understanding the principles that led to the current complexity of the genetic code is a central question in evolution. Expansion of the genetic code required the selection of new transfer RNAs (tRNAs) with specific ...
  • Durán, Elisa; Djebali, Sarah; González, Santi; Flores, Oscar; Mercader Bigas, Josep Maria; Guigó Serra, Roderic; Torrents, David; Soler López, Montserrat; Orozco, Modesto (Oxford University Press, 2013)
    Although protein recognition of DNA motifs in promoter regions has been traditionally considered as a critical regulatory element in transcription, the location of promoters, and in particular transcription start sites ...

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