Browsing by Author "Muñoz Cánoves, Pura, 1962-"

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  • Aberrant repair and fibrosis development in skeletal muscle
    Mann, Christopher J.; Perdiguero, Eusebio, 1968-; Kharraz, Yacine; Aguilar, Susana; Pessina, Patrizia; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2011)
    The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells and resident stem ...
  • Aged stem cells reprogram their daily rhythmic functions to adapt to stress
    Solanas, Guiomar; Oliveira Peixoto, Francisca; Perdiguero, Eusebio, 1968-; Jardí, Mercè; Ruiz Bonilla, Vanesa, 1979-; Datta, Debayan; Symeonidi, Aikaterini; Castellanos, Andrés; Welz, Patrick-Simon; Martín Caballero, Juan; Sassone-Corsi, Paolo; Muñoz Cánoves, Pura, 1962-; Aznar Benitah, Salvador (Elsevier, 2017)
    Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain behaviorally circadian and that their ...
  • Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor
    Vidal Iglesias, Berta; Ardite, Esther; Suelves, Mònica; Ruiz Bonilla, Vanesa, 1979-; Janué, Anna; Flick, Matthew J.; Degen, Jay L.; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Oxford University Press, 2012)
    In Duchenne muscular dystrophy (DMD), a persistently altered and reorganizing extracellular matrix (ECM) within inflamed muscle promotes damage and dysfunction. However, the molecular determinants of the ECM that mediate ...
  • Assessing autophagy in muscle stem cells
    Campanario, Silvia; Ramírez Pardo, Ignacio; Hong, Xiaotong; Isern, Joan; Muñoz Cánoves, Pura, 1962- (Frontiers, 2021)
    The skeletal muscle tissue in the adult is relatively stable under normal conditions but retains a striking ability to regenerate by its resident stem cells (satellite cells). Satellite cells exist in a quiescent (G0) ...
  • Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscles
    Sreenivasan, Krishnamoorthy; Ianni, Alessandro; Künne, Carsten; Strilic, Boris; Günther, Stefan; Perdiguero, Eusebio, 1968-; Krüger, Marcus; Spuler, Simone; Offermanns, Stefan; Gómez del Arco, Pablo; Redondo, Juan Miguel; Muñoz Cánoves, Pura, 1962-; Kim, Johnny; Braun, Thomas (Elsevier, 2020)
    Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore ...
  • Autophagy: a decisive process for stemness
    García Prat, Laura; Martínez Vicente, Marta; Muñoz Cánoves, Pura, 1962- (Impact Journals, 2016)
    Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate ...
  • Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch
    López Arribillaga, Erika, 1986-; Rodilla, Verónica; Pellegrinet, Luca; Guiu Sagarra, Jordi, 1983-; Iglesias Coma, Mar; Roman, Angel Carlos; Gutarra, Susana; González, Susana; Muñoz Cánoves, Pura, 1962-; Fernández-Salguero, Pedro; Radtke, Freddy; Bigas Salvans, Anna; Espinosa Blay, Lluís (Company of Biologists, 2015)
    Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation ...
  • Cellular senescence in skeletal muscle regeneration, ageing and disease
    Moiseeva, Victoria, 1992- (Universitat Pompeu Fabra, 2022-07-21)
    Este proyecto se centra en el papel de las células senescentes durante la regeneración muscular desde varios ángulos. Para llevarlo a cabo, hemos desarrollado una técnica novedosa para poder aislar células senescentes ...
  • Cellular senescence is associated with human retinal microaneurysm formation during aging
    López-Luppo, Mariana; Catita, Joana; Ramos, David; Navarro, Marc; Carretero, Ana; Mendes Jorge, Luísa; Muñoz Cánoves, Pura, 1962-; Rodriguez-Baeza, Alfonso; Nacher, Víctor; Ruberte, Jesús (Association for Research in Vision and Ophthalmology (ARVO), 2017)
    Purpose: Microaneurysms are present in healthy old-age human retinas. However, to date, no age-related pathogenic mechanism has been implicated in their formation. Here, cellular senescence, a hallmark of aging and several ...
  • CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration
    Sreenivasan, Krishnamoorthy; Rodríguez de la Rosa, Alejandra; Kim, Johnny; Mesquita, Diana; Segalés Dalmau, Jessica; Gómez del Arco, Pablo; Espejo, Isabel; Ianni, Alessandro; Di Croce, Luciano; Relaix, Frederic; Redondo, Juan Miguel; Braun, Thomas; Serrano Sánchez, Antonio L.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Elsevier, 2021)
    Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is ...
  • Chromatin-wide and transcriptome profiling integration uncovers p38α MAPK as a global regulator of skeletal muscle differentiation
    Segalés Dalmau, Jessica; Islam, Abul, 1978-; Kumar, Roshan; Liu, Qi-Cai; Sousa-Victor, Pedro; Dilworth, F. Jeffrey; Ballestar, Esteban; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2016)
    Background: Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although ...
  • Cilia control fat deposition during tissue repair
    Perdiguero, Eusebio, 1968-; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Elsevier, 2017)
    Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the ...
  • Computational modelling of stem cell-niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing
    Potapov, Ilya; García Prat, Laura; Ravichandran, Srikanth; Muñoz Cánoves, Pura, 1962-; del Sol, Antonio (Wiley-Blackwell, 2022)
    The stem cell niche is a specialized microenvironment for stem cells in an adult tissue. The niche provides cues for the maintenance and regulation of stem cell activities and thus presents a target for potential rejuvenating ...
  • Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle
    Iavarone, Francescopaolo; Guardiola, Ombretta; Scagliola, Alessandra; Andolfi, Gennaro; Esposito, Federica; Serrano Sánchez, Antonio L.; Perdiguero, Eusebio, 1968-; Brunelli, Silvia; Muñoz Cánoves, Pura, 1962-; Minchiotti, Gabriella (EMBO Press, 2020)
    Macrophages are characterized by a high plasticity in response to changes in tissue microenvironment, which allows them to acquire different phenotypes and to exert essential functions in complex processes, such as tissue ...
  • Dual mTORC1/C2 inhibitors: gerosuppressors with potential anti-aging effect
    Sousa-Victor, Pedro; García-Prat, Laura, 1987-; Muñoz Cánoves, Pura, 1962- (Impact Journals, 2015)
    Over the past decade, our understanding of the molecular and cellular mechanisms presiding over cellular and tissue decline with aging has greatly advanced. Classical hallmarks of aging cell include increasing levels of ...
  • Editorial: role of stem cells in skeletal muscle development, regeneration, repair, aging, and disease
    Muñoz Cánoves, Pura, 1962-; Carvajal, Jaime J.; López de Munain, Adolfo; Izeta, Ander (Frontiers, 2016)
  • Expression and role of cyclin O in colorectal cancer
    Künnemann, Kathi, 1982- (Universitat Pompeu Fabra, 2013-09-13)
    Cyclin O, a novel identified Cdk1 and Cdk2-binding cyclin, has been demonstrated to be required for apoptosis induced by intrinsic apoptotic stimuli. Because proteins implicated in apoptosis are often deregulated in cancer, ...
  • Fibrogenic cell plasticity blunts tissue regeneration and aggravates muscular dystrophy
    Pessina, Patrizia; Kharraz, Yacine; Jardí, Mercè; Fukada, So-ichiro; Serrano, Antonio L.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Elsevier, 2015)
    Preservation of cell identity is necessary for homeostasis of most adult tissues. This process is challenged every time a tissue undergoes regeneration after stress or injury. In the lethal Duchenne muscular dystrophy ...
  • Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage
    Arc-Chagnaud, Coralie; Salvador-Pascual, Andrea; Garcia-Dominguez, Esther; Olaso-Gonzalez, Gloria; Correas, Angela G.; Serna, Eva; Brioche, Thomas; Chopard, Angele; Fernandez-Marcos, Pablo J.; Serrano, Manuel; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962-; Sebastiá, Vicente; Viña, Jose; Gomez-Cabrera, Mari Carmen (Wiley, 2021)
    Background: Frailty is a major age-associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine ...
  • Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages
    Prados, Belén; Del Toro, Raquel; MacGrogan, Donal; Gómez Apiñániz, Paula; Papoutsi, Tania; Muñoz Cánoves, Pura, 1962-; Méndez Ferrer, Simón; de la Pompa, José Luis (Nature Research, 2021)
    Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic ...