Browsing by Author "Mayor, Alfredo"

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  • A targeted association study of immunity genes and networks suggests novel associations with placental malaria infection
    Sikora, Martin, 1976-; Laayouni, Hafid, 1968-; Menéndez, Clara; Mayor, Alfredo; Bardaji, Azucena; Sigauque, Betuel; Netea, Mihai G; Casals López, Ferran; Bertranpetit, Jaume, 1952- (Public Library of Science (PLoS), 2011)
    A large proportion of the death toll associated with malaria is a consequence of malaria infection during pregnancy, causing up to 200,000 infant deaths annually. We previously published the first extensive genetic association ...
  • A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
    Sikora, Martin, 1976-; Ferrer Admetlla, Anna; Laayouni, Hafid, 1968-; Menéndez, Clara; Mayor, Alfredo; Bardaji, Azucena; Sigauque, Betuel; Mandomando, Inacio; Alonso, Pedro L.; Bertranpetit, Jaume, 1952-; Casals López, Ferran (Oxford University Press, 2009)
    Malaria in pregnancy forms a substantial part of the worldwide burden of malaria, with an estimated annual death toll of up to 200,000 infants, as well as increased maternal morbidity and mortality. Studies of genetic ...
  • Circulating miRNAs, isomiRs and small RNA clusters in human plasma and breast milk
    Rubio Martínez, Mercedes, 1980-; Bustamante Pineda, Mariona; Hernandez-Ferrer, Carles, 1987-; Fernández-Orth, Dietmar; Pantano Rubiño, Lorena, 1982-; Sarria-Trujillo, Yaris; Piqué-Borras, Maria; Vellve del Amo, Kilian; Agramunt, Silvia; Carreras Collado, Ramón; Estivill, Xavier, 1955-; González Ruiz, Juan Ramón; Mayor, Alfredo (Public Library of Science (PLoS), 2018)
    Circulating small RNAs, including miRNAs but also isomiRs and other RNA species, have the potential to be used as non-invasive biomarkers for communicable and non-communicable diseases. This study aims to characterize and ...
  • Determinants of early antibody responses to COVID-19 mRNA vaccines in a cohort of exposed and naïve healthcare workers
    Moncunill, Gemma; Aguilar, Ruth; Ribes, Marta; Ortega, Natalia; Rubio, Rocío; Molina, María José; Vidal, Marta; Barrios, Diana; Mitchell, Robert A.; Jiménez, Alfons; Castellana, Cristina; Rodó, Pau; Méndez, Susana; Llupià, Anna; Puyol, Laura; Rodrigo Melero, Natalia; Carolis, Carlo; Mayor, Alfredo; Izquierdo, Luis; Trilla, Antoni; Vilella, Anna; García-Basteiro, Alberto L.; Dobaño, Carlota (Elsevier, 2022)
    Background: Two doses of mRNA vaccination have shown >94% efficacy at preventing COVID-19 mostly in naïve adults, but it is not clear if the second dose is needed to maximize effectiveness in those previously exposed to ...
  • Evolutionary analysis of genes of two pathways involved in placental malaria infection
    Sikora, Martin, 1976-; Ferrer Admetlla, Anna; Mayor, Alfredo; Bertranpetit, Jaume, 1952-; Casals López, Ferran (Springer, 2008)
    Placental malaria is a special form of malaria that causes up to 200,000 maternal and infant deaths every year. Previous studies show that two receptor molecules, hyaluronic acid and chondroitin sulphate A, are mediating ...
  • Plasma MicroRNA profiling of Plasmodium falciparum biomass and association with severity of malaria disease
    Gupta, Himanshu; Rubio, Mercedes; Sitoe, Antonio; Varo, Rosauro; Cisteró, Pau; Madrid, Lola; Cuamba, Inocencia; Jiménez, Alfons; Martiáñez-Vendrell, Xavier; Barrios, Diana; Pantano Rubiño, Lorena, 1982-; Brimacombe, Allison; Bustamante Pineda, Mariona; Bassat, Quique; Mayor, Alfredo (Centers for Disease Control and Prevention, 2021)
    Severe malaria (SM) is a major public health problem in malaria-endemic countries. Sequestration of Plasmodium falciparum-infected erythrocytes in vital organs and the associated inflammation leads to organ dysfunction. ...
  • RBD-Based ELISA and luminex predict Anti-SARS-CoV-2 surrogate-neutralizing activity in two longitudinal cohorts of German and Spanish health care workers
    Aguilar, Ruth; Vidal, Marta; Rubio, Rocío; Jiménez, Alfons; Carolis, Carlo; Mayor, Alfredo; Izquierdo, Luis; Garcia Basteiro, Alberto L.; Moncunill, Gemma; Dobaño, Carlota; Gerhard, Markus (American Society for Microbiology, 2023)
    The ability of antibodies to neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important correlate of protection. For routine evaluation of protection, however, a simple and cost-efficient ...
  • Seven-month kinetics of SARS-CoV-2 antibodies and role of pre-existing antibodies to human coronaviruses
    Ortega, Natalia; Ribes, Marta; Vidal, Marta; Rubio, Rocío; Aguilar, Ruth; Williams, Sarah; Barrios, Diana; Alonso, Selena; Mitchell, Robert A.; Jairoce, Chenjerai; Cruz, Angeline; Jimenez, Alfons; Santano, Rebeca; Méndez, Susana; Lamoglia, Montserrat; Rosell, Neus; Llupià, Anna; Puyol, Laura; Chi, Jordi; Rodrigo Melero, Natalia; Mayor, Alfredo; Vilella, Anna; Trilla, Antoni; Carolis, Carlo; Izquierdo, Luis; García-Basteiro, Alberto L.; Moncunill, Gemma; Dobaño, Carlota (Nature Research, 2021)
    Unraveling the long-term kinetics of antibodies to SARS-CoV-2 and the individual characteristics influencing it, including the impact of pre-existing antibodies to human coronaviruses causing common cold (HCoVs), is essential ...
  • Tying malaria and microRNAs: from the biology to future diagnostic perspectives
    Rubio, Mercedes; Bassat, Quique; Estivill, Xavier, 1955-; Mayor, Alfredo (BioMed Central, 2016)
    Symptoms caused by bacterial, viral and malarial infections usually overlap and aetiologic diagnosis is difficult. Patient management in low-resource countries with limited laboratory services has been based predominantly ...