Browsing by Author "Muntané, Gerard"

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  • 267 spanish exomes reveal population-specific differences in disease-related genetic variation
    Dopazo, Joaquín; Rodríguez, Juan Antonio; Daub, Josephine T.; Muntané, Gerard; Navarro i Cuartiellas, Arcadi, 1969-; Antiñolo, Guillermo (Oxford University Press, 2016)
    Recent results from large-scale genomic projects suggest that allele frequencies, which are highly relevant for medical purposes, differ considerably across different populations. The need for a detailed catalog of local ...
  • Biological processes modulating longevity across primates: a phylogenetic genome-phenome analysis
    Muntané, Gerard; Farré, Xavier; Rodríguez Pérez, Juan Antonio, 1985-; Pegueroles Queralt, Maria Cinta; Hughes, David; Magalhães, João Pedro de; Gabaldón Estevan, Juan Antonio, 1973-; Navarro i Cuartiellas, Arcadi, 1969- (Oxford University Press, 2018)
    Aging is a complex process affecting different species and individuals in different ways. Comparing genetic variation across species with their aging phenotypes will help understanding the molecular basis of aging and ...
  • CAAStools: a toolbox to identify and test Convergent Amino Acid Substitutions
    Barteri, Fabio; Valenzuela, Alejandro; Farré, Xavier; Juan, David; Muntané, Gerard; Esteve Altava, Borja; Navarro i Cuartiellas, Arcadi, 1969- (Oxford University Press, 2023)
    Motivation: Coincidence of Convergent Amino Acid Substitutions (CAAS) with phenotypic convergences allow pinpointing genes and even individual mutations that are likely to be associated with trait variation within their ...
  • Coexpression of the discoidin domain receptor 1 gene with oligodendrocyte-related and schizophrenia risk genes in the developing and adult human brain
    Muntané, Gerard; Chillida, Marc; Aranda, Selena; Navarro i Cuartiellas, Arcadi, 1969-; Vilella, Elisabet (Wiley, 2021)
    Background: Discoidin domain receptor tyrosine kinase 1 (DDR1) is present in multiple types of epithelial cells and is highly expressed in the nervous system. Previous studies have revealed that DDR1 is involved in ...
  • Comparative analysis of mammal genomes unveils key genomic variability for human life span
    Farré, Xavier; Molina, Ruben; Barteri, Fabio; Timmers, Paul R.H.J.; Joshi, Peter K.; Oliva Miguel, Baldomero; Acosta, Sandra; Esteve Altava, Borja; Navarro i Cuartiellas, Arcadi, 1969-; Muntané, Gerard (Oxford University Press, 2021)
    The enormous mammal's lifespan variation is the result of each species' adaptations to their own biological trade-offs and ecological conditions. Comparative genomics have demonstrated that genomic factors underlying both, ...
  • From populations to species : Unravelling the unknowns of ageing with two complementary approaches
    Farré Ramon, Xavier (Universitat Pompeu Fabra, 2022-07-08)
    Ageing is a very complex phenotype that has been widely studied, but is still largely unknown. Most of the studies focus on a single species, or on performing genome wide association studies in human cohorts, but this only ...
  • Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
    Karlsson Linnér, Richard; González, Juan Ramón; Muntané, Gerard; Morcillo Suárez, Carlos, 1969-; Navarro i Cuartiellas, Arcadi, 1969-; Beauchamp, Jonathan P. (Nature Research, 2019)
    Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky ...
  • Human genetic adaptation related to cellular zinc homeostasis
    Roca-Umbert Würth, Ana; García Calleja, Jorge; Vogel González, Marina, 1993-; Fierro Villegas, José Alejandro; Ill-Raga, Gerard, 1982-; Herrera-Fernández, Víctor; Bosnjak, Anja; Muntané, Gerard; Gutiérrez García, Esteban; Campelo, Felix; Vicente García, Rubén, 1978-; Bosch Fusté, Elena (Public Library of Science (PLoS), 2023)
    SLC30A9 encodes a ubiquitously zinc transporter (ZnT9) and has been consistently suggested as a candidate for positive selection in humans. However, no direct adaptive molecular phenotype has been demonstrated. Our results ...
  • Polygenic risk scores enhance prediction of body mass index increase in individuals with a first episode of psychosis
    Muntané, Gerard; Vázquez-Bourgon, Javier; Sada, Ester; Martorell, Lourdes; Papiol, Sergi; Bosch Fusté, Elena; Navarro i Cuartiellas, Arcadi, 1969-; Crespo-Facorro, Benedicto; Vilella, Elisabet (Cambridge University Press, 2023)
    Background: Individuals with a first episode of psychosis (FEP) show rapid weight gain during the first months of treatment, which is associated with a reduction in general physical health. Although genetics is assumed to ...
  • Shared genetic architecture between attention-deficit/hyperactivity disorder and lifespan
    Vilar-Ribó, Laura; Cabana-Domínguez, Judit; Martorell, Lourdes; Ramos-Quiroga, Josep Antoni; Sanchez-Roige, Sandra; Palmer, Abraham A.; Vilella, Elisabet; Ribasés, Marta; Muntané, Gerard; Soler Artigas, María (Springer, 2023)
    There is evidence linking ADHD to a reduced life expectancy. The mortality rate in individuals with ADHD is twice that of the general population and it is associated with several factors, such as unhealthy lifestyle ...
  • The shared genetic architecture of schizophrenia, bipolar disorder and lifespan
    Muntané, Gerard; Farré, Xavier; Bosch Fusté, Elena; Martorell, Lourdes; Navarro i Cuartiellas, Arcadi, 1969-; Vilella, Elisabet (Springer, 2021)
    Psychiatric disorders such as Schizophrenia (SCZ) and Bipolar Disorder (BD) represent an evolutionary paradox, as they exhibit strong negative effects on fitness, such as decreased fecundity and early mortality, yet they ...

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