Browsing by Author "Nogués Solan, Francesc Xavier"

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  • Assessment of early therapy discontinuation and health-related quality of life in breast cancer patients treated with aromatase inhibitors: B-ABLE cohort study
    Pineda-Moncusí, Marta; Servitja Tormo, Sonia; Tusquets Trias de Bes, Ignacio; Díez Pérez, Adolfo; Rial, Abora; Cos, Maria Lourdes; Campodarve, Isabel; Rodriguez-Morera, Jaime; Garcia Giralt, Natàlia; Nogués Solan, Francesc Xavier (Springer, 2019)
    PURPOSE: The most frequent adverse effects of aromatase inhibitors (AI) are arthralgia and bone loss induction. These reduce the quality of life of patients and their adherence to the treatment. This study evaluates the ...
  • Bone health evaluation one year after aromatase inhibitors completion
    Pineda-Moncusí, Marta; Servitja Tormo, Sonia; Casamayor, Guillem; Cos, Maria Lourdes; Rial, Abora; Rodriguez-Morera, Jaime; Tusquets Trias de Bes, Ignacio; Díez Pérez, Adolfo; Garcia Giralt, Natàlia; Nogués Solan, Francesc Xavier (Elsevier, 2018)
    Breast cancer patients treated with aromatase inhibitors (AIs) experience increased bone loss during their treatment. However, there is little information about bone mineral density (BMD) after completing AI-treatment. The ...
  • Bone loss induced by cancer treatments in breast and prostate cancer patients
    Castañeda, Santos; Casas, Ana; González-Del-Alba, Aránzazu; Martínez-Díaz-Guerra, Guillermo; Nogués Solan, Francesc Xavier; Ojeda Thies, Cristina; Torregrosa Suau, Óscar; Rodríguez-Lescure, Álvaro (SpringerOpen, 2022)
    Cancer and cancer therapies are a major factor risk for osteoporosis due to bone loss and deterioration of bone microarchitecture. Both factors contribute to a decrease in bone strength and, consequently, increased bone ...
  • Calcifediol treatment and COVID-19-related outcomes
    Nogués Solan, Francesc Xavier; Ovejero Crespo, Diana; Pineda-Moncusí, Marta; Bouillon, Roger; Arenas Jiménez, María Dolores; Pascual Santos, Julio; Ribes, Anna; Guerri-Fernandez, Robert; Villar García, Judit; Rial, Abora; Gimenez-Argente, Carme; Cos, Maria Lourdes; Rodriguez-Morera, Jaime; Campodarve, Isabel; Quesada-Gómez, J.M.; García-Giralt, Natalia (Oxford University Press, 2021)
    Context: COVID-19 is a major health problem because of saturation of intensive care units (ICU) and mortality. Vitamin D has emerged as a potential treatment able to reduce the disease severity. Objective: This work aims ...
  • Circulating microRNA profiling is altered in the acute respiratory distress syndrome related to SARS-CoV-2 infection
    Garcia Giralt, Natàlia; Du, Juan; Marin Corral, Judith; Bódalo-Torruella, Marta; Blasco-Hernando, Fabiola; Muñoz-Bermúdez, Rosana; Clarós, Miquel; Nonell Mazelon, Lara, 1972-; Perera Bel, Júlia; Fernández-González, Marta; Nogués Solan, Francesc Xavier; Sorli Redó, M. Luisa; Güerri Fernández, Roberto (Nature Research, 2022)
    One of the hallmarks of SARS-CoV-2 infection is an induced immune dysregulation, in some cases resulting in cytokine storm syndrome and acute respiratory distress syndrome (ARDS). Several physiological parameters are altered ...
  • Common and rare variants of WNT16, DKK1 and SOST and their relationship with bone mineral density
    Martínez-Gil, Núria; Roca Ayats, Neus; Monistrol-Mula, Anna; García-Giralt, Natalia; Diez-Perez, Adolfo; Nogués Solan, Francesc Xavier; Mellibovsky, Leonardo; Grinberg, Daniel; Balcells, Susana (Nature Research, 2018)
    Numerous GWAS and candidate gene studies have highlighted the role of the Wnt pathway in bone biology. Our objective has been to study in detail the allelic architecture of three Wnt pathway genes: WNT16, DKK1 and SOST, ...
  • Comparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption
    López Montesinos, Inmaculada; Arrieta Aldea, Itziar; Dicastillo, Aitor; Zuccarino, Flavio; Sorli Redó, M. Luisa; Güerri Fernández, Roberto; Arnau-Barrés, Isabel; Milagro Montero, Maria; Siverio-Parès, Ana; Duran Jordà, Xavier, 1974-; Arenas-Miras, María Del Mar; Brasé Arnau, Ariadna; Cañas-Ruano, Esperanza; Castañeda, Silvia; Kamber, Ignacio Domingo; Gómez Junyent, Joan; Pelegrín, Iván; Sánchez Martínez, Francisca; Sendra, Elena; Suaya Leiro, Lucía; Villar García, Judit; Nogués Solan, Francesc Xavier; Grau Cerrato, Santiago; Knobel Freud, Hernando; Gómez-Zorrilla, Silvia; Horcajada Gallego, Juan Pablo; COVID-MAR Group (Oxford University Press, 2022)
    Background: To compare clinical characteristics, outcomes, and resource consumption of patients with COVID-19 and seasonal influenza requiring supplemental oxygen. Methods: Retrospective cohort study conducted at a ...
  • Current situation of shared decision making in osteoporosis: A comprehensive literature review of patient decision aids and decision drivers
    Nogués Solan, Francesc Xavier; Carbonell, María Cristina; Canals, Laura; Lizán, Luis; Palacios, Santiago (Wiley, 2022)
    Background and aims: Osteoporosis is a systemic skeletal disease characterized by low bone mass and microstructural deterioration of bone tissues, resulting in bone fragility and increased fracture risk. It is the most ...
  • Effect of the tumor suppressor miR-320a on viability and functionality of human osteosarcoma cell Llnes compared to primary osteoblasts
    Ugarte Corbalán, Laura de, 1988-; Balcells, Susana; Güerri Fernández, Roberto; Grinberg, Daniel; Díez Pérez, Adolfo; Nogués Solan, Francesc Xavier; Garcia Giralt, Natàlia (MDPI, 2020)
    The miR-320a regulates a number of genes involved in various physiological processes. In particular, it has been reported as a tumor suppressor in several types of human cancers and involved in osteoporotic fracture and ...
  • Estudio del patrón de expresión de microRNAs en el hueso osteoporótico
    Garcia Giralt, Natàlia; Ugarte Corbalán, Laura de, 1988-; Yoskovitz, Guy; Güerri Fernández, Roberto; Grinberg, Daniel; Nogués Solan, Francesc Xavier; Mellibovsky, Leonardo; Balcells, Susana; Díez Pérez, Adolfo (Sociedad Española de Investigación Ósea y del Metabolismo Mineral (SEIOMM), 2016)
    Objetivos: Identificar microRNAs (miRNAs) diferencialmente expresados en muestras óseas con fractura osteoporótica respecto a huesos sanos. Material y métodos: Se extrajo RNA total a partir de hueso trabecular fresco del ...
  • Evolución de la DMO durante el tratamiento con inhibidores de aromatasa y su relación con el gen CYP11A1: estudio prospectivo de la cohorte B-ABLE
    Rodríguez Sanz, Maria, 1984-; Prieto-Alhambra, Daniel; Servitja Tormo, Sonia; Garcia Giralt, Natàlia; Garrigós, Laia; Albanell Mestres, Joan; Martinez-García, Maria; González, I.; Martos, Tamara; Díez Pérez, Adolfo; Tusquets Trias de Bes, Ignacio; Nogués Solan, Francesc Xavier (Sociedad Española de Investigación Ósea y del Metabolismo Mineral, 2015)
    Objetivos: El objetivo del estudio fue analizar los cambios en la densidad mineral ósea (DMO) a lo largo del tratamiento con inhibidores de aromatasa (IA) en la práctica clínica y evaluar la asociación entre el gen CYP11A1 ...
  • Expression profiling of microRNAs in human bone tissue from postmenopausal women
    Ugarte Corbalán, Laura de, 1988-; Serra-Vinardell, Jenny; Nonell Mazelon, Lara, 1972-; Balcells, Susana; Arnal, Magdalena; Nogués Solan, Francesc Xavier; Mellibovsky, Leonardo; Grinberg, Daniel; Díez Pérez, Adolfo; Garcia Giralt, Natàlia (Springer, 2018)
    Bone tissue is composed of several cell types, which express their own microRNAs (miRNAs) that will play a role in cell function. The set of total miRNAs expressed in all cell types configures the specific signature of the ...
  • Fracture risk in type 2 diabetic patients: A clinical prediction tool based on a large population-based cohort
    Martínez-Laguna, Daniel; Tebé, Cristian; Nogués Solan, Francesc Xavier; Javaid, M. Kassim; Cooper, Cyrus; Diez-Perez, Adolfo; Collins, Gary S.; Prieto-Alhambra, Daniel (Public Library of Science (PLoS), 2018)
    BACKGROUND: An increased fracture risk has been described as a complication of Type 2 diabetes mellitus (T2DM). Clinical prediction models for general population have a limited predictive accuracy for fractures in T2DM ...
