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Browsing by Author "Muñoz López, Francisco José, 1964-"

Browsing by Author "Muñoz López, Francisco José, 1964-"

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  • Ill-Raga, Gerard, 1982-; Palomer, Ernest; Wozniak, Matthew A; Ramos Fernández, Eva, 1984-; Bosch Morató, Mònica, 1986-; Tajes Orduña, Marta; Guix Ràfols, Francesc Xavier; Galán, José J; Clarimón Echevarría, Jordi; Antúnez, Carmen; Real, Luis M; Boada, Mercè; Itzhaki, Ruth F; Fandos, César; Muñoz López, Francisco José, 1964- (Public Library of Science (PLoS), 2011)
    BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively inhibited due to the presence of the 5′untranslated region (5′UTR) ...
  • Picón-Pagès, Pol; Gutiérrez, Daniela A.; Barranco Almohalla, Alejandro; Crepin, Giulia; Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Guix Ràfols, Francesc Xavier; Menéndez, Silvia; Arumí Uría, Montserrat; Vicente García, Rubén, 1978-; Álvarez, Alejandra R.; Muñoz López, Francisco José, 1964- (Hindawi, 2020)
    Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity ...
  • Guivernau Almazán, Biuse, 1988-; Bonet Martínez, Jaume, 1982-; Valls Comamala, Victòria, 1987-; Bosch Morató, Mònica, 1986-; Godoy Zeballos, Juan Alejandro, 1959-; Inestrosa, Nibaldo C.; Perálvarez Marín, Alex; Fernández-Busquets, Xavier; Andreu Martínez, David; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Society for Neuroscience, 2016)
    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the pathological aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can switch from helicoidal to β-sheet conformation, promoting its ...
  • Godoy Zeballos, Juan Alejandro, 1959- (Universitat Pompeu Fabra, 2018-06-29)
    Las mitocondrias y su función metabólica cambian con el envejecimiento y pueden ser el factor más importante en el desarrollo de diferentes enfermedades neurodegenerativas relacionadas con la edad, incluida la enfermedad ...
  • Aso Pérez, Ester; Palomer, Ernest; Juvés, Salvador; Maldonado, Rafael, 1961-; Muñoz López, Francisco José, 1964-; Ferrer, Isidre (IOS Press, 2012)
    The present study shows that chronic administration of the cannabinoid receptor type 1 (CB1) receptor agonist arachidonyl-2-chloroethylamide (ACEA) at pre-symptomatic or at early symptomatic stages, at a non-amnesic dose, ...
  • Núñez Ollé, Marc, 1984-; Jung, Carole; Terré, Berta; Balsiger, Norman A.; Plata, Cristina; Roset i Huguet, Ramon; Pardo Pastor, Carlos; Garrido, Marta; Rojas, Santiago; Alameda Quitllet, Francisco; Lloreta Trull, Josep, 1958-; Martín Caballero, Juan; Flores, Juana M.; Stracker, Travis; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964-; Gil Gómez, Gabriel (Impact Journals, 2017)
    Cyclin O (encoded by CCNO) is a member of the cyclin family with regulatory functions in ciliogenesis and apoptosis. Homozygous CCNO mutations have been identified in human patients with Reduced Generation of Multiple ...
  • Castro, Patricio A.; Ramírez, Alejandra E.; Sepúlveda, Fernando J.; Peters, Christian; Fierro, Humberto; Waldron, Javier; Luza, Sandra; Fuentealba, Jorge; Muñoz López, Francisco José, 1964-; De Ferrari, Giancarlo V.; Bush, Ashley I.; Aguayo, Luis G.; Opazo, Carlos M. (Frontiers, 2014)
    Extracellular and intracellular copper and zinc regulate synaptic activity and plasticity, which may impact brain functionality and human behavior. We have found that a metal coordinating molecule, Neocuproine, transiently ...
  • Ortiz Romero, Paula; Borralleras Fumaña, Cristina, 1988-; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Albericio, Guillermo; Muñoz López, Francisco José, 1964-; Pérez Jurado, Luis Alberto; Campuzano Uceda, María Victoria (Public Library of Science (PLoS), 2018)
    Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by a heterozygous deletion of 26-28 genes at chromosome band 7q11.23. The complete deletion (CD) mouse model mimics the most common deletion found in ...
  • Pacheco, Carla R.; Morales, Camila N.; Ramírez, Alejandra E.; Muñoz López, Francisco José, 1964-; Gallegos, Scarlet S.; Caviedes, Pablo A.; Aguayo, Luis G.; Opazo, Carlos M. (Wiley, 2015)
    It has been postulated that the accumulation of extracellular α-synuclein (α-syn) might alter the neuronal membrane by formation of 'pore-like structures' that will lead to alterations in ionic homeostasis. However, this ...
  • Ill-Raga, Gerard, 1982-; Palomer, Ernest; Ramos Fernández, Eva, 1984-; Guix Ràfols, Francesc Xavier; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Tajes Orduña, Marta; Valls Comamala, Victòria, 1987-; Jiménez Conde, Jordi; Ois Santiago, Angel Javier; Gil Gómez, Gabriel; Alameda Quitllet, Francisco; Roquer, Jaume; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Elsevier, 2015)
    Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its correct management. Ischemia produces increased nitric oxide ...
