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Browsing by Author "Muñoz López, Francisco José, 1964-"

Browsing by Author "Muñoz López, Francisco José, 1964-"

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  • Picón-Pagès, Pol; Bosch Morató, Mònica, 1986-; Subirana, Laia; Rubio-Moscardó, Francisca; Guivernau Almazán, Biuse, 1988-; Fanlo-Ucar, Hugo; Zeylan, Melisa Ece; Senyuz, Simge; Herrera-Fernández, Víctor; Vicente García, Rubén, 1978-; Fernández-Fernández, José Manuel, 1967-; García Ojalvo, Jordi; Gursoy, Attila; Keskin, Ozlem; Oliva Miguel, Baldomero; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Muñoz López, Francisco José, 1964- (MDPI, 2023)
    Alzheimer's disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent AD. To identify novel molecular players in Aβ toxicity, we carried ...
  • Ill-Raga, Gerard, 1982-; Palomer, Ernest; Wozniak, Matthew A; Ramos Fernández, Eva, 1984-; Bosch Morató, Mònica, 1986-; Tajes Orduña, Marta; Guix Ràfols, Francesc Xavier; Galán, José J; Clarimón Echevarría, Jordi; Antúnez, Carmen; Real, Luis M; Boada, Mercè; Itzhaki, Ruth F; Fandos, César; Muñoz López, Francisco José, 1964- (Public Library of Science (PLoS), 2011)
    BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively inhibited due to the presence of the 5′untranslated region (5′UTR) ...
  • Picón-Pagès, Pol; Gutiérrez, Daniela A.; Barranco Almohalla, Alejandro; Crepin, Giulia; Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Guix Ràfols, Francesc Xavier; Menéndez, Silvia; Arumí Uría, Montserrat; Vicente García, Rubén, 1978-; Álvarez, Alejandra R.; Muñoz López, Francisco José, 1964- (Hindawi, 2020)
    Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity ...
  • Picón-Pagès, Pol; Fanlo-Ucar, Hugo; Herrera-Fernández, Víctor; Ausellé Bosch, Sira; Galera López, Lorena, 1993-; Gutiérrez, Daniela A.; Ozaita Mintegui, Andrés, 1969-; Álvarez, Alejandra R.; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (MDPI, 2022)
    Alzheimer's disease (AD) is characterised by the presence of extracellular amyloid plaques in the brain. They are composed of aggregated amyloid beta-peptide (Aβ) misfolded into beta-sheets which are the cause of the AD ...
  • Guivernau Almazán, Biuse, 1988-; Bonet Martínez, Jaume, 1982-; Valls Comamala, Victòria, 1987-; Bosch Morató, Mònica, 1986-; Godoy Zeballos, Juan Alejandro, 1959-; Inestrosa, Nibaldo C.; Perálvarez Marín, Alex; Fernández-Busquets, Xavier; Andreu Martínez, David; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Society for Neuroscience, 2016)
    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the pathological aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can switch from helicoidal to β-sheet conformation, promoting its ...
  • Gallego-Villarejo, Lucía; Wallin, Cecilia; Król, Sylwia; Enrich-Bengoa, Jennifer; Suades, Albert; Aguilella-Arzo, Marcel; Gomara, Maria J.; Haro, Isabel; Wärmlander, Sebastian; Muñoz López, Francisco José, 1964-; Gräslund, Astrid; Perálvarez Marín, Alex (Elsevier, 2022)
    Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer's disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since ...
  • Aso Pérez, Ester; Palomer, Ernest; Juvés, Salvador; Maldonado, Rafael, 1961-; Muñoz López, Francisco José, 1964-; Ferrer, Isidre (IOS Press, 2012)
    The present study shows that chronic administration of the cannabinoid receptor type 1 (CB1) receptor agonist arachidonyl-2-chloroethylamide (ACEA) at pre-symptomatic or at early symptomatic stages, at a non-amnesic dose, ...
  • Núñez Ollé, Marc, 1984-; Jung, Carole; Terré, Berta; Balsiger, Norman A.; Plata, Cristina; Roset i Huguet, Ramon; Pardo Pastor, Carlos; Garrido, Marta; Rojas, Santiago; Alameda Quitllet, Francisco; Lloreta Trull, Josep, 1958-; Martín Caballero, Juan; Flores, Juana M.; Stracker, Travis; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964-; Gil Gómez, Gabriel (Impact Journals, 2017)
    Cyclin O (encoded by CCNO) is a member of the cyclin family with regulatory functions in ciliogenesis and apoptosis. Homozygous CCNO mutations have been identified in human patients with Reduced Generation of Multiple ...
  • Castro, Patricio A.; Ramírez, Alejandra E.; Sepúlveda, Fernando J.; Peters, Christian; Fierro, Humberto; Waldron, Javier; Luza, Sandra; Fuentealba, Jorge; Muñoz López, Francisco José, 1964-; De Ferrari, Giancarlo V.; Bush, Ashley I.; Aguayo, Luis G.; Opazo, Carlos M. (Frontiers, 2014)
    Extracellular and intracellular copper and zinc regulate synaptic activity and plasticity, which may impact brain functionality and human behavior. We have found that a metal coordinating molecule, Neocuproine, transiently ...
  • Molina Fernández, Rubén; Picón-Pagès, Pol; Barranco Almohalla, Alejandro; Crepin, Giulia; Herrera-Fernández, Víctor; García-Elías, Anna; Fanlo-Ucar, Hugo; Fernàndez Busquets, Xavier; García Ojalvo, Jordi; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Oxford University Press, 2022)
    Alzheimer's disease and Type 2 diabetes are pathological processes associated to ageing. Moreover, there are evidences supporting a mechanistic link between Alzheimer's disease and insulin resistance (one of the first ...
