Browsing by Author "Nawrot, Tim S."

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  • Association of greenspace exposure with telomere length in preschool children
    Miri, Mohammad; Prado Bert, Paula de; Alahabadi, Ahmad; Najafi, Moslem Lari; Rad, Abolfazl; Moslem, Alireza; Aval, Hamideh Ebrahimi; Ehrampoush, Mohammad Hassan; Bustamante Pineda, Mariona; Sakhvidi, Mohammad Javad Zare; Nawrot, Tim S.; Sunyer Deu, Jordi; Dadvand, Payam (Elsevier, 2020)
    Exposure to greenspace has been associated with a wide range of health benefits; however, the available evidence on the association of this exposure with telomere length (TL), an early marker of ageing, is still scarce. ...
  • Child buccal telomere length and mitochondrial DNA content as biomolecular markers of ageing in association with air pollution
    Hautekiet, Pauline; Nawrot, Tim S.; Janssen, Bram G.; Martens, Dries S.; De Clercq, Eva M.; Dadvand, Payam; Plusquin, Michelle; Bijnens, Esmée M.; Saenen, Nelly D. (Elsevier, 2021)
    Background: Pro-inflammatory conditions such as air pollution might induce biological ageing. However, the available evidence on such an impact in children is still very scarce. We studied in primary schoolchildren the ...
  • Children who sleep more may have longer telomeres: findings from the INMA birth cohort study
    Petermann-Rocha, Fanny; Valera-Gran, Desirée; Fernández-Pires, Paula; Martens, Dries S.; Júlvez Calvo, Jordi; Rodríguez Dehli, Cristina; Andiarena, Ainara; Lozano Relaño, Manuel; Fernández-Somoano, Ana; Lertxundi, Aitana; Llop, Sabrina; Guxens Junyent, Mònica; Nawrot, Tim S.; Navarrete-Muñoz, Eva-María (Nature Research, 2022)
    Background: Inadequate sleep duration has been suggested as a chronic stressor associated with changes in telomere length (TL). This study aimed to explore the association between sleep duration and TL using the INMA birth ...
  • Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth
    Alfano, Rossella; Zugna, Daniela; Barros, Henrique; Bustamante Pineda, Mariona; Chatzi, Leda; Ghantous, Akram; Herceg, Zdenko; Keski-Rahkonen, Pekka; Kok, Theo M. de; Nawrot, Tim S.; Relton, Caroline L.; Robinson, Oliver; Roumeliotaki, Theano; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Plusquin, Michelle (BioMed Central, 2023)
    Rapid postnatal growth may result from exposure in utero or early life to adverse conditions and has been associated with diseases later in life and, in particular, with childhood obesity. DNA methylation, interfacing ...
  • Cord blood metabolic signatures predictive of childhood overweight and rapid growth
    Handakas, Evangelos; Keski-Rahkonen, Pekka; Chatzi, Leda; Alfano, Rossella; Roumeliotaki, Theano; Plusquin, Michelle; Maitre, Léa; Richiardi, Lorenzo; Brescianini, Sonia; Scalbert, Augustin; Robinot, Nivonirina; Nawrot, Tim S.; Sassi, Franco; Vrijheid, Martine; Vineis, Paolo; Robinson, Oliver (Nature Research, 2021)
    Introduction: Metabolomics may identify biological pathways predisposing children to the risk of overweight and obesity. In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy ...
  • Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight
    Alfano, Rossella; Plusquin, Michelle; Robinson, Oliver; Brescianini, Sonia; Chatzi, Leda; Keski-Rahkonen, Pekka; Handakas, Evangelos; Maitre, Léa; Nawrot, Tim S.; Robinot, Nivonirina; Roumeliotaki, Theano; Sassi, Franco; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Zugna, Daniela (Nature Research, 2022)
    Background: The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight ...
  • Determinants of carbon load in airway macrophages in pregnant women
    Miri, Mohammad; Rezaei, Hossein; Momtaz, Seyed Mojtaba; Najafi, Moslem Lari; Adli, Abolfazl; Pajohanfar, Nasim Sadat; Abroudi, Mina; Bazghandi, Malihe Sadat; Razavi, Zahra; Alonso, Lucia; Tonne, Cathryn; Basagaña Flores, Xavier; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi; Nawrot, Tim S.; Dadvand, Payam (Elsevier, 2022)
    The airway macrophages carbon loading (AMCL) has been suggested to be a biomarker of the long-term exposure to air pollution; however, to date no study has characterized AMCL for the pregnancy period. Therefore, this study ...
  • Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes.
    Casas, Lidia; Sunyer Deu, Jordi; Tischer, Christina; Gehring, Ulrike; Wickman, Magnus; García Esteban, Raquel; Lehmann, Irina; Kull, Inger; Reich, Andreas; Lau, Susanne; Wijga, Alet; Antó i Boqué, Josep Maria; Nawrot, Tim S.; Heinrich, Joachim; Keil, Thomas; Torrent Quetglas, Maties (Wiley, 2015)
    BACKGROUND: Exposure to indoor allergens during early life may play a role in the development of the immune system and inception of asthma. OBJECTIVE: To describe the house dust mite (HDM) allergen concentrations in bedroom ...
