Browsing by Author "Montanucci, Ludovica, 1978-"

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  • A system-level, molecular evolutionary analysis of mammalian phototransduction
    Invergo, Brandon M., 1982-; Montanucci, Ludovica, 1978-; Laayouni, Hafid, 1968-; Bertranpetit, Jaume, 1952- (BioMed Central, 2013)
    Visual perception is initiated in the photoreceptor cells of the retina via the phototransduction system./nThis system has shown marked evolution during mammalian divergence in such complex attributes as activation time ...
  • A system-level, molecular evolutionary analysis of mammalian phototransduction
    Invergo, Brandon M., 1982- (Universitat Pompeu Fabra, 2013-11-22)
    Phototransduction is the biochemical process by which a light stimulus is converted to a neuronal signal. The process functions through complex interactions between many proteins, which work in concert to tightly control ...
  • A comprehensive model of the phototransduction cascade in mouse rod cells
    Invergo, Brandon M., 1982-; Dell'Orco, Daniele; Montanucci, Ludovica, 1978-; Koch, Karl-Wilhelm; Bertranpetit, Jaume, 1952- (Royal Society of Chemistry, 2014)
    Vertebrate visual phototransduction is perhaps the most well-studied G-protein signaling pathway. A wealth of available biochemical and electrophysiological data has resulted in a rich history of mathematical modeling of ...
  • Distribution of events of positive selection and population differentiation in a metabolic pathway: the case of asparagine N-glycosylation
    Dall'Olio, Giovanni Marco, 1983-; Laayouni, Hafid, 1968-; Luisi, Pierre, 1985-; Sikora, Martin, 1976-; Montanucci, Ludovica, 1978-; Bertranpetit, Jaume, 1952- (BioMed Central, 2012)
    Asparagine N-Glycosylation is one of the most important forms of protein post-translational modification in eukaryotes. This metabolic pathway can be subdivided into two parts: an upstream sub-pathway required for achieving ...
  • Dynamic sensitivity and nonlinear interactions influence the system-level evolutionary patterns of phototransduction proteins
    Invergo, Brandon M., 1982-; Montanucci, Ludovica, 1978-; Bertranpetit, Jaume, 1952- (Royal Society, 2015)
    Determining the influence of complex, molecular-system dynamics on the evolution of proteins is hindered by the significant challenge of quantifying the control exerted by the proteins on system output. We have employed a ...
  • Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling
    Invergo, Brandon M., 1982-; Montanucci, Ludovica, 1978-; Koch, Karl-Wilhelm; Bertranpetit, Jaume, 1952-; Dell'Orco, Daniele (BioMed Central, 2013)
    Phototransduction in vertebrate photoreceptor cells represents a paradigm of signaling pathways mediated by G-protein-coupled receptors (GPCRs), which share common modules linking the initiation of the cascade to the final ...
  • Gene connectivity and enzyme evolution in the human metabolic network
    Dobón Berenguer, Begoña, 1987-; Montanucci, Ludovica, 1978-; Peretó, Juli; Bertranpetit, Jaume, 1952-; Laayouni, Hafid, 1968- (BioMed Central, 2019)
    Background: Determining the factors involved in the likelihood of a gene being under adaptive selection is still a challenging goal in Evolutionary Biology. Here, we perform an evolutionary analysis of the human metabolic ...
  • Genetic adaptation of the antibacterial human innate immunity network
    Casals López, Ferran; Sikora, Martin, 1976-; Laayouni, Hafid, 1968-; Montanucci, Ludovica, 1978-; Muntasell i Castellví, Aura, 1972-; Lazarus, Ross; Calafell i Majó, Francesc; Awadalla, Philip; Netea, Mihai G; Bertranpetit, Jaume, 1952- (BioMed Central, 2011)
    Background: Pathogens have represented an important selective force during the adaptation of modern human populations to changing social and other environmental conditions. The evolution of the immune system has therefore ...
  • Influence of pathway topology and functional class on the molecular evolution of human metabolic genes
    Montanucci, Ludovica, 1978-; Laayouni, Hafid, 1968-; Dobón Berenguer, Begoña, 1987-; Keys, Kevin L.; Bertranpetit, Jaume, 1952-; Peretó, Juli (Public Library of Science (PLoS), 2018)
    Metabolic networks comprise thousands of enzymatic reactions functioning in a controlled manner and have been shaped by natural selection. Thanks to the genome data, the footprints of adaptive (positive) selection are ...
  • Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes
    Colombo, Martino; Laayouni, Hafid, 1968-; Invergo, Brandon M., 1982-; Bertranpetit, Jaume, 1952-; Montanucci, Ludovica, 1978- (Wiley-VCH Verlag, 2014)
    Relationships between evolutionary rates and gene properties on a genomic, functional, pathway, or system level are being explored to unravel the principles of the evolutionary process. In particular, functional network ...
  • Similarity in recombination rate estimates highly correlates with genetic differentiation in humans
    Laayouni, Hafid, 1968-; Montanucci, Ludovica, 1978-; Sikora, Martin, 1976-; Melé Messeguer, Marta, 1982-; Dall'Olio, Giovanni Marco, 1983-; Lorente-Galdós, Belén, 1981-; McGee, Kate M; Graffelman, Jan; Awadalla, Philip; Bosch Fusté, Elena; Comas, David, 1969-; Navarro i Cuartiellas, Arcadi, 1969-; Calafell i Majó, Francesc; Casals López, Ferran; Bertranpetit, Jaume, 1952- (Public Library of Science (PLoS), 2011)
    Recombination varies greatly among species, as illustrated by the poor conservation of the recombination landscape between humans and chimpanzees. Thus, shorter evolutionary time frames are needed to understand the evolution ...