  • Ortiz Romero, Paula, 1994-; Borralleras Fumaña, Cristina, 1988-; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Albericio, Guillermo; Muñoz López, Francisco José, 1964-; Pérez Jurado, Luis Alberto; Campuzano Uceda, María Victoria (Public Library of Science (PLoS), 2018)
    Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by a heterozygous deletion of 26-28 genes at chromosome band 7q11.23. The complete deletion (CD) mouse model mimics the most common deletion found in ...
  • Sinigaglia, Barbara; Escudero, Jorge; Biagini, Simone Andrea, 1983-; García Calleja, Jorge; Moreno, Josep; Dobón Berenguer, Begoña, 1987-; Acosta, Sandra; Mondal, Mayukh, 1989-; Walsh Capdevila, Sandra, 1991-; Aguileta, Gabriela; Vallès, Mònica; Forrow, Stephen; Martín Caballero, Juan; Migliano, Andrea Bamberg; Bertranpetit, Jaume, 1952-; Muñoz López, Francisco José, 1964-; Bosch Fusté, Elena (Oxford University Press, 2024)
    Rainforest hunter-gatherers from Southeast Asia are characterized by specific morphological features including a particularly dark skin color (D), short stature (S), woolly hair (W), and the presence of steatopygia (S)-fat ...
  • Pacheco, Carla R.; Morales, Camila N.; Ramírez, Alejandra E.; Muñoz López, Francisco José, 1964-; Gallegos, Scarlet S.; Caviedes, Pablo A.; Aguayo, Luis G.; Opazo, Carlos M. (Wiley, 2015)
    It has been postulated that the accumulation of extracellular α-synuclein (α-syn) might alter the neuronal membrane by formation of 'pore-like structures' that will lead to alterations in ionic homeostasis. However, this ...
  • Ill-Raga, Gerard, 1982-; Palomer, Ernest; Ramos Fernández, Eva, 1984-; Guix Ràfols, Francesc Xavier; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Tajes Orduña, Marta; Valls Comamala, Victòria, 1987-; Jiménez Conde, Jordi; Ois Santiago, Angel Javier; Gil Gómez, Gabriel; Alameda Quitllet, Francisco; Roquer, Jaume; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Elsevier, 2015)
    Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its correct management. Ischemia produces increased nitric oxide ...
  • Picón-Pagès, Pol; Garcia Buendia, Joan; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood flow and also has important roles in intracellular signaling in neurons from the regulation of the neuronal metabolic status to ...
  • Ramos Fernández, Eva, 1984-; Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Vargas, Lina M.; Busquets Garcia, Arnau, 1985-; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Valls Comamala, Victòria, 1987-; Gomis González, Maria, 1988-; Grau, Cristina; Fandos, César; Rosen, Mark D.; Rabinowitz, Michael H.; Inestrosa, Nibaldo C.; Maldonado, Rafael, 1961-; Altafaj, Xavier; Ozaita Mintegui, Andrés, 1969-; Álvarez, Alejandra R.; Vicente García, Rubén, 1978-; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Impact Journals, 2016)
    The activation of N-Methyl D-Aspartate Receptor (NMDAR) by glutamate is crucial in the nervous system function, particularly in memory and learning. NMDAR is composed by two GluN1 and two GluN2 subunits. GluN2B has been ...
  • Picón-Pagès, Pol; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Garcia-Buendia, Joan; Gutierrez, Daniela; Valle, Javier; Gómez-Casuso, Carmen E.S.; Sidelkivska, Valeriya; Alvarez, Alejandra; Perálvarez Marín, Alex; Suades, Albert; Fernàndez Busquets, Xavier; Andreu Martínez, David; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate ...
  • Bosch Morató, Mònica, 1986-; Iriondo, Cinta; Guivernau Almazán, Biuse, 1988-; Valls Comamala, Victòria, 1987-; Vidal, Noemí; Olivé, Montse; Querfurth, Henry; Muñoz López, Francisco José, 1964- (Impact Journals, 2016)
    GNE myopathy is an autosomal recessive muscular disorder of young adults characterized by progressive skeletal muscle weakness and wasting. It is caused by a mutation in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine ...
  • Tajes Orduña, Marta; Eraso Pichot, Abel; Rubio Moscardó, Fanny; Guivernau Almazán, Biuse, 1988-; Ramos Fernández, Eva, 1984-; Bosch Morató, Mònica, 1986-; Guix Ràfols, Francesc Xavier; Clarimón Echevarría, Jordi; Miscione, Gian Pietro; Boada, Mercè; Gil Gómez, Gabriel; Suzuki, Toshiharu; Molina, Henrik; Villà i Freixa, Jordi; Vicente García, Rubén, 1978-; Muñoz López, Francisco José, 1964- (IOS Press, 2014)
    Amyloid-β peptide (Aβ) aggregates induce nitro-oxidative stress, contributing to the characteristic neurodegeneration found in Alzheimer's disease (AD). One of the most strongly nitrotyrosinated proteins in AD is the ...
  • Tajes Orduña, Marta; Eraso Pichot, Abel; Rubio Moscardó, Fanny; Guivernau Almazán, Biuse, 1988-; Bosch Morató, Mònica, 1986-; Valls Comamala, Victòria, 1987-; Miscione, Gian Pietro; Villà i Freixa, Jordi; Suzuki, Toshiharu; Muñoz López, Francisco José, 1964- (Elsevier, 2014)
    Alzheimer's disease (AD) is characterized by the oxidative stress generated from amyloid β-peptide (Aβ) aggregates. It produces protein nitrotyrosination, after the reaction with nitric oxide to form peroxynitrite, being ...

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