  • Picón-Pagès, Pol; Garcia Buendia, Joan; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood flow and also has important roles in intracellular signaling in neurons from the regulation of the neuronal metabolic status to ...
  • Ramos Fernández, Eva, 1984-; Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Vargas, Lina M.; Busquets Garcia, Arnau, 1985-; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Valls Comamala, Victòria, 1987-; Gomis González, Maria, 1988-; Grau, Cristina; Fandos, César; Rosen, Mark D.; Rabinowitz, Michael H.; Inestrosa, Nibaldo C.; Maldonado, Rafael, 1961-; Altafaj, Xavier; Ozaita Mintegui, Andrés, 1969-; Álvarez, Alejandra R.; Vicente García, Rubén, 1978-; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Impact Journals, 2016)
    The activation of N-Methyl D-Aspartate Receptor (NMDAR) by glutamate is crucial in the nervous system function, particularly in memory and learning. NMDAR is composed by two GluN1 and two GluN2 subunits. GluN2B has been ...
  • Picón-Pagès, Pol; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Garcia-Buendia, Joan; Gutierrez, Daniela; Valle, Javier; Gómez-Casuso, Carmen E.S.; Sidelkivska, Valeriya; Alvarez, Alejandra; Perálvarez Marín, Alex; Suades, Albert; Fernàndez Busquets, Xavier; Andreu Martínez, David; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate ...
  • Bosch Morató, Mònica, 1986-; Iriondo, Cinta; Guivernau Almazán, Biuse, 1988-; Valls Comamala, Victòria, 1987-; Vidal, Noemí; Olivé, Montse; Querfurth, Henry; Muñoz López, Francisco José, 1964- (Impact Journals, 2016)
    GNE myopathy is an autosomal recessive muscular disorder of young adults characterized by progressive skeletal muscle weakness and wasting. It is caused by a mutation in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine ...
  • Vicario Orri, Elena, 1989- (Universitat Pompeu Fabra, 2017-10-03)
    The mechanisms by which amyloid beta (Aβ) causes synaptic dysfunction in Alzheimer’s disease (AD) remain elusive. Aβ is derived by sequential cleavage of the amyloid precursor protein (APP) and released from neurons, but ...
  • Tajes Orduña, Marta; Eraso Pichot, Abel; Rubio Moscardó, Fanny; Guivernau Almazán, Biuse, 1988-; Ramos Fernández, Eva, 1984-; Bosch Morató, Mònica, 1986-; Guix Ràfols, Francesc Xavier; Clarimón Echevarría, Jordi; Miscione, Gian Pietro; Boada, Mercè; Gil Gómez, Gabriel; Suzuki, Toshiharu; Molina, Henrik; Villà i Freixa, Jordi; Vicente García, Rubén, 1978-; Muñoz López, Francisco José, 1964- (IOS Press, 2014)
    Amyloid-β peptide (Aβ) aggregates induce nitro-oxidative stress, contributing to the characteristic neurodegeneration found in Alzheimer's disease (AD). One of the most strongly nitrotyrosinated proteins in AD is the ...
  • Tajes Orduña, Marta; Eraso Pichot, Abel; Rubio Moscardó, Fanny; Guivernau Almazán, Biuse, 1988-; Bosch Morató, Mònica, 1986-; Valls Comamala, Victòria, 1987-; Miscione, Gian Pietro; Villà i Freixa, Jordi; Suzuki, Toshiharu; Muñoz López, Francisco José, 1964- (Elsevier, 2014)
    Alzheimer's disease (AD) is characterized by the oxidative stress generated from amyloid β-peptide (Aβ) aggregates. It produces protein nitrotyrosination, after the reaction with nitric oxide to form peroxynitrite, being ...
  • Godoy Zeballos, Juan Alejandro, 1959-; Rios, Juvenal A.; Picón-Pagès, Pol; Herrera-Fernández, Víctor; Swaby, Bronte; Crepin, Giulia; Vicente García, Rubén, 1978-; Fernández-Fernández, José Manuel, 1967-; Muñoz López, Francisco José, 1964- (MDPI, 2021)
    Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic plasticity. Their functional integrity is ...
  • Guix Ràfols, Francesc Xavier; Wahle, Tina; Vennekens, Kristel; Snellinx, An; Chávez Gutiérrez, Lucía; Ill-Raga, Gerard, 1982-; Ramos Fernández, Eva, 1984-; Guardia Laguarta, Cristina; Lleó, Alberto; Arimon, Muriel; Berezovska, Oksana; Muñoz López, Francisco José, 1964-; Dotti, Carlos G.; De Strooper, Bart (Wiley-VCH Verlag, 2012)
    Inherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of Aβ42 versus Aβ40 peptide which is thought to drive the amyloid plaque formation in the brain of these patients. Little is known ...
  • Guivernau Almazán, Biuse, 1988- (Universitat Pompeu Fabra, 2016-06-10)
    Aggregation of the amyloid-β (Aβ) peptide to form oligomers and amyloid fibrils is a central event in the pathogenesis of Alzheimer’s disease (AD). This thesis aims to provide a better understanding of Aβ toxicity and the ...