Browsing by Author "Merkel, Angelika"

Sort by: Order: Results:

  • Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time
    Feichtinger, Julia; Hernández, Inmaculada; Fischer, Christoph; Hanscho, Michael; Auer, Norbert; Hackl, Matthias; Jadhav, Vaibhav; Baumann, Martina; Krempl, Peter M.; Schmidl, Christian; Farlik, Matthias; Schuster, Michael; Merkel, Angelika; Sommer, Andreas; Heath, Simon; Rico, Daniel; Bock, Christoph; Thallinger, Gerhard R.; Borth, Nicole (Wiley, 2016)
    The most striking characteristic of CHO cells is their adaptability, which enables efficient production of proteins as well as growth under a variety of culture conditions, but also results in genomic and phenotypic ...
  • Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems
    Schuyler, Ronald P.; Merkel, Angelika; Raineri, Emanuele; Gut, Ivo Glynne; Heath, Simon (Elsevier, 2016)
    DNA methylation and the localization and post-translational modification of nucleosomes are interdependent factors that contribute to the generation of distinct phenotypes from genetically identical cells. With 112 ...
  • Dynamics of transcription regulation in human bone marrow myeloid differentiation to mature blood neutrophils
    Grassi, Luigi; Ullrich, Sebastian, 1984-; Merkel, Angelika; Gut, Marta; Heath, Simon; Gut, Ivo Glynne; Kuijpers, Taco W. (Elsevier, 2018)
    Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing ...
  • Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation
    Arribas, Víctor; Onetti, Yara; Ramiro Pareta, Marina; Villacampa, Pilar; Beck, Heike; Alberola i Pla, Mariona; Esteve-Codina, Anna; Merkel, Angelika; Sperandio, Markus; Martínez Estrada, Ofelia M.; Schmid, Bettina; Montanez, Eloi (American Society for Clinical Investigation, 2024)
    TAR DNA-binding protein 43 (TDP-43) is a DNA/RNA-binding protein that regulates gene expression, and its malfunction in neurons has been causally associated with multiple neurodegenerative disorders. Although progress has ...
  • Epigenetic regulation of gene expression in Chinese hamster ovary cells in response to the changing environment of a batch culture
    Hernandez, Inmaculada; Dhiman, Heena; Klanert, Gerald; Jadhav, Vaibhav; Auer, Norbert; Hanscho, Michael; Baumann, Martina; Esteve-Codina, Anna; Dabad, Marc; Gómez, Jessica; Alioto, Tyler; Merkel, Angelika; Raineri, Emanuele; Heath, Simon; Rico, Daniel; Borth, Nicole (Wiley, 2019)
    The existence of dynamic cellular phenotypes in changing environmental conditions is of major interest for cell biologists who aim to understand the mechanism and sequence of regulation of gene expression. In the context ...
  • gemBS: high throughput processing for DNA methylation data from bisulfite sequencing
    Merkel, Angelika; Fernández Callejo, Marcos; Casals, Eloi; Marco Sola, Santiago; Schuyler, Ronald P.; Gut, Ivo Glynne; Heath, Simon (Oxford University Press, 2019)
    Motivation: DNA methylation is essential for normal embryogenesis and development in mammals and can be captured at single base pair resolution by whole genome bisulfite sequencing (WGBS). Current available analysis tools ...
  • Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types
    Ecker, Simone; Merkel, Angelika; BLUEPRINT Consortium; Paul, Dirk S. (BioMed Central, 2017)
    Background: A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. Results: We apply a novel ...
  • Grape RNA-Seq analysis pipeline environment
    Knowles, David G.; Röder, Maik; Merkel, Angelika; Guigó Serra, Roderic (Oxford University Press, 2013)
    MOTIVATION: The avalanche of data arriving since the development of NGS technologies have prompted the need for developing fast, accurate and easily automated bioinformatic tools capable of dealing with massive datasets. ...
  • Landscape of transcription in human cells
    Djebali, Sarah; Merkel, Angelika; Tanzer, Andrea; Lagarde, Julien; Röder, Maik; Curado, Joao; Derrien, Thomas; Ferreira, Pedro G.; González, David; Johnson, Rory; Kingswood, Colin; Ribeca, Paolo; Sammeth, Michael; Skancke, Jorgen; Tilgner, Hagen, 1980-; Guigó Serra, Roderic; Gingeras, Thomas R. (Nature Publishing Group, 2012)
    Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic ...
  • The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression
    Derrien, Thomas; Johnson, Rory; Bussotti, Giovanni, 1983-; Tanzer, Andrea; Djebali, Sarah; Tilgner, Hagen, 1980-; Guernec, Gregory; Martin, David; Merkel, Angelika; Knowles, David G.; Lagarde, Julien; Veeravalli, Lavanya; Ruan, Xiaoan; Ruan, Yijun; Lassmann, Timo; Carninci, Piero; Brown, James B.; Lipovich, Leonard; González, José M.; Thomas, Mark; Davis, Carrie A.; Shiekhattar, Ramin; Gingeras, Thomas R.; Hubbard, Tim J.; Notredame, Cedric; Harrow, Jennifer; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    The human genome contains many thousands of long noncoding RNAs (lncRNAs). While several studies have demonstrated compelling biological and disease roles for individual examples, analytical and experimental approaches to ...
  • Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson's disease patients
    Fernández-Santiago, Ruben; Merkel, Angelika; Castellano, Giancarlo; Heath, Simon; Raya Chamorro, Ángel; Tolosa, Eduard; Martí, Maria José; Consiglio, Antonella; Ezquerra, Mario (BioMed Central, 2019)
    Background: Parkinson’s disease (PD) is characterized by the loss of midbrain dopaminergic neurons (DAn). Previously, we described the presence of DNA hyper- and hypo-methylation alterations in induced pluripotent stem ...

Search DSpace

Browse

My Account

In collaboration with Compliant to Partaking