Browsing by Author "Minguillón, Carolina"

Sort by: Order: Results:

  • A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease
    González Ortiz, Fernando; González Escalante, Armand; Ortiz Romero, Paula, 1994-; Minguillón, Carolina; Contador, Jose; Suárez-Calvet, Marc; Blennow, Kaj (Elsevier, 2024)
    Introduction: Detection of Alzheimer's disease (AD) pathophysiology among individuals with mild cognitive changes and those experiencing subjective cognitive decline (SCD) remains challenging. Plasma phosphorylated tau 217 ...
  • Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
    Milà Alomà, Marta; Salvadó, Gemma; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; Arenaza Urquijo, Eider M.; Crous-Bou, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    Introduction: The biological pathways involved in the preclinical stage of the Alzheimer's continuum are not well understood. Methods: We used NeuroToolKit and Elecsys® immunoassays to measure cerebrospinal fluid (CSF) ...
  • Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume
    Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Operto, Grégory; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Sala Vila, Aleix; Crous-Bou, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Molinuevo, José Luis; ALFA Study (Elsevier, 2021)
    Neurofilament light chain (NfL) is an axonal protein that when measured in cerebrospinal fluid (CSF) serves as a biomarker of neurodegeneration. We aimed at investigating the association among CSF NfL, presence of Subjective ...
  • Analysis of psychological symptoms following disclosure of amyloid-positron emission tomography imaging results to adults with subjective cognitive decline
    Caprioglio, Camilla; Minguillón, Carolina; Grau-Rivera, Oriol; Molinuevo, José Luis; Gispert López, Juan Domingo; AMYPAD Consortium (American Medical Association, 2023)
    Importance Individuals who are amyloid-positive with subjective cognitive decline and clinical features increasing the likelihood of preclinical Alzheimer disease (SCD+) are at higher risk of developing dementia. Some ...
  • APOE-ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals
    Brugulat Serrat, Anna, 1986-; Sánchez Benavides, Gonzalo; Cacciaglia, Raffaele; Shekari, Mahnaz; Milà Alomà, Marta; Vilor Tejedor, Natàlia, 1988-; Operto, Grégory; Falcón, Carles; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; Minguillón, Carolina; Fauria, Karine; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (Springer, 2023)
    Purpose: To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants. Methods: The 352 CU ...
  • Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults
    Grau-Rivera, Oriol; Operto, Grégory; Falcón, Carles; Sánchez Benavides, Gonzalo; Cacciaglia, Raffaele; Brugulat Serrat, Anna, 1986-; Gramunt Fombuena, Nina; Salvadó, Gemma; Suárez-Calvet, Marc; Minguillón, Carolina; Iranzo, Alex; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2020)
    Background: Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study aims were to characterize ...
  • Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease
    Rodríguez-Fernández, Blanca; Sánchez Benavides, Gonzalo; Genius, Patricia; Minguillón, Carolina; Fauria, Karine; De Vivo, Immaculata; Navarro i Cuartiellas, Arcadi, 1969-; Molinuevo, José Luis; Gispert López, Juan Domingo; Sala Vila, Aleix; Vilor Tejedor, Natàlia, 1988-; Crous-Bou, Marta; ALFA Study (Elsevier, 2024)
    Introduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association ...
  • Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer's disease
    Grau-Rivera, Oriol; Navalpotro-Gómez, Irene; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Salvadó, Gemma; Sala Vila, Aleix; Shekari, Mahnaz; González de Echávarri, José Maria; Minguillón, Carolina; Niñerola-Baizán, Aida; Perissinotti, Andrés; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Recognizing clinical manifestations heralding the development of Alzheimer's disease (AD)-related cognitive impairment could improve the identification of individuals at higher risk of AD who may benefit from ...
  • Associations between air pollution and biomarkers of Alzheimer's disease in cognitively unimpaired individuals
    Alemany, Silvia; Vilor Tejedor, Natàlia, 1988-; Milà Alomà, Marta; Suárez-Calvet, Marc; Salvadó, Gemma; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Grau-Rivera, Oriol; Minguillón, Carolina; Fauria, Karine; Domingo Gispert, Juan; Gascon Merlos, Mireia, 1984-; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi; ALFA Study (Elsevier, 2021)
    Background: Air quality contributes to incidence of Alzheimer's disease (AD) although the underlying neurobiological mechanisms are unclear. This study was aimed to examine the association between air pollution and ...
  • Astrocyte biomarkers GFAP and YKL-40 mediate early Alzheimer's disease progression
    Pelkmans, Wiesje; Shekari, Mahnaz; Brugulat Serrat, Anna, 1986-; Sánchez Benavides, Gonzalo; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Grau-Rivera, Oriol; González Escalante, Armand; Kollmorgen, Gwendlyn; Carboni, Margherita; Ashton, Nicholas J.; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (Wiley, 2024)
    Introduction: We studied how biomarkers of reactive astrogliosis mediate the pathogenic cascade in the earliest Alzheimer's disease (AD) stages. Methods: We performed path analysis on data from 384 cognitively unimpaired ...
  • Atypical cortical hierarchy in Aβ-positive older adults and its reflection in spontaneous speech
    He, Rui; Al-Tamimi, Jalal; Sánchez Benavides, Gonzalo; Montaña Valverde, Guillermo; Gispert López, Juan Domingo; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Minguillón, Carolina; Fauria, Karine; Navarro i Cuartiellas, Arcadi, 1969-; Hinzen, Wolfram (Elsevier, 2024)
    Abnormal deposition of Aβ amyloid is an early neuropathological marker of Alzheimer's disease (AD), arising long ahead of clinical symptoms. Non-invasive measures of associated early neurofunctional changes, together with ...
  • Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer's disease and neurodegeneration stratified by sex
    Cumplido-Mayoral, Irene; Operto, Grégory; Falcón, Carles; Shekari, Mahnaz; Cacciaglia, Raffaele; Milà Alomà, Marta; Minguillón, Carolina; Suárez-Calvet, Marc; Gispert López, Juan Domingo; OASIS study (eLife, 2023)
    Brain-age can be inferred from structural neuroimaging and compared to chronological age (brain-age delta) as a marker of biological brain aging. Accelerated aging has been found in neurodegenerative disorders like Alzheimer's ...
  • Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers
    Salvadó, Gemma; Molinuevo, José Luis; Brugulat Serrat, Anna, 1986-; Falcón, Carles; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Pavía Segura, Javier; Niñerola-Baizán, Aida; Perissinotti, Andrés; Lomeña, Francisco; Minguillón, Carolina; Fauria, Karine; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative (BioMed Central, 2019)
    Background: The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making for ...
  • Cerebral amyloid-β load is associated with neurodegeneration and gliosis: Mediation by p-tau and interactions with risk factors early in the Alzheimer's continuum
    Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Buckley, Christopher, 1948-; Farrar, Gill; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2021)
    Introduction: The association between cerebral amyloid-β accumulation and downstream CSF biomarkers is not fully understood, particularly in asymptomatic stages. Methods: In 318 cognitively unimpaired participants, we ...
  • Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile
    Milà Alomà, Marta; Shekari, Mahnaz; Salvadó, Gemma; Gispert López, Juan Domingo; Arenaza Urquijo, Eider M.; Operto, Grégory; Falcón, Carles; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer's continuum is crucial to develop therapeutic and preventive strategies. The ...
  • CSF glial biomarkers are associated with cognition in individuals at risk of Alzheimer's disease
    Warmenhoven, Noëlle; Sánchez Benavides, Gonzalo; González Escalante, Armand; Milà Alomà, Marta; Shekari, Mahnaz; López Martos, David; Ortiz Romero, Paula, 1994-; Kollmorgen, Gwendlyn; Quijano Rubio, Clara; Minguillón, Carolina; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Palpatzis, Eleni; Ashton, Nicholas J.; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Grau-Rivera, Oriol; ALFA Study (Wiley, 2024)
    Introduction: We examined whether baseline glial markers soluble triggering receptor expressed on myeloid cell 2 (sTREM2), chitinase 3-like protein 1 (YKL-40), and glial fibrillary acidic protein (GFAP) in cerebrospinal ...
  • CSF synaptic biomarkers in the preclinical stage of Alzheimer disease and their association with MRI and PET: a cross-sectional study
    Milà Alomà, Marta; Brinkmalm, Ann; Ashton, Nicholas J.; Kvartsberg, Hlin; Shekari, Mahnaz; Operto, Grégory; Salvadó, Gemma; Falcon, Carles; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Sala Vila, Aleix; Sanchez-Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Molinuevo, José Luis; Blennow, Kaj; Suárez-Calvet, Marc; ALFA Study (Lippincott Williams & Wilkins, 2021)
    Background and objectives: To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of the Alzheimer continuum and associated with Alzheimer disease (AD) risk factors, primary pathology, and ...
  • Dementia prevention in memory clinics: recommendations from the European task force for brain health services
    Frisoni, Giovanni B.; Minguillón, Carolina; Dubois, Bruno (Elsevier, 2023)
    Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging ...
  • Dementia risk communication. A user manual for brain health Services-part 3 of 6
    Visser Leonie N.C.; Minguillón, Carolina; Sánchez Benavides, Gonzalo; Abramowicz, Marc; Altomare, Daniele; Fauria, Karine; Frisoni, Giovanni B.; Georges, Jean; Ribaldi, Federica; Scheltens, Philip; Jetsk van der Schaar, Philip; Zwan, Marissa; van der Flier, Wiesje M.; Molinuevo, José Luis (BioMed Central, 2021)
    Growing evidence suggests dementia incidence can be reduced through prevention programs targeting risk factors. To accelerate the implementation of such prevention programs, a new generation of brain health services (BHS) ...
  • Description of a European memory clinic cohort undergoing amyloid-PET: the AMYPAD diagnostic and patient management study
    Altomare, Daniele; Grau-Rivera, Oriol; Gispert López, Juan Domingo; Minguillón, Carolina; Frisoni, Giovanni B.; AMYPAD Consortium (Wiley, 2022)
    Introduction: AMYPAD Diagnostic and Patient Management Study (DPMS) aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Here we present participants' baseline features and discuss the ...

Search DSpace

Browse

My Account

In collaboration with Compliant to Partaking