Browsing by Author "Opazo, Carlos M."

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  • Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons
    Castro, Patricio A.; Ramírez, Alejandra E.; Sepúlveda, Fernando J.; Peters, Christian; Fierro, Humberto; Waldron, Javier; Luza, Sandra; Fuentealba, Jorge; Muñoz López, Francisco José, 1964-; De Ferrari, Giancarlo V.; Bush, Ashley I.; Aguayo, Luis G.; Opazo, Carlos M. (Frontiers, 2014)
    Extracellular and intracellular copper and zinc regulate synaptic activity and plasticity, which may impact brain functionality and human behavior. We have found that a metal coordinating molecule, Neocuproine, transiently ...
  • Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane
    Pacheco, Carla R.; Morales, Camila N.; Ramírez, Alejandra E.; Muñoz López, Francisco José, 1964-; Gallegos, Scarlet S.; Caviedes, Pablo A.; Aguayo, Luis G.; Opazo, Carlos M. (Wiley, 2015)
    It has been postulated that the accumulation of extracellular α-synuclein (α-syn) might alter the neuronal membrane by formation of 'pore-like structures' that will lead to alterations in ionic homeostasis. However, this ...
  • Nitro-oxidative stress after neuronal ischemia induces protein nitrotyrosination and cell death
    Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Palomer, Ernest; Ramos Fernández, Eva, 1984-; Guix Ràfols, Francesc Xavier; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Jiménez Conde, Jordi; Ois Santiago, Angel Javier; Pérez Asensio, Fernando; Reyes Navarro, Mario; Caballo, Carolina; Galán, Ana M.; Alameda Quitllet, Francisco; Escolar, Ginès; Opazo, Carlos M.; Planas, Anna; Roquer, Jaume; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Hindawi, 2013)
    Ischemic stroke is an acute vascular event that obstructs blood supply to the brain, producing irreversible damage that affects neurons but also glial and brain vessel cells. Immediately after the stroke, the ischemic ...
  • Stable complexes involving acetylcholinesterase and amyloid-ß-peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils
    Álvarez, Alejandra R.; Alarcón Martínez, Rodrigo; Opazo, Carlos M.; Campos, Eliseo O.; Muñoz López, Francisco José, 1964-; Calderón, Frances H.; Dajas, Federico; Gentry, Mary K.; Doctor, Bhupendra P.; Mello, Fernando G. de; Inestrosa, Nibaldo C. (Society for Neuroscience, 1998)
    Brain acetylcholinesterase (AChE) forms stable complexes with amyloid-beta peptide (Abeta) during its assembly into filaments, in agreement with its colocalization with the Abeta deposits of Alzheimer's brain. The association ...
  • The pathophysiology of axonal transport in alzheimer’s disease
    Vicario Orri, Elena, 1989-; Opazo, Carlos M.; Muñoz López, Francisco José, 1964- (IOS Press, 2015)
    Neurons communicate in the nervous system by carrying out information along the length of their axons to finally transmit it at the synapse. Proper function of axons and axon terminals relies on the transport of proteins, ...
  • Vitamin E but not 17B-estradiol protect against vascular toxicity induced by B-amyloid wild type and the Dutch amyploid variant
    Muñoz López, Francisco José, 1964-; Opazo, Carlos M.; Gil Gómez, Gabriel; Tapia, Gladys; Fernández, Virginia; Valverde, M. A. (Miguel Ángel), 1963-; Inestrosa, Nibaldo C. (Society for Neuroscience, 2002)
    Amyloid β-peptide (Aβ) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients. An early onset of a cerebral amyloid angiopathy variant called ...