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Browsing by Author "Muntasell i Castellví, Aura, 1972-"
Now showing items 1-20 of 24
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Sánchez-Martínez, Diego; Lanuza, Pilar M.; Gómez, Natalia; Muntasell i Castellví, Aura, 1972-; Cisneros, Elisa; Moraru, Manuela; Azaceta, Gemma; Anel, Alberto; Martínez-Lostao, Luis; Villalba, Martin; Palomera, Luis; Vilches, Carlos; García Marco, José A.; Pardo, Julián (Frontiers, 2016)Mutational status of TP53 together with expression of wild-type (wt) IGHV represents the most widely accepted biomarkers, establishing a very poor prognosis in B-cell chronic lymphocytic leukemia (B-CLL) patients. Adoptive ...
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López-Botet, Miguel; Maria, Andrea de; Muntasell i Castellví, Aura, 1972-; Della Chiesa, Mariella; Vilches, Carlos (Elsevier, 2023)Human cytomegalovirus (HCMV) infection exerts broad effects on the immune system. These include the differentiation and persistent expansion of a mature NK cell subset which displays a characteristic phenotypic and functional ...
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Pupuleku, Aldi, 1985- (Universitat Pompeu Fabra, 2017-11-10)Human cytomegalovirus (HCMV) infection induces a persistent reconfiguration of the NK cell compartment in some individuals, promoting the development of a mature NK cell subset, hallmarked by high expression levels of the ...
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Meazza, Raffaella; Falco, Michela; Canevali, Paolo; Loiacono, Fabrizio; Colomar-Carando, Natalia; Muntasell i Castellví, Aura, 1972-; Rea, Anna; Mingari, Maria Cristina; Locatelli, Franco; Moretta, Lorenzo; López-Botet, Miguel; Pende, Daniela (Wiley, 2022)The phenotypic identification of different NK cell subsets allows more in-depth characterization of KIR repertoire and function, which are of potential interest in KIR and disease association studies. KIR genes are highly ...
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Asenjo, Judit; Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel; Moraru, Manuela; Vilches, Carlos (Wiley, 2021)
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Sabbaghi Mehrjardi, Mohammad Ali; Gil Gómez, Gabriel; Guardia Laguarta, Cristina; Servitja Tormo, Sonia; Arpí Llucià, Oriol; Menendez Romero, Silvia; Arumí, Montserrat; Serrano, Laia; Salido Galeote, Marta; Muntasell i Castellví, Aura, 1972-; Martínez-García, Maria; Tusquets Trias de Bes, Ignacio; Rovira Guerín, Ana; Albanell Mestres, Joan (American Association for Cancer Research (AACR), 2017)Purpose: Trastuzumab-emtansine (T-DM1) is a standard treatment in advanced HER2-positive breast cancer. However, resistance inevitably occurs. We aimed to identify mechanisms of acquired T-DM1 resistance.Experimental Design: ...
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López-Botet, Miguel; Muntasell i Castellví, Aura, 1972-; Martínez-Rodriguez, José E.; López-Montañés, María; Costa-García, Marcel; Pupuleku, Aldi, 1985- (Elsevier, 2016)Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. ...
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Asenjo, Judit; Moraru, Manuela; Al-Akioui-Sanz, Karima; Altadill, Mireia; Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel; Vilches, Carlos (Wiley, 2022)NK cells monitor altered molecular patterns in tumors and infected cells through an ample array of receptors. Two families of evolutionarily distant receptors have converged to enable human NK cells to sense levels of HLA ...
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López-Botet, Miguel; Vilches, Carlos; Redondo Pachón, María Dolores; Muntasell i Castellví, Aura, 1972-; Pupuleku, Aldi, 1985-; Yélamos López, José; Pascual Santos, Julio; Crespo Barrio, Marta (Frontiers, 2017)Allograft rejection constitutes a major complication of solid organ transplantation requiring prophylactic/therapeutic immunosuppression, which increases susceptibility of patients to infections and cancer. Beyond the ...
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Pupuleku, Aldi, 1985-; Costa-García, Marcel; Farré, Domènec; Hengel, Hartmut; Angulo Aguado, Ana; Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel (Frontiers, 2017)Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a mature NK cell subset, which displays high surface levels of the activating CD94/NKG2C NK cell receptor, together with ...
