Browsing by Author "Morales Pastor, Adrián"

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  • Morales Pastor, Adrián (Universitat Pompeu Fabra, 2024-04-16)
    G protein-coupled receptors (GPCRs) are central to cellular signaling and pivotal in drug development. This thesis investigates allosteric communication in GPCRs, crucial for their effective modulation in pharmacotherapy. ...
  • Torrens Fontanals, Mariona; Stepniewski, Tomasz Maciej, 1988-; Aranda García, David; Morales Pastor, Adrián; Medel Lacruz, Brian; Selent, Jana (MDPI, 2020)
    G protein-coupled receptors (GPCRs) are implicated in nearly every physiological process in the human body and therefore represent an important drug targeting class. Advances in X-ray crystallography and cryo-electron ...
  • Morales Pastor, Adrián; Nerín-Fonz, Francho; Aranda García, David; Dieguez-Eceolaza, Miguel; Medel Lacruz, Brian; Torrens Fontanals, Mariona; Peralta-Garcia, Alejandro; Selent, Jana (MDPI, 2002)
    Signaling bias is a promising characteristic of G protein-coupled receptors (GPCRs) as it provides the opportunity to develop more efficacious and safer drugs. This is because biased ligands can avoid the activation of ...

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