Listar por autoría "Melén, Erik"

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  • Air pollution and IgE sensitization in 4 European birth cohorts-the MeDALL project
    Melén, Erik; Antó i Boqué, Josep Maria; Gruzieva, Olena (Elsevier, 2021)
    Background: Whether long-term exposure air to pollution has effects on allergic sensitization is controversial. Objective: Our aim was to investigate associations of air pollution exposure at birth and at the time of later ...
  • Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence
    Wickman, Magnus; Lupinek, Christian; Andersson, Niklas; Belgrave, Danielle; Asarnoj, Anna; Benet, Marta; Pinart, Mariona; Wieser, Sandra; García Aymerich, Judith; Baar, Alexandra; Pershagen, Göran; Simpson, Angela; Kull, Inger; Bergström, Anna; Melén, Erik; Hamsten, Carl; Antó i Boqué, Josep Maria; Bousquet, Jean; Custovic, Adnan; Valenta, Rudolf; van Hage, Marianne (Elsevier, 2017)
    BACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random ...
  • Developing the building blocks to elucidate the impact of the urban exposome on cardiometabolic-pulmonary disease: The EU EXPANSE project
    Vlaanderen, Jelle; de Hoogh, Kees; Hoek, Gerard; Peters, Annette; Probst-Hensch, Nicole; Scalbert, Augustin; Melén, Erik; Tonne, Cathryn; de Wit, G. Ardine; Chadeau-Hyam, Marc; Katsouyanni, Klea; Esko, Tõnu; Jongsma, Karin R.; Vermeulen, Roel (Wolters Kluwer (LWW), 2021)
    By 2030, more than 80% of Europe's population will live in an urban environment. The urban exposome, consisting of factors such as where we live and work, where and what we eat, our social network, and what chemical and ...
  • Distinction between rhinitis alone and rhinitis with asthma using interactomics
    Aguilar, Daniel; Lemonnier, Nathanael; Melén, Erik; Bustamante Pineda, Mariona; Gruzieva, Olena; Guerra, Stefano; Keil, Thomas; Koppelman, Gerard H.; Celedón, Juan C.; Antó i Boqué, Josep Maria; Bousquet, Jean (Nature Research, 2023)
    The concept of "one-airway-one-disease", coined over 20 years ago, may be an over-simplification of the links between allergic diseases. Genomic studies suggest that rhinitis alone and rhinitis with asthma are operated by ...
  • Effect of residential relocation on environmental exposures in European cohorts: an exposome-wide approach
    Saucy, Apolline; Gehring, Ulrike; Olmos, Sergio; Delpierre, Cyrille; De Bont, Jeroen, 1989-; Gruzieva, Olena; de Hoogh, Kees; Huss, Anke; Ljungman, Petter; Melén, Erik; Persson, Åsa; Pieterson, Inka; Tewis, Marjan; Yu, Zhebin; Vermeulen, Roel; Vlaanderen, Jelle; Tonne, Cathryn (Elsevier, 2023)
    Residential relocation is increasingly used as a natural experiment in epidemiological studies to assess the health impact of changes in environmental exposures. Since the likelihood of relocation can be influenced by ...
  • Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
    Merid, Simon Kebede; Kogevinas, Manolis; Bustamante Pineda, Mariona; Vrijheid, Martine; Sunyer Deu, Jordi; Antó i Boqué, Josep Maria; Melén, Erik (BioMed Central, 2020)
    Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ...
  • Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure
    Gruzieva, Olena; Antó i Boqué, Josep Maria; Bustamante Pineda, Mariona; Guxens Junyent, Mònica; Sunyer Deu, Jordi; Melén, Erik (Environmental health perspectives, 2017)
    BACKGROUND: Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation. OBJECTIVES: We investigated associations ...
  • Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure
    Merid, Simon Kebede; Bustamante Pineda, Mariona; Standl, Marie; Sunyer Deu, Jordi; Heinrich, Joachim; Lemonnier, Nathanael; Aguilar, Daniel; Antó i Boqué, Josep Maria; Bousquet, Jean; Santa Marina, Loreto; Lertxundi, Aitana; Bergström, Anna; Kull, Inger; Wheelock, Åsa M.; Koppelman, Gerard H.; Melén, Erik; Gruzieva, Olena (Elsevier, 2020)
    Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ...
  • Mixtures of long-term exposure to ambient air pollution, built environment and temperature and stroke incidence across Europe
    Bont, Jeroen de; Pickford, Regina; Astrom, Christopher; Colomar, Fabian; Dimakopoulou, Konstantina; Hoogh, Kees de; Ibi, Dorina; Katsouyanni, Klea; Melén, Erik; Nobile, Federica; Pershagen, Göran; Persson, Åsa; Samoli, Evangelia; Stafoggia, Massimo; Tonne, Cathryn; Vlaanderen, Jelle; Wolf, Kathrin; Vermeulen, Roel; Peters, Annette; Ljungman, Petter (Elsevier, 2023)
    Introduction: The complex interplay of multiple environmental factors and cardiovascular has scarcely been studied. Within the EXPANSE project, we evaluated the association between long-term exposure to multiple environmental ...
  • Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story
    Bousquet, Jean; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; Melén, Erik; Benet, Marta; Basagaña Flores, Xavier; Torrent Quetglas, Maties; Xu, Cheng-Jian (Wiley, 2016)
    MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for ...
  • Phenotyping asthma, rhinitis, and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster
    García Aymerich, Judith; Benet, Marta; Saeys, Y.; Pinart, Mariona; Basagaña Flores, Xavier; Smit, Henriëtte A.; Siroux, Valérie; Just, Jocelyne; Momas, Isabelle; Rancière, Fanny; Keil, Thomas; Hohmann, Cynthia; Lau, Susanne; Wahn, Ulrich; Heinrich, Joachim; Tischer, Christina; Fantini, Maria Pia; Lenzi, Jacopo; Porta, Daniela; Koppelman, Gerard H.; Postma, Dirkje S.; Berdel, Dietrich; Koletzko, Sibylle; Kerkhof, Marjan; Gehring, Ulrike; Wickman, Magnus; Melén, Erik; Hallberg, Jenny; Bindslev Jensen, Carsten; Eller, Esben; Kull, Inger; Lodrup Carlsen, Karin C.; Carlsen, Kai-Håkon; Lambrecht, Bart N.; Kogevinas, Manolis; Sunyer Deu, Jordi; Kauffmann, Francine; Bousquet, Jean; Antó i Boqué, Josep Maria (Wiley, 2015)
    BACKGROUND: Asthma, rhinitis and eczema often co-occur in children, but their interrelationships at the population level have been poorly addressed. We assessed co-occurrence of childhood asthma, rhinitis and eczema using ...
  • Prediction of peanut allergy in adolescence by early childhood storage protein-specific IgE signatures: The BAMSE population-based birth cohort
    Asarnoj, Anna; Hamsten, Carl; Lupinek, Christian; Melén, Erik; Andersson, Niklas; Antó i Boqué, Josep Maria; Bousquet, Jean; Valenta, Rudolf; van Hage, Marianne; Wickman, Magnus; Mechanisms of the Development of ALLergy (MeDALL) Consortium (Elsevier, 2017)
  • Prenatal particulate air pollution and DNA methylation in newborns: an epigenome-wide meta-analysis
    Gruzieva, Olena; Kogevinas, Manolis; Ruiz, José L.; Bustamante Pineda, Mariona; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; Vrijheid, Martine; Hernandez-Ferrer, Carles, 1987-; Melén, Erik (National Institute of Environmental Health Sciences (NIEHS), 2019)
    BACKGROUND: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes. OBJECTIVES: We aimed ...
  • Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study
    Siroux, Valérie; Lupinek, Christian; Resch, Yvonne; Curin, Mirela; Just, Jocelyne; Keil, Thomas; Kiss, Renata; Lodrup Carlsen, Karin C.; Melén, Erik; Nadif, Rachel; Pin, Isabelle; Skrindo, Ingebjorg; Vrtala, Susanne; Wickman, Magnus; Antó i Boqué, Josep Maria; Valenta, Rudolf; Bousquet, Jean (Elsevier, 2017)
    Background: The nature of allergens and route and dose of exposure may affect the natural development of IgE and IgG responses. Objective: We sought to investigate the natural IgE and IgG responses toward a large panel of ...
  • Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study
    Wang, Gang; Casas Sanahuja, Maribel; Abellan, Alicia; García Aymerich, Judith; Sunyer Deu, Jordi; Melén, Erik (European Respiratory Society, 2021)
    Background: The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these ...
  • The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL
    Keller, Theresa; Hohmann, Cynthia; Standl, Marie; Wijga, Alet; Gehring, Ulrike; Melén, Erik; Almqvist, Catarina; Lau, Susanne; Eller, Esben; Wahn, Ulrich; Christiansen, E.S.; von Berg, Andrea; Heinrich, Joachim; Lehmann, Irina; Maier, Dieter; Postma, Dirkje S.; Antó i Boqué, Josep Maria; Bousquet, Jean; Keil, Thomas; Roll, Stephanie (Wiley, 2018)
    Background - Cross‐sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex‐specific ...
  • Understanding allergic multimorbidity within the non-eosinophilic interactome
    Aguilar, Daniel; Lemonnier, Nathanael; Koppelman, Gerard H.; Melén, Erik; Oliva Miguel, Baldomero; Pinart, Mariona; Guerra, Stefano; Bousquet, Jean; Antó i Boqué, Josep Maria (Public Library of Science (PLoS), 2019)
    Background: The mechanisms explaining multimorbidity between asthma, dermatitis and rhinitis (allergic multimorbidity) are not well known. We investigated these mechanisms and their specificity in distinct cell types by ...

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