Browsing by Author "Melén, Erik"

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  • Melén, Erik; Antó i Boqué, Josep Maria; Gruzieva, Olena (Elsevier, 2021)
    Background: Whether long-term exposure air to pollution has effects on allergic sensitization is controversial. Objective: Our aim was to investigate associations of air pollution exposure at birth and at the time of later ...
  • Wickman, Magnus; Lupinek, Christian; Andersson, Niklas; Belgrave, Danielle; Asarnoj, Anna; Benet, Marta; Pinart, Mariona; Wieser, Sandra; García Aymerich, Judith; Baar, Alexandra; Pershagen, Göran; Simpson, Angela; Kull, Inger; Bergström, Anna; Melén, Erik; Hamsten, Carl; Antó i Boqué, Josep Maria; Bousquet, Jean; Custovic, Adnan; Valenta, Rudolf; van Hage, Marianne (Elsevier, 2017)
    BACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random ...
  • Vlaanderen, Jelle; de Hoogh, Kees; Hoek, Gerard; Peters, Annette; Probst-Hensch, Nicole; Scalbert, Augustin; Melén, Erik; Tonne, Cathryn; de Wit, G. Ardine; Chadeau-Hyam, Marc; Katsouyanni, Klea; Esko, Tõnu; Jongsma, Karin R.; Vermeulen, Roel (Wolters Kluwer (LWW), 2021)
    By 2030, more than 80% of Europe's population will live in an urban environment. The urban exposome, consisting of factors such as where we live and work, where and what we eat, our social network, and what chemical and ...
  • Merid, Simon Kebede; Kogevinas, Manolis; Bustamante Pineda, Mariona; Vrijheid, Martine; Sunyer Deu, Jordi; Antó i Boqué, Josep Maria; Melén, Erik (BioMed Central, 2020)
    Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ...
  • Gruzieva, Olena; Antó i Boqué, Josep Maria; Bustamante Pineda, Mariona; Guxens Junyent, Mònica; Sunyer Deu, Jordi; Melén, Erik (Environmental health perspectives, 2017)
    BACKGROUND: Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation. OBJECTIVES: We investigated associations ...
  • Merid, Simon Kebede; Bustamante Pineda, Mariona; Standl, Marie; Sunyer Deu, Jordi; Heinrich, Joachim; Lemonnier, Nathanael; Aguilar, Daniel; Antó i Boqué, Josep Maria; Bousquet, Jean; Santa Marina, Loreto; Lertxundi, Aitana; Bergström, Anna; Kull, Inger; Wheelock, Åsa M.; Koppelman, Gerard H.; Melén, Erik; Gruzieva, Olena (Elsevier, 2020)
    Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ...
  • Bousquet, Jean; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; Melén, Erik; Benet, Marta; Basagaña Flores, Xavier; Torrent Quetglas, Maties; Xu, Cheng-Jian (Wiley, 2016)
    MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for ...
  • García Aymerich, Judith; Benet, Marta; Saeys, Y.; Pinart, Mariona; Basagaña Flores, Xavier; Smit, Henriëtte A.; Siroux, Valérie; Just, Jocelyne; Momas, Isabelle; Rancière, Fanny; Keil, Thomas; Hohmann, Cynthia; Lau, Susanne; Wahn, Ulrich; Heinrich, Joachim; Tischer, Christina; Fantini, Maria Pia; Lenzi, Jacopo; Porta, Daniela; Koppelman, Gerard H.; Postma, Dirkje S.; Berdel, Dietrich; Koletzko, Sibylle; Kerkhof, Marjan; Gehring, Ulrike; Wickman, Magnus; Melén, Erik; Hallberg, Jenny; Bindslev Jensen, Carsten; Eller, Esben; Kull, Inger; Lodrup Carlsen, Karin C.; Carlsen, Kai-Håkon; Lambrecht, Bart N.; Kogevinas, Manolis; Sunyer Deu, Jordi; Kauffmann, Francine; Bousquet, Jean; Antó i Boqué, Josep Maria (Wiley, 2015)
    BACKGROUND: Asthma, rhinitis and eczema often co-occur in children, but their interrelationships at the population level have been poorly addressed. We assessed co-occurrence of childhood asthma, rhinitis and eczema using ...
  • Asarnoj, Anna; Hamsten, Carl; Lupinek, Christian; Melén, Erik; Andersson, Niklas; Antó i Boqué, Josep Maria; Bousquet, Jean; Valenta, Rudolf; van Hage, Marianne; Wickman, Magnus; Mechanisms of the Development of ALLergy (MeDALL) Consortium (Elsevier, 2017)
  • Gruzieva, Olena; Kogevinas, Manolis; Ruiz, José L.; Bustamante Pineda, Mariona; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; Vrijheid, Martine; Hernandez-Ferrer, Carles, 1987-; Melén, Erik (National Institute of Environmental Health Sciences (NIEHS), 2019)
    BACKGROUND: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes. OBJECTIVES: We aimed ...
  • Siroux, Valérie; Lupinek, Christian; Resch, Yvonne; Curin, Mirela; Just, Jocelyne; Keil, Thomas; Kiss, Renata; Lodrup Carlsen, Karin C.; Melén, Erik; Nadif, Rachel; Pin, Isabelle; Skrindo, Ingebjorg; Vrtala, Susanne; Wickman, Magnus; Antó i Boqué, Josep Maria; Valenta, Rudolf; Bousquet, Jean (Elsevier, 2017)
    Background: The nature of allergens and route and dose of exposure may affect the natural development of IgE and IgG responses. Objective: We sought to investigate the natural IgE and IgG responses toward a large panel of ...
  • Wang, Gang; Casas Sanahuja, Maribel; Abellan, Alicia; García Aymerich, Judith; Sunyer Deu, Jordi; Melén, Erik (UNLISTED PUBLISHER, 2021)
    Background: The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these ...
  • Keller, Theresa; Hohmann, Cynthia; Standl, Marie; Wijga, Alet; Gehring, Ulrike; Melén, Erik; Almqvist, Catarina; Lau, Susanne; Eller, Esben; Wahn, Ulrich; Christiansen, E.S.; von Berg, Andrea; Heinrich, Joachim; Lehmann, Irina; Maier, Dieter; Postma, Dirkje S.; Antó i Boqué, Josep Maria; Bousquet, Jean; Keil, Thomas; Roll, Stephanie (Wiley, 2018)
    Background - Cross‐sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex‐specific ...
  • Aguilar, Daniel; Lemonnier, Nathanael; Koppelman, Gerard H.; Melén, Erik; Oliva Miguel, Baldomero; Pinart, Mariona; Guerra, Stefano; Bousquet, Jean; Antó i Boqué, Josep Maria (Public Library of Science (PLoS), 2019)
    Background: The mechanisms explaining multimorbidity between asthma, dermatitis and rhinitis (allergic multimorbidity) are not well known. We investigated these mechanisms and their specificity in distinct cell types by ...