Browsing by Author "Martinez, Javier P."

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  • Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1
    Martinez, Javier P.; Bocharov, Gennady A.; Ignatovich, Anna; Reiter, Jochen; Dittmar, Matthias T; Wain-Hobson, Simon; Meyerhans, Andreas (Public Library of Science (PLoS), 2011)
    Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness ...
  • Identification of myxobacteria-derived HIV inhibitors by a high-throughput two-step infectivity assay
    Martinez, Javier P.; Hinkelmann, Bettina; Fleta Soriano, Eric, 1983-; Steinmetz, Heinrich; Jansen, Rolf; Díez Antón, Juana, 1962-; Frank, Ronald; Sasse, Florenz; Meyerhans, Andreas (BioMed Central, 2013)
    Drug-resistance and therapy failure due to drug-drug interactions are the main challenges in current treatment against Human Immunodeficiency Virus (HIV) infection. As such, there is a continuous need for the development ...
  • Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1
    Herrmann, Madeleine; Ruprecht, Klemens; Sauter, Marlies; Martinez, Javier P.; van Heteren, Pearl; Glas, Michael; Best, Barbara; Meyerhans, Andreas; Roemer, Klaus; Mueller-Lantzsch, Nikolaus (Elsevier, 2010)
    Retrovirus replication critically depends on a dynamic interplay between retroviral and host proteins. We report on the binding of the surface subunit (glycoprotein 120 (gp120)) of the human immunodeficiency virus type 1 ...
  • Mathematical modelling of the within-host HIV quasispecies dynamics in response to antiviral treatment
    Bocharov, Gennady A.; Telatnikov, Ilya S.; Chereshnev, Valery A.; Martinez, Javier P.; Meyerhans, Andreas (De Gruyter, 2015)
    The aim of this work is the construction, calibration, and comparative analysis of mathematical models of the evolution of the human immunodeficiency virus (HIV) in the course of infection when the models are based on ...
  • The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway
    Fleta Soriano, Eric, 1983-; Martinez, Javier P.; Hinkelmann, Bettina; Gerth, Klaus; Washausen, Peter; Díez Antón, Juana, 1962-; Frank, Ronald; Sasse, Florenz; Meyerhans, Andreas (BioMed Central, 2014)
    Background: The nuclear export of unspliced and partially spliced HIV-1 mRNA is mediated by the recognition of a leucine-rich nuclear export signal (NES) in the HIV Rev protein by the host protein CRM1/Exportin1. This makes ...
  • Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity
    Martinez, Javier P.; Lisa, Silvia; Sánchez, Rosa; Kowalczyk, Wioleta; Zurita, Esther; Teixidó, Meritxell; Giralt, Ernest; Andreu Martínez, David; Avila, Jesús; Gasset, María (Public Library of Science (PLoS), 2011)
    Background: The capacity of a polypeptide chain to engage in an amyloid formation process and cause a conformational disease is contained in its sequence. Some of the sequences undergoing fibrillation contain critical ...
  • The myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion composition
    Fleta Soriano, Eric, 1983-; Smutná, Katarína, 1991-; Martinez, Javier P.; Lorca Oró, Cristina; Sadiq, S. Kashif; Mirambeau, Gilles; Lopez-Iglesias, Carmen; Bosch, Marta; Pol, Albert; Brönstrup, Mark; Díez Antón, Juana, 1962-; Meyerhans, Andreas (American Society for Microbiology, 2017)
    Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production ...