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Browsing by Author "Medina, Rebeca"

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Elucidation of the epitranscriptomic RNA modification landscape of Chikungunya Virus

Baquero Pérez, Belinda; Bortoletto, Enrico; Rosani, Umberto; Delgado-Tejedor, Anna; Medina, Rebeca; Novoa, Eva Maria; Venier, Paola; Díez Antón, Juana, 1962- (MDPI, 2024)

The genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus ...
High-performance nano-flow liquid chromatography column combined with high- and low-collision energy data-independent acquisition enables targeted and discovery identification of modified ribonucleotides by mass spectrometry

Espadas, Guadalupe; Morales Sanfrutos, Julia; Medina, Rebeca; Lucas, Morghan C.; Novoa, Eva Maria; Sabidó Aguadé, Eduard, 1981- (Elsevier, 2022)

Over 170 post-transcriptional RNA modifications have been described and are common in all kingdoms of life. These modifications range from methylation to complex chemical structures, with methylation being the most abundant. ...
N6-methyladenosine modification is not a general trait of viral RNA genomes

Baquero Pérez, Belinda; Yonchev, Ivaylo D.; Delgado-Tejedor, Anna; Medina, Rebeca; Puig-Torrents, Mireia; Sudbery, Ian; Begik, Oguzhan; Wilson, Stuart A.; Novoa, Eva Maria; Díez Antón, Juana, 1962- (Nature Research, 2024)

Despite the nuclear localization of the m6A machinery, the genomes of multiple exclusively-cytoplasmic RNA viruses, such as chikungunya (CHIKV) and dengue (DENV), are reported to be extensively m6A-modified. However, these ...
Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing

Lucas, Morghan C.; Pryszcz, Leszek Piotr, 1985-; Medina, Rebeca; Milenkovic, Ivan; Camacho, Noelia; Marchand, Virginie; Motorin, Yuri; Ribas de Pouplana, Lluís; Novoa, Eva Maria (Nature Research, 2024)

Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been difficult in part because a simple method to simultaneously quantify their abundance and chemical modifications is lacking. Here we ...
Quantitative profiling of pseudouridylation dynamics in native RNAs with nanopore sequencing

Begik, Oguzhan; Lucas, Morghan C.; Pryszcz, Leszek Piotr, 1985-; Ramirez, Jose Miguel; Medina, Rebeca; Milenkovic, Ivan; Cruciani, Sonia; Liu, Huanle; Santos Vieira, Helaine Graziele; Sas Chen, Aldema; Mattick, John S.; Schwartz, Schraga; Novoa, Eva Maria (Nature Research, 2021)

Nanopore RNA sequencing shows promise as a method for discriminating and identifying different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing to detect N6-methyladenosine, we show that ...

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Browsing by Author "Medina, Rebeca"

Browsing by Author "Medina, Rebeca"

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