Addiction involves long-lasting maladaptive changes including development of disruptive drug-stimuli associations. Nicotine-induced neuroplasticity underlies the development of tobacco addiction but also, in regions such ...
The CHRNA5/A3/B4 genomic cluster encodes for the alpha5, alpha3 and beta4
subunits of the nicotinic acetylcholine receptors (nAChRs). Human genetic studies have
revealed a significant association of variants in this genomic ...
Recent studies have revealed that sequence variants in genes encoding the α3/α5/β4 nicotinic acetylcholine receptor subunits are associated with nicotine dependence. In this study, we evaluated two specific aspects of ...
Abuse of alcohol and smoking are extensively co-morbid. Some studies suggest partial commonality of action of alcohol and nicotine mediated through nicotinic acetylcholine receptors (nAChRs). We tested mice with transgenic ...
