Browsing by Author "Nadal Clanchet, Eulàlia de"

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  • Viéitez Manrique, Cristina, 1984-; Martínez Cebrián, Gerard, 1992-; Solé, Carme; Böttcher, René; Potel, Clement M.; Savitski, Mikhail M.; Onnebo, Sara; Fabregat, Marc; Shilatifard, Ali; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Oxford University Press, 2020)
    Cells have the ability to sense, respond and adapt to environmental fluctuations. Stress causes a massive reorganization of the transcriptional program. Many examples of histone post-translational modifications (PTMs) have ...
  • Canal de Torres, Berta, 1988-; Duch, Alba; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Taylor & Francis, 2018)
    Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a ...
  • Nadal Ribelles, Mariona, 1984-; Solé, Carme; Xu, Zhenyu; Steinmetz, Lars M.; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2014)
    Genomic analysis has revealed the existence of a large number of long noncoding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Cells display dramatic changes of gene expression upon ...
  • Canal de Torres, Berta, 1988- (Universitat Pompeu Fabra, 2018-02-16)
    In response to multiple internal and external stresses, yeast cells activate a common transcriptional response known as the Environmental Stress Response (ESR), which can be problematic in S phase, when DNA is being ...
  • Nadal Ribelles, Mariona, 1984- (Universitat Pompeu Fabra, 2013-11-25)
    A fundamental property of living cells is the ability to sense and robustly respond to fluctuations in their environment. In budding yeast (Saccharomyces cerevisiae) changes in extracellular osmolarity are sensed by the ...
  • Zapater Enrique, Meritxell (Universitat Pompeu Fabra, 2006-12-01)
    En el llevat Saccharomyces cerevisiae els canvis en les condicions osmòtiques del medi extracel.lular són sensades per la MAP cinasa Hog1, la qual permet dur a terme l'adaptació cel.lular mitjançant la modulació de l'expressió ...
  • Solé, Carme; Nadal Ribelles, Mariona, 1984-; Kraft, Claudine; Peter, Matthias; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Nature Publishing Group, 2011)
    Protein ubiquitylation is a key process in the regulation of many cellular processes. The balance between the activity of ubiquitin ligases and that of proteases controls the level of ubiquitylation. In response to ...
  • Duch, Alba; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2013)
    Transcription during S phase needs to be spatially and temporally regulated to prevent collisions between the transcription and replication machineries. Cells have evolved a number of mechanisms to make both processes ...
  • Urrios Garcia, Arturo, 1990- (Universitat Pompeu Fabra, 2017-11-27)
    Biological systems gather information from the environment and perform computations at multiple levels. Advancements in molecular biology and techniques for cell manipulation, genome engineering and DNA synthesis among ...
  • Carbonell Núñez, Caterina, 1987-; Ulsamer, Arnau; Vivori, Claudia, 1989-; Papasaikas, Panagiotis; Böttcher, René; Joaquin i Caudet, Manel; Miñana Gómez, Belén; Tejedor Vaquero, Juan Ramón, 1984-; Nadal Clanchet, Eulàlia de; Valcárcel, J. (Juan); Posas Garriga, Francesc (Elsevier, 2019)
    Alternative splicing is a prevalent mechanism of gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps ...
  • Nadal Ribelles, Mariona, 1984-; Mas Martín, Glòria; Millán Zambrano, Gonzalo; Solé, Carme; Ammerer, Gustav; Chávez, Sebastián; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Oxford University Press, 2015)
    Chromatin remodeling is essential for proper adaptation to extracellular stimuli. The p38-related Hog1 SAPK is an important regulator of transcription that mediates chromatin remodeling upon stress. Hog1 targets the RSC ...
  • Tognetti, Silvia; Jiménez, Javier; Viganò, Matteo; Duch, Alba; Queralt Badia, Ethel; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (National Academy of Sciences, 2020)
    Adaptation to environmental changes is crucial for cell fitness. In Saccharomyces cerevisiae, variations in external osmolarity trigger the activation of the stress-activated protein kinase Hog1 (high-osmolarity glycerol ...
  • Nadal Ribelles, Mariona, 1984-; Conde Pueyo, Núria, 1983-; Flores, Oscar; González-Vallinas Rostes, Juan, 1983-; Eyras Jiménez, Eduardo; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (BioMed Central, 2012)
    Cells are subjected to dramatic changes of gene expression upon environmental changes. Stress/ncauses a general down-regulation of gene expression together with the induction of a set of stress-responsive/ngenes. The ...
  • Martínez Cebrián, Gerard, 1992- (Universitat Pompeu Fabra, 2019-12-03)
    Upon environmental stresses such as temperature fluctuations or increases in osmolarity, yeast Saccharomyces cerevisiae induces a transcriptional reprograming in order to survive and adapt to the stress. Histone ...
  • Macía, Javier; Manzoni, Romilde; Conde Pueyo, Núria, 1983-; Urrios, Arturo; Nadal Clanchet, Eulàlia de; Solé Vicente, Ricard, 1962-; Posas Garriga, Francesc (Public Library of Science (PLoS), 2016)
    Engineered synthetic biological devices have been designed to perform a variety of functions from sensing molecules and bioremediation to energy production and biomedicine. Notwithstanding, a major limitation of in vivo ...
  • Stojanovski, Klement; Ferrar, Tony; Benisty, Hannah; Uschner, Friedemann; Delgado Blanco, Javier; Jimenez, Javier; Solé, Carme; Nadal Clanchet, Eulàlia de; Klipp, E., 1965-; Posas Garriga, Francesc; Serrano Pubull, Luis, 1982-; Kiel, Christina (Elsevier, 2017)
    The understanding of interaction dynamics in signaling pathways can shed light on pathway architecture and provide insights into targets for intervention. Here, we explored the relevance of kinetic rate constants of a key ...
  • Duch, Alba; Canal de Torres, Berta, 1988-; Barroso, Sonia I.; García Rubio, María Luisa; Seisenbacher, Gerhard; Aguilera, Andrés; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Nature Publishing Group, 2018)
    Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have evolved strategies to prevent such conflicts. However, little is known regarding how cells cope ...
  • Solé, Carme; Nadal Ribelles, Mariona, 1984-; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Springer, 2015)
    Eukaryotic cells have developed sophisticated systems to constantly monitor changes in the extracellular environment and to orchestrate a proper cellular response. To maximize survival, cells delay cell-cycle progression ...
  • Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Wiley, 2015)
    Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden changes in the environment. Several aspects of cell physiology change during adaptation. Major changes in gene expression are ...
  • Romero, Antonia M.; Martínez Pastor, Mar; Du, Gang; Solé, Carme; Carlos, María; Vergara, Sandra V.; Sanvisens, Nerea; Wohlschlegel, James A.; Toczyski, David P.; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Martínez-Pastor, María T.; Thiele, Dennis J.; Puig, Sergi (American Society for Microbiology, 2018)
    Iron is an indispensable micronutrient for all eukaryotic organisms due to its participation as a redox cofactor in many metabolic pathways. Iron imbalance leads to the most frequent human nutritional deficiency in the ...