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Falco, Michela; Meazza, Raffaella; Alicata, Claudia; Canevali, Paolo; Muntasell i Castellví, Aura, 1972-; Bottino, Cristina; Moretta, Lorenzo; Pende, Daniela; López-Botet, Miguel (Wiley, 2022)Killer immunoglobulin-like receptor (KIR) genes code for a family of inhibitory and activating receptors, finely tuning NK cell function. Numerous studies reported the relevance of KIR allelic polymorphism on KIR expression, ...
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Casals López, Ferran; Sikora, Martin, 1976-; Laayouni, Hafid, 1968-; Montanucci, Ludovica, 1978-; Muntasell i Castellví, Aura, 1972-; Lazarus, Ross; Calafell i Majó, Francesc; Awadalla, Philip; Netea, Mihai G; Bertranpetit, Jaume, 1952- (BioMed Central, 2011)Background: Pathogens have represented an important selective force during the adaptation of modern human populations to changing social and other environmental conditions. The evolution of the immune system has therefore ...
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Cisneros, Elisa; Moraru, Manuela; Gómez-Lozano, Natalia; Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel; Vilches, Carlos (Frontiers, 2020)Inhibitory Killer-cell Immunoglobulin-like Receptors (KIR) specific for HLA class I molecules enable human natural killer cells to monitor altered antigen presentation in pathogen-infected and tumor cells. KIR genes display ...
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Costa García, Marcel, 1989-; Ataya Fernández, Michelle, 1993-; Moraru, Manuela; Vilches, Carlos; López-Botet, Miguel; Muntasell i Castellví, Aura, 1972- (Frontiers, 2019)Natural killer (NK) cells play a dual role in the defense against viral pathogens by directly lysing infected cells as well as by regulating anti-viral T cell immunity. Infection by human cytomegalovirus (HCMV) promotes a ...
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Holst Hansen, Thomas; Abad Adan, Elena; Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel; Jensen, Mogens; Trusina, Ala; García Ojalvo, Jordi (Elsevier, 2017)Allele number, or zygosity, is a clear determinant of gene expression in diploid cells. However, the relationship between the number of copies of a gene and its expression can be hard to anticipate, especially when the ...
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López Montañés, María, 1987- (Universitat Pompeu Fabra, 2016-11-25)El citomegalovirus humano (HCMV) promueve una redistribución del compartimento de células Natural Killer (NK) marcada por un incremento de las células NK maduras que expresan niveles elevados del receptor activador CD94/NKG2C. ...
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Muntasell i Castellví, Aura, 1972-; Cabo, Mariona, 1991-; Servitja Tormo, Sonia; Tusquets Trias de Bes, Ignacio; Martínez-García, Maria; Rovira Guerín, Ana; Rojo, Federico; Albanell Mestres, Joan; López-Botet, Miguel (Frontiers, 2017)Overexpression of the human epidermal growth factor receptor 2 (HER2) defines a subgroup of breast tumors with aggressive behavior. The addition of HER2-targeted antibodies (i.e., trastuzumab, pertuzumab) to chemotherapy ...
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Costa García, Marcel, 1989- (Universitat Pompeu Fabra, 2018-06-11)Human cytomegalovirus (HCMV) infection induces persistent changes in the host immune system, namely a sustained expansion of effector memory and cytotoxic specific T lymphocytes, the production of antibodies (Ab) and, in ...
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Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel (American Association for Cancer Research, 2016)The report by Curti et al. highlightsthe potential of NK cell-based adoptive cellular immunotherapy in oncology,currently boosted by advances in the knowledge on NK cell biology and in their ex-vivo GMP manipulation.Several ...
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Alari-Pahissa, Elisenda; Ataya Fernández, Michelle, 1993-; Moraitis, Ilias; Campos Ruiz, Miriam; Altadill, Mireia; Muntasell i Castellví, Aura, 1972-; Moles, Anna; López-Botet, Miguel (Public Library of Science (PLoS), 2021)Epstein Barr virus (EBV) causes a highly prevalent and lifelong infection contributing to the development of some malignancies. In addition to the key role played by T cells in controlling this pathogen, NK cells mediate ...
Now showing items 1-20 of 24
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