Browsing by Author "Mazzolini, Rocco"

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  • A proteomic analysis reveals that Snail regulates the expression of the nuclear orphan receptor Nuclear Receptor Subfamily 2 Group F Member 6 (Nr2f6) and interleukin 17 (IL-17) to inhibit adipocyte differentiation
    Peláez García, Alberto; Barderas, Rodrigo; Batlle Gómez, Raquel; Viñas Castells, Rosa, 1985-; Bartolome, Rubén A.; Torres, Sofía; Mendes, Marta; López Lucendo, María; Mazzolini, Rocco; Bonilla, Félix; García de Herreros, Antonio; Casal, José Ignacio (American Society for Biochemistry and Molecular Biology (ASBMB), 2015)
    Adipogenesis requires a differentiation program driven by multiple transcription factors, where PPARγ and C/EBPα play a central role. Recent findings indicate that Snail inhibits adipocyte differentiation in 3T3-L1 and ...
  • Analyzing the role of cancer-associated fibroblast activation on macrophage polarization
    Bruch Oms, Marina; Olivera-Salguero, Rubén, 1991-; Mazzolini, Rocco; Valle Pérez, Beatriz del; Mayo González, Paula; Beteta, Ángel; Peña Arranz, Raúl, 1976-; García de Herreros, Antonio (Wiley, 2023)
    Snail1 is a transcriptional factor required for cancer-associated fibroblast (CAF) activation, and mainly detected in CAFs in human tumors. In the mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) model ...
  • Characterization of different alginate lyases for dissolving Pseudomonas aeruginosa biofilms
    Blanco Cabra, Núria; Paetzold, Bernhard, 1981-; Ferrar, Tony; Mazzolini, Rocco; Torrents, Eduard; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (Nature Research, 2020)
    Aggregates of Pseudomonas aeruginosa form a protective barrier against antibiotics and the immune system. These barriers, known as biofilms, are associated with several infectious diseases. One of the main components of ...
  • Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms
    Mazzolini, Rocco; Rodríguez-Arce, Irene; Fernández-Barat, Laia; Piñero-Lambea, Carlos; Garrido, Victoria; Rebollada-Merino, Agustín; Motos, Ana; Torres, Antoni; Grilló, María-Jesús; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (Nature Research, 2023)
    Engineered live bacteria could provide a new modality for treating lung infections, a major cause of mortality worldwide. In the present study, we engineered a genome-reduced human lung bacterium, Mycoplasma pneumoniae, ...
  • Engineering Mycoplasma pneumoniae to bypass the association with Guillain-Barré syndrome
    Broto, Alicia; Piñero-Lambea, Carlos; Segura-Morales, Carolina; Tio-Gillen, Anne P.; Unger, Wendy W. J.; Burgos, Raul; Mazzolini, Rocco; Miravet Verde, Samuel, 1992-; Jacobs, Bart C.; Casas, Josefina; Huizinga, Ruth; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Elsevier, 2024)
    A non-pathogenic Mycoplasma pneumoniae-based chassis is leading the development of live biotherapeutic products (LBPs) for respiratory diseases. However, reports connecting Guillain-Barré syndrome (GBS) cases to prior M. ...
  • Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae
    Vizarraga, David; Mazzolini, Rocco; Lluch-Senar, Maria 1982-; Aparicio, David (Nature Research, 2020)
    Mycoplasma pneumoniae is a bacterial human pathogen that causes primary atypical pneumonia. M. pneumoniae motility and infectivity are mediated by the immunodominant proteins P1 and P40/P90, which form a transmembrane ...
  • ProTInSeq: transposon insertion tracking by ultra-deep DNA sequencing to identify translated large and small ORFs
    Miravet Verde, Samuel, 1992-; Mazzolini, Rocco; Segura-Morales, Carolina; Broto, Alicia; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Nature Research, 2024)
    Identifying open reading frames (ORFs) being translated is not a trivial task. ProTInSeq is a technique designed to characterize proteomes by sequencing transposon insertions engineered to express a selection marker when ...
  • Snail1 expression is required for sarcomagenesis
    Alba-Castellón, Lorena; Batlle, Raquel; Francí, Clara; Fernández Aceñero, María Jesús; Mazzolini, Rocco; Peña, Raúl; Loubat, Jordina; Alameda Quitllet, Francisco; Rodríguez, Rufo; Curto, Josué; Albanell, Joan; Muñoz, Alberto; Bonilla, Félix; Casal, José Ignacio; Rojo, Federico; García de Herreros, Antonio (Elsevier, 2014)
    Snail1 transcriptional repressor is a major inducer of epithelial-to mesenchymal transition but is very limitedly expressed in adult animals. We have previously demonstrated that Snail1 is required for the maintenance of ...
  • Snail1 transcription factor controls telomere transcription and integrity
    Mazzolini, Rocco; Gonzàlez Busqué, Núria, 1980-; Garcia-Garijo, Andrea; Millanes Romero, Alba, 1986-; Peiró Sales, Sandra; Smith, Susan; García de Herreros, Antonio; Canudas i Puig, Sílvia (Oxford University Press, 2018)
    Besides controlling epithelial-to-mesenchymal transition (EMT) and cell invasion, the Snail1 transcriptional factor also provides cells with cancer stem cell features. Since telomere maintenance is essential for stemness, ...
  • Splicing of a non-coding antisense transcript controls LEF1 gene expression.
    Beltran, Manuel; Aparicio i Prat, Estel, 1986-; Mazzolini, Rocco; Millanes Romero, Alba, 1986-; Massó, Pere; Jenner, Richard G.; Díaz, Víctor M.; Peiró Sales, Sandra; García de Herreros, Antonio (Oxford University Press, 2015)
    In this report we have analyzed the role of antisense transcription in the control of LEF1 transcription factor expression. A natural antisense transcript (NAT) is transcribed from a promoter present in the first intron ...
  • Unraveling the hidden universe of small proteins in bacterial genomes
    Miravet Verde, Samuel, 1992-; Ferrar, Tony; Espadas, Guadalupe; Mazzolini, Rocco; Gharrab, Anas; Sabidó Aguadé, Eduard, 1981-; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (Wiley Open Access, 2019)
    Identification of small open reading frames (smORFs) encoding small proteins (≤ 100 amino acids; SEPs) is a challenge in the fields of genome annotation and protein discovery. Here, by combining a novel bioinformatics tool ...

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