Browsing by Author "Medel Lacruz, Brian"

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  • Torrens Fontanals, Mariona; Stepniewski, Tomasz Maciej, 1988-; Aranda García, David; Morales Pastor, Adrián; Medel Lacruz, Brian; Selent, Jana (MDPI, 2020)
    G protein-coupled receptors (GPCRs) are implicated in nearly every physiological process in the human body and therefore represent an important drug targeting class. Advances in X-ray crystallography and cryo-electron ...
  • Morales Pastor, Adrián; Nerín-Fonz, Francho; Aranda García, David; Dieguez-Eceolaza, Miguel; Medel Lacruz, Brian; Torrens Fontanals, Mariona; Peralta-Garcia, Alejandro; Selent, Jana (MDPI, 2002)
    Signaling bias is a promising characteristic of G protein-coupled receptors (GPCRs) as it provides the opportunity to develop more efficacious and safer drugs. This is because biased ligands can avoid the activation of ...
  • Kjaer, Viktoria Madeline Skovgaard; Stepniewski, Tomasz Maciej, 1988-; Medel Lacruz, Brian; Reinmuth, Lisa; Ciba, Marija; Rexen Ulven, Elisabeth; Bonomi, Massimiliano; Selent, Jana; Rosenkilde, Mette Marie (Royal Society of Chemistry, 2023)
    The G protein-coupled receptor GPR183 is a chemotactic receptor with an important function in the immune system and association with a variety of diseases. It recognizes ligands with diverse physicochemical properties as ...
  • Grimes, Jak; Koszegi, Zsombor; Lanoiselée, Yann; Miljus, Tamara; O'Brien, Shannon L.; Stepniewski, Tomasz Maciej, 1988-; Medel Lacruz, Brian; Baidya, Mithu; Makarova, Maria; Mistry, Ravi; Goulding, Joëlle; Drube, Julia; Hoffmann, Carsten; Owen, Dylan M.; Shukla, Arun K.; Selent, Jana; Hill, Stephen J.; Calebiro, Davide (Elsevier, 2023)
    β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the plasma membrane of ...

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