Browsing by Author "Nakayasu, Ernesto S."

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  • The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
    Ramos-Rodríguez, Mireia; Raurell Vila, Helena; Colli, Maikel Luis; Alvelos, Maria Inês; Subirana-Granés, Marc; Juan-Mateu, Jonàs; Norris, Richard; Turatsinze, Jean-Valery; Nakayasu, Ernesto S.; Webb-Robertson, Bobbie-Jo M.; Inshaw, Jamie R. J.; Marchetti, Piero; Piemonti, Lorenzo; Esteller, Manel; Todd, John A.; Metz, Thomas O.; Eizirik, Décio L.; Pasquali, Lorenzo (Nature Research, 2019)
    The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show that exposure to proinflammatory cytokines reveals a ...