Browsing by Author "Nikolaou, Christoforos"

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  • SEGCOND predicts putative transcriptional condensate-associated genomic regions by integrating multi-omics data
    Klonizakis, Antonios; Nikolaou, Christoforos; Graf, T. (Thomas) (Oxford University Press, 2023)
    Motivation: The compartmentalization of biochemical reactions, involved in the activation of gene expression in the eukaryotic nucleus, leads to the formation of membraneless bodies through liquid-liquid phase separation. ...
  • Structural constraints revealed in consistent nucleosome positions in the genome of S. cerevisiae
    Nikolaou, Christoforos; Althammer, Sonja Daniela; Beato, Miguel; Guigó Serra, Roderic (BioMed Central, 2010)
    BACKGROUND: Recent advances in the field of high-throughput genomics have rendered possible the performance of genome-scale studies to define the nucleosomal landscapes of eukaryote genomes. Such analyses are aimed towards ...
  • The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency
    Athanasouli, Paraskevi; Balli, Martina; De Jaime-Soguero, Anchel; Boel, Annekatrien; Papanikolaou, Sofia; van der Veer, Bernard K.; Janiszewski, Adrian; Vanhessche, Tijs; Francis, Annick; El Laithy, Youssef; Lo Nigro, Antonio; Aulicino, Francesco, 1987-; Koh, Kian Peng; Pasque, Vincent; Cosma, Maria Pia, 1970-; Verfaillie, Catherine; Zwijsen, An; Heindryckx, Björn; Nikolaou, Christoforos; Lluis Vinas, Frederic (Nature Research, 2023)
    Early during preimplantation development and in heterogeneous mouse embryonic stem cells (mESC) culture, pluripotent cells are specified towards either the primed epiblast or the primitive endoderm (PE) lineage. Canonical ...
  • Topoisomerase II regulates yeast genes with singular chromatin architectures
    Nikolaou, Christoforos; Bermúdez, Ignacio; Manichanh, Chaysavanh; García Martínez, José; Guigó Serra, Roderic; Pérez Ortín, José E.; Roca, Joaquim (Oxford University Press, 2013)
    Eukaryotic topoisomerase II (topo II) is the essential decatenase of newly replicated chromosomes and the main relaxase of nucleosomal DNA. Apart from these general tasks, topo II participates in more specialized functions. ...

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