  • Fracture risk reduction and safety by osteoporosis treatment compared with placebo or active comparator in postmenopausal women: systematic review, network meta-analysis, and meta-regression analysis of randomised clinical trials
    Händel, Mina Nicole; Nogués Solan, Francesc Xavier; Abrahamsen, Bo (BMJ Publishing Group, 2023)
    Objective: To review the comparative effectiveness of osteoporosis treatments, including the bone anabolic agents, abaloparatide and romosozumab, on reducing the risk of fractures in postmenopausal women, and to characterise ...
  • Functional analyses of four CYP1A1 missense mutations present in patients with atypical femoral fractures
    Ugartondo, Nerea; Martínez-Gil, Núria; Esteve, Mònica; Garcia Giralt, Natàlia; Roca Ayats, Neus; Ovejero Crespo, Diana; Nogués Solan, Francesc Xavier; Díez Pérez, Adolfo; Rabionet, Raquel; Grinberg, Daniel; Balcells, Susana (MDPI, 2021)
    Osteoporosis is the most common metabolic bone disorder and nitrogen-containing bisphosphonates (BP) are a first line treatment for it. Yet, atypical femoral fractures (AFF), a rare adverse effect, may appear after prolonged ...
  • Functional assessment of coding and regulatory variants from the DKK1 locus
    Martínez-Gil, Núria; Roca Ayats, Neus; Atalay, Nurgül; Pineda-Moncusí, Marta; Garcia Giralt, Natàlia; Van Hul, Wim; Boudin, Eveline; Ovejero Crespo, Diana; Mellibovsky, Leonardo; Nogués Solan, Francesc Xavier; Diez-Perez, Adolfo; Grinberg, Daniel; Balcells, Susana (Wiley, 2020)
    The DKK1 gene encodes an extracellular inhibitor of the Wnt pathway with an important role in bone tissue development, bone homeostasis, and different critical aspects of bone biology. Several BMD genome-wide association ...
  • Functional characterization of a GGPPS variant identified in atypical femoral fracture patients and delineation of the role of GGPPS in bone-relevant cell types
    Roca Ayats, Neus; Ng, Pei Ying; García-Giralt, Natalia; Falcó-Mascaró, Maite; Cozar, Mónica; Abril Ferrando, Josep Francesc; Quesada-Gómez, J.M.; Prieto-Alhambra, Daniel; Nogués Solan, Francesc Xavier; Dunford, James E.; Russell, R. Graham; Baron, Roland; Grinberg, Daniel; Balcells, Susana; Díez Pérez, Adolfo (Wiley, 2018)
    Atypical femoral fractures (AFFs) are a rare but potentially devastating event, often but not always linked to bisphosphonate (BP) therapy. The pathogenic mechanisms underlying AFFs remain obscure, and there are no tests ...
  • Functional characterization of the C7ORF76 genomic region, a prominent GWAS signal for osteoporosis in 7q21.3
    Roca Ayats, Neus; Martínez-Gil, Núria; Cozar, Mónica; Gerousi, Marina; Garcia Giralt, Natàlia; Ovejero Crespo, Diana; Mellibovsky, Leonardo; Nogués Solan, Francesc Xavier; Díez Pérez, Adolfo; Grinberg, Daniel; Balcells, Susana (Elsevier, 2019)
    Genome-wide association studies (GWAS) have repeatedly identified genetic variants associated with bone mineral density (BMD) and osteoporotic fracture in non-coding regions of C7ORF76, a poorly studied gene of unknown ...
  • Gene network of susceptibility to atypical femoral fractures related to bisphosphonate treatment
    Garcia Giralt, Natàlia; Roca Ayats, Neus; Abril Ferrando, Josep Francesc; Martínez-Gil, Núria; Ovejero Crespo, Diana; Castañeda, Santos; Nogués Solan, Francesc Xavier; Grinberg, Daniel; Balcells, Susana; Rabionet, Raquel (MDPI, 2022)
    Atypical femoral fractures (AFF) are rare fragility fractures in the subtrocantheric or diaphysis femoral region associated with long-term bisphosphonate (BP) treatment. The etiology of AFF is still unclear even though a ...
  • Genetic analysis in a familial case with high bone mineral density suggests additive effects at two loci
    Martínez-Gil, Núria; Ovejero Crespo, Diana; Garcia Giralt, Natàlia; Bruque, Carlos David; Mellibovsky, Leonardo; Nogués Solan, Francesc Xavier; Rabionet, Raquel; Grinberg, Daniel; Balcells, Susana (Wiley, 2022)
    Osteoporosis is the most common bone disease, characterized by a low bone mineral density (BMD) and increased risk of fracture. At the other end of the BMD spectrum, some individuals present strong, fracture-resistant, ...

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