Browsing by Author "Monti, Michele"

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  • Milanetti, Edoardo; Miotto, Mattia; Di Rienzo, Lorenzo; Monti, Michele; Gosti, Giorgio; Ruocco, Giancarlo (Elsevier, 2020)
    We present a method for efficiently and effectively assessing whether and where two proteins can interact with each other to form a complex. This is still largely an open problem, even for those relatively few cases where ...
  • Monti, Michele; Armaos, Alexandros, 1989-; Fantini, Marco; Pastore, Annalisa; Tartaglia, Gian Gaetano (Frontiers, 2021)
    Solubility is a requirement for many cellular processes. Loss of solubility and aggregation can lead to the partial or complete abrogation of protein function. Thus, understanding the relationship between protein evolution ...
  • Milanetti, Edoardo; Miotto, Mattia; Di Rienzo, Lorenzo; Nagaraj, Madhu; Monti, Michele; Golbek, Thaddeus W.; Gosti, Giorgio; Roeters, Steven J.; Weidner, Tobias; Otzen, Daniel E.; Ruocco, Giancarlo (Frontiers, 2021)
    We propose a computational investigation on the interaction mechanisms between SARS-CoV-2 spike protein and possible human cell receptors. In particular, we make use of our newly developed numerical method able to determine ...
  • Monti, Michele; Guiducci, Giulia; Paone, Alessio; Rinaldo, Serena; Giardina, Giorgio; Liberati, Francesca Romana; Cutruzzolá, Francesca; Tartaglia, Gian Gaetano (Elsevier, 2021)
    Human serine hydroxymethyltransferase (SHMT) regulates the serine-glycine one carbon metabolism and plays a role in cancer metabolic reprogramming. Two SHMT isozymes are acting in the cell: SHMT1 encoding the cytoplasmic ...
  • Monti, Michele; Fiorentino, Jonathan; Milanetti, Edoardo; Gosti, Giorgio; Tartaglia, Gian Gaetano (MDPI, 2022)
    Methods for time series prediction and classification of gene regulatory networks (GRNs) from gene expression data have been treated separately so far. The recent emergence of attention-based recurrent neural network (RNN) ...
  • Vandelli, Andrea; Monti, Michele; Milanetti, Edoardo; Armaos, Alexandros, 1989-; Rupert, Jakob; Zacco, Elsa; Bechara, Elias; Delli Ponti, Riccardo, 1987-; Tartaglia, Gian Gaetano (Oxford University Press, 2020)
    Specific elements of viral genomes regulate interactions within host cells. Here, we calculated the secondary structure content of >2000 coronaviruses and computed >100 000 human protein interactions with severe acute ...