Browsing by Author "Minoche, André E."

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  • Architecture and evolution of a minute plant genome
    Ibarra-Laclette, Enrique; Himmelbauer, Heinz; Minoche, André E.; Herrera-Estrella, Luis (Springer, 2013)
    It has been argued that the evolution of plant genome size is principally unidirectional and increasing owing to the varied action of whole-genome duplications (WGDs) and mobile element proliferation1. However, extreme ...
  • Crop wild relative populations of Beta vulgaris allow direct mapping of agronomically important genes
    Capistrano-Gossmann, Gina G.; Ries, David; Holtgräwe, Daniela; Minoche, André E.; Kraft, Thomas; Frerichmann, Sebastian L.M.; Rosleff Soerensen, T.; Dohm, Juliane C.; González Navarrete, Irene, 1983-; Schilhabel, Markus B.; Varrelmann, Mark; Tschoep, Hendrik; Uphoff, Hubert; Schütze, Katia; Borchardt, Dietrich C.; Toerjek, O.; Mechelke, Wolfgang; Lein, Jens Christoph; Schechert, Axel W.; Frese, Lothar; Himmelbauer, Heinz; Weisshaar, Bernd; Kopisch-Obuch, Friedrich J. (Nature Publishing Group, 2017)
    Rapid identification of agronomically important genes is of pivotal interest for crop breeding. One source of such genes are crop wild relative (CWR) populations. Here we used a CWR population of <200 wild beets (B. vulgaris ...
  • Exploiting single-molecule transcript sequencing for eukaryotic gene prediction
    Minoche, André E.; Dohm, Juliane C.; Schneider, Jessica; Holtgräwe, Daniela; Viehöver, Prisca; Montfort, Magda; Sörensen, Thomas Rosleff; Weisshaar, Bernd; Himmelbauer, Heinz (BioMed Central, 2015)
    We develop a method to predict and validate gene models using PacBio single-molecule, real-time (SMRT) cDNA reads. Ninety-eight percent of full-insert SMRT reads span complete open reading frames. Gene model validation ...
  • Identification of ALK gene alterations in urothelial carcinoma
    Bellmunt Molins, Joaquim, 1959-; Selvarajah, Shamini; Rodig, Scott; Salido Galeote, Marta; Muga, Silvia de; Costa, Irmgard; Bellosillo Paricio, Beatriz; Werner, Lillian; Mullane, Stephanie A.; Fay, André P.; O’Brien, Robert; Barretina, Jordi; Minoche, André E.; Signoretti, Sabina; Montagut Viladot, Clara; Himmelbauer, Heinz; Berman, David M.; Kantoff, Philip; Choueiri, Toni K.; Rosenberg, Jonathan E. (Public Library of Science (PLoS), 2014)
    Anaplastic lymphoma kinase (ALK) genomic alterations have emerged as a potent predictor of benefit from treatment with ALK inhibitors in several cancers. Currently, there is no information about ALK gene alterations in ...
  • Molecular signatures of plastic phenotypes in two eusocial insect species with simple societies
    Solenn, Patalano; Vlasova, Anna; Wyatt, Christopher Douglas Robert, 1988-; Cámara, Francisco; Pedro G., Ferreira; González, Irene; Minoche, André E.; Lowy Gallego, Ernesto; Marcet Houben, Marina; Rodríguez Ales, José Luis; Gabaldón Estevan, Juan Antonio, 1973-; Himmelbauer, Heinz; Guigó Serra, Roderic; Sumner, Seirian (National Academy of Sciences, 2015)
    Phenotypic plasticity is important in adaptation and shapes the evolution of organisms. However, we understand little about what aspects of the genome are important in facilitating plasticity. Eusocial insect societies ...
  • The genome of the recently domesticated crop plant sugar beet (Beta vulgaris)
    Dohm, Juliane C.; Minoche, André E.; Holtgräwe, Daniela; Capella Gutiérrez, Salvador Jesús, 1985-; Zakrzewski, Falk; Tafer, Hakim; Rupp, Oliver; Sörensen, Thomas Rosleff; Stracke, Ralf; Reinhardt, Richard; Goesmann, Alexander; Kraft, Thomas; Schulz, Britta; Stadler, Peter F.; Schmidt, Thomas; Gabaldón Estevan, Juan Antonio, 1973-; Lehrach, Hans; Weisshaar, Bernd; Himmelbauer, Heinz (Nature Publishing Group, 2014)
    Sugar beet (Beta vulgaris ssp. vulgaris) is an important crop of temperate climates which provides nearly 30% of the world's annual sugar production and is a source for bioethanol and animal feed. The species belongs to ...
  • Yield of clinically reportable genetic variants in unselected cerebral palsy by whole genome sequencing
    van Eyk, Clare L.; Webber, Dani L.; Minoche, André E.; Pérez Jurado, Luis Alberto; Corbett, Mark A.; Gardner, Alison E.; Berry, Jesia G.; Harper, Kelly; MacLennan, Alastair H.; Gecz, Jozef (Nature Research, 2021)
    Cerebral palsy (CP) is the most common cause of childhood physical disability, with incidence between 1/500 and 1/700 births in the developed world. Despite increasing evidence for a major contribution of genetics to CP ...

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