  • Genetic regulation of newborn telomere length is mediated and modified by DNA methylation
    Wang, Congrong; Alfano, Rossella; Reimann, Brigitte; Hogervorst, Janneke; Bustamante Pineda, Mariona; De Vivo, Immaculata; Plusquin, Michelle; Nawrot, Tim S.; Martens, Dries S. (Frontiers, 2022)
    Telomere length at birth determines later life telomere length and potentially predicts ageing-related diseases. However, the genetic and epigenetic settings of telomere length in newborns have not been analyzed. In addition, ...
  • Obesity is associated with shorter telomeres in 8 year-old children
    Clemente Batalha Pardal, Diana, 1990-; Maitre, Léa; Bustamante Pineda, Mariona; Chatzi, Leda; Roumeliotaki, Theano; Fossati, Serena; Gražulevičienė, Regina; Gützkow, Kristine B.; Lepeule, Johanna; Martens, Dries S.; McEachan, Rosemary R.C.; Meltzer, Helle Margrete; Petraviciene, Inga; Slama, Rémy; Tamayo-Uria, Ibon; Urquiza, José M.; Vafeiadi, Marina, 1983-; Wright, John; Nawrot, Tim S.; Vrijheid, Martine (Nature Research, 2019)
    Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte ...
  • Prenatal ambient air pollution exposure, infant growth and placental mitochondrial DNA content in the INMA birth cohort
    Clemente Batalha Pardal, Diana, 1990-; Casas Sanahuja, Maribel; Janssen, Bram G.; Lertxundi, Aitana; Santa Marina, Loreto; Iñiguez, Carmen; Llop, Sabrina; Sunyer Deu, Jordi; Guxens Junyent, Mònica; Nawrot, Tim S.; Vrijheid, Martine (Elsevier, 2017)
    BACKGROUND: The association between prenatal air pollution exposure and postnatal growth has hardly been explored. Mitochondrial DNA (mtDNA), as a marker of oxidative stress, and growth at birth can play an intermediate ...
  • Prenatal ambient air pollution, placental mitochondrial DNA content, and birth weight in the INMA (Spain) and ENVIRONAGE (Belgium) birth cohorts.
    Clemente Batalha Pardal, Diana, 1990-; Casas Sanahuja, Maribel; Vilahur Chiaraviglio, Nadia, 1982-; Bustamante Pineda, Mariona; Carsin, Anne-Elie; Pedersen, Marie; Santa Marina, Loreto; Vrijheid, Martine; Sunyer Deu, Jordi; Nawrot, Tim S. (National Institute of Environmental Health Sciences, 2016)
    BACKGROUND: Mitochondria are sensitive to environmental toxicants due to their lack of repair capacity. Changes in mitochondrial DNA (mtDNA) content may represent a biologically relevant intermediate outcome in mechanisms ...
  • Prenatal and childhood traffic-related air pollution exposure and telomere length in european children: The HELIX Project
    Clemente Batalha Pardal, Diana, 1990-; Vrijheid, Martine; Martens, Dries S.; Bustamante Pineda, Mariona; Chatzi, Leda; Danileviciute, Asta; de Castro, Montserrat; Gražulevičienė, Regina; Gutzkow, Kristine B.; Lepeule, Johanna; Maitre, Léa; McEachan, Rosemary R.C.; Robinson, Oliver; Schwarze, Per E.; Tamayo-Uria, Ibon; Vafeiadi, Marina, 1983-; Wright, John; Slama, Rémy; Nieuwenhuijsen, Mark J.; Nawrot, Tim S. (National Institute of Environmental Health Sciences, 2019)
    Background: Telomere length is a molecular marker of biological aging. Objective: Here we investigated whether early-life exposure to residential air pollution was associated with leukocyte telomere length (LTL) at 8 y of ...
  • Prenatal exposure to phthalates and phenols and preclinical vascular health during early adolescence
    Montazeri, Parisa, 1988-; Fossati, Serena; Warembourg, Charline; Casas Sanahuja, Maribel; Clemente Batalha Pardal, Diana, 1990-; Garcia-Esteban, Raquel; Nawrot, Tim S.; Vrijheid, Martine (Elsevier, 2022)
    Background and aim: Exposure to endocrine-disrupting chemicals may increase cardiovascular risk from early life, but studies in children have shown inconsistent results, most focused on analysis of single chemicals, and ...
  • Residential green space improves cognitive performances in primary schoolchildren independent of traffic-related air pollution exposure
    Saenen, Nelly D.; Nawrot, Tim S.; Hautekiet, Pauline; Hautekiet, Pauline; Wang, Congrong; Roels, Harry A.; Dadvand, Payam; Plusquin, Michelle; Bijnens, Esmée M. (BioMed Central, 2023)
    Cognitive performances of schoolchildren have been adversely associated with both recent and chronic exposure to ambient air pollution at the residence. In addition, growing evidence indicates that exposure to green space ...
  • Sedentary behaviour and telomere length shortening during early childhood: evidence from the multicentre prospective INMA Cohort Study
    Prieto-Botella, Daniel; Martens, Dries S.; Valera-Gran, Desirée; Subiza-Pérez, Mikel; Tardón, Adonina; Lozano Relaño, Manuel; Casas, Maribel; Bustamante Pineda, Mariona; Jimeno-Rome, Alba; Fernández-Somoano, Ana; Llop, Sabrina; Vrijheid, Martine; Nawrot, Tim S.; Navarrete-Muñoz, Eva-María (MDPI, 2023)
    Sedentary behaviour (SB) may be related to telomere length (TL) attrition due to a possible pro-inflammatory effect. This study examined the association between parent-reported sedentary behaviour (SB) and leukocyte